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    Methods for identifying agents that modulate LGIC receptor activity
    1.
    发明授权
    Methods for identifying agents that modulate LGIC receptor activity 有权
    鉴定调节LGIC受体活性的试剂的方法

    公开(公告)号：US07947466B2

    公开(公告)日：2011-05-24

    申请号：US10938370

    申请日：2004-09-11

    申请人： Scott B. Hansen ,  Palmer Taylor ,  Zoran Radic

    发明人： Scott B. Hansen ,  Palmer Taylor ,  Zoran Radic

    IPC分类号： G01N33/483 ,  G01N33/52

    CPC分类号： G01N33/542 ,  A61K38/17 ,  C07K14/43504 ,  G01N33/944 ,  G01N2500/04

    摘要： Fluorescence based screening assays are provided that allow for the for identification of agents that selectively bind to a ligand-gated ion channel (LGIC) such as a nicotinic acetylcholine receptor (nAChR). Also provided are methods for identifying agents that selectively bind to a neuronal-type nAChR by detecting binding of the agent to an Aplysia AChBP, which is representative of a neuronal-type nAChR. In addition, compositions and kits for performing such methods are provided.

    摘要翻译： 提供基于荧光的筛选测定法，其允许鉴定选择性结合配体门控离子通道（LGIC）如烟碱乙酰胆碱受体（nAChR）的试剂。 还提供了通过检测代谢神经元型nAChR的Aplysia AChBP的结合来鉴定选择性结合神经元型nAChR的试剂的方法。 此外，提供了用于执行这些方法的组合物和试剂盒。

    Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity
    4.
    发明申请
    Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity 有权
    配体感测荧光乙酰胆碱酯酶用于检测有机磷酸酯活性

    公开(公告)号：US20050089926A1

    公开(公告)日：2005-04-28

    申请号：US10469731

    申请日：2003-04-16

    申请人： Palmer Taylor ,  Zoran Radie ,  Jian Shi ,  Aileen Boyd

    发明人： Palmer Taylor ,  Zoran Radie ,  Jian Shi ,  Aileen Boyd

    IPC分类号： C12N9/18 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543

    CPC分类号： C12N9/18

    摘要： Disclosed are methods for the preparation and use of labeled AChE and labeled AChE inhibitory conjugate compositions for detecting accumulation of toxic materials such as organophosphates, insecticides, and other nerve agents. Also disclosed are methods for the use of labeled AChE and labeled AChE inhibitory conjugate compositions in a variety of areas, including the detecting of toxic materials in biological samples, in the area of food and water analysis, in environmental monitoring, and in industrial settings.

    摘要翻译： 公开了用于制备和使用标记的AChE和标记的AChE抑制性缀合物组合物的方法，用于检测有毒物质如有机磷酸盐，杀虫剂和其它神经毒剂的积累。 还公开了在各种领域中使用标记的AChE和标记的AChE抑制性缀合物组合物的方法，包括在食品和水分析领域，环境监测和工业环境中检测生物样品中的有毒物质。

    Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity
    5.
    发明授权
    Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity 有权
    配体感测荧光乙酰胆碱酯酶用于检测有机磷酸酯活性

    公开(公告)号：US08642273B2

    公开(公告)日：2014-02-04

    申请号：US10469731

    申请日：2003-04-16

    申请人： Palmer Taylor ,  Zoran Radic ,  Jianxin Shi ,  Aileen Boyd

    发明人： Palmer Taylor ,  Zoran Radic ,  Jianxin Shi ,  Aileen Boyd

    IPC分类号： C12N9/18

    CPC分类号： C12N9/18

    摘要： Disclosed are methods for the preparation and use of labeled AChE and labeled AChE inhibitory conjugate compositions for detecting accumulation of toxic materials such as organophosphates, insecticides, and other nerve agents. Also disclosed are methods for the use of labeled AChE and labeled AChE inhibitory conjugate compositions in a variety of areas, including the detecting of toxic materials in biological samples, in the area of food and water analysis, in environmental monitoring, and in industrial settings.

    摘要翻译： 公开了用于制备和使用标记的AChE和标记的AChE抑制性缀合物组合物的方法，用于检测有毒物质如有机磷酸盐，杀虫剂和其它神经毒剂的积累。 还公开了在各种领域中使用标记的AChE和标记的AChE抑制性缀合物组合物的方法，包括在食品和水分析领域，环境监测和工业环境中检测生物样品中的有毒物质。