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    SYSTEM AND METHOD FOR TREATING TUMORS
    1.
    发明申请
    SYSTEM AND METHOD FOR TREATING TUMORS 审中-公开
    用于治疗肿瘤的系统和方法

    公开(公告)号：US20100240995A1

    公开(公告)日：2010-09-23

    申请号：US12726037

    申请日：2010-03-17

    申请人： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin Tran ,  Brian Athos ,  Mark Kreis

    发明人： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin Tran ,  Brian Athos ,  Mark Kreis

    IPC分类号： A61B18/14 ,  A61B8/00

    CPC分类号： A61B18/1492 ,  A61B8/12 ,  A61B18/1477 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2090/3782

    摘要： Systems and methods for treating tumors on or within internal organs of mammals that have been imaged with endoscopic ultrasound are described. The system uses an expandable bipolar electrode assembly that can be imaged by ultrasound and can penetrate, e.g., the stomach, intestine or bowel wall, etc. and be positioned in or around the tumor on an internal organ while being guided by an operator who visualizes its position with ultrasound imaging. It utilizes an electrode assembly that extends down an internal cavity in the endoscope to allow the operator to spread the electrodes for pulse delivery of a nanosecond pulsed electric field (nsPEF) to the tumor.

    摘要翻译： 描述了已经用内窥镜超声成像的用于治疗哺乳动物的内部器官上或内部的肿瘤的系统和方法。 该系统使用可通过超声波成像的可扩张双极电极组件，并且可以穿透例如胃，肠或肠壁等，并且定位在内部器官的肿瘤内或周围，同时由可视化的操作者引导 其位置与超声成像。 它利用沿内窥镜内腔延伸的电极组件，以允许操作者将电极扩展到纳秒脉冲电场（nsPEF）的脉冲输送到肿瘤。

    Suction electrode-based medical instrument and system including the medical instrument for therapeutic electrotherapy
    3.
    发明授权
    Suction electrode-based medical instrument and system including the medical instrument for therapeutic electrotherapy 有权
    基于吸收电极的医疗器械和系统，包括用于治疗电疗的医疗器械

    公开(公告)号：US08688227B2

    公开(公告)日：2014-04-01

    申请号：US12599259

    申请日：2008-05-09

    申请人： Richard L. Nuccitelli ,  Uwe F. Pliquett ,  Pamela Nuccitelli ,  Changyi Li ,  Saleh H. Sheikh

    发明人： Richard L. Nuccitelli ,  Uwe F. Pliquett ,  Pamela Nuccitelli ,  Changyi Li ,  Saleh H. Sheikh

    IPC分类号： A61B18/14

    CPC分类号： A61N1/0452 ,  A61N1/0412 ,  A61N1/0456 ,  A61N1/0472 ,  A61N1/32

    摘要： A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.

    摘要翻译： 提供了一种用于提供电疗的医疗仪器。 仪器包括外部支撑构件，该外部支撑构件具有敞开的远端，并且支撑构件内的底壁部分布置成在远端处形成杯状体积。 仪器还包括形成在杯状体积中的至少一个孔，用于向杯状区域施加抽吸。 所述仪器还包括第一和第二电极，所述第一和第二电极具有在所述杯状区域内或靠近所述杯状区域的至少一部分，以在偏置信号施加在所述第一和第二电极之间时在所述杯状区域中提供电场。

    HAND-HELD ELECTRIC FIELD IMAGER FOR MEASURING THE SURFACE TOPOGRAPHY OF MAMMALIAN SKIN AND OTHER EPITHELIAL STRUCTURES
    5.
    发明申请
    HAND-HELD ELECTRIC FIELD IMAGER FOR MEASURING THE SURFACE TOPOGRAPHY OF MAMMALIAN SKIN AND OTHER EPITHELIAL STRUCTURES 有权
    手持式电场成像仪，用于测量MAMMALIAN皮肤和其他上皮结构的表面形貌

    公开(公告)号：US20100016686A1

    公开(公告)日：2010-01-21

    申请号：US12484971

    申请日：2009-06-15

    申请人： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Suman NARSING ,  Brian ATHOS ,  Saleh SHEIKH

    发明人： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Suman NARSING ,  Brian ATHOS ,  Saleh SHEIKH

    IPC分类号： A61B5/04

    CPC分类号： A61B5/442 ,  A61B5/0051 ,  A61B5/053 ,  A61B5/063 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6886

    摘要： The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

    摘要翻译： 本发明提供了用于测量哺乳动物皮肤和其它上皮结构中的电场的手持式无创诊断装置。 该装置包括接触皮肤的外壳，提供稳定性并允许装置随着皮肤的轻微移动而移动。 嵌入在外壳内部的探头是用作传感器的探针，用于通过外壳底面的孔来测量皮肤中的电场。 通过在探头振动时应用一系列已知的电压，可以测量皮肤的局部表面电位，并可以从表面电位测量的空间分布计算横向电场。 主动反馈用于保持探头与皮肤表面之间的恒定距离。

    Hand-held electric field imager for measuring the surface topography of mammalian skin and other epithelial structures
    7.
    发明授权
    Hand-held electric field imager for measuring the surface topography of mammalian skin and other epithelial structures 有权
    用于测量哺乳动物皮肤和其他上皮结构的表面形貌的手持电场成像仪

    公开(公告)号：US08597187B2

    公开(公告)日：2013-12-03

    申请号：US12484971

    申请日：2009-06-15

    申请人： Richard Lee Nuccitelli ,  Pamela Nuccitelli ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

    发明人： Richard Lee Nuccitelli ,  Pamela Nuccitelli ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

    IPC分类号： A61B5/103

    CPC分类号： A61B5/442 ,  A61B5/0051 ,  A61B5/053 ,  A61B5/063 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6886

    摘要： The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

    摘要翻译： 本发明提供了用于测量哺乳动物皮肤和其它上皮结构中的电场的手持式无创诊断装置。 该装置包括接触皮肤的外壳，提供稳定性并允许装置随着皮肤的轻微移动而移动。 嵌入在外壳内部的探头是用作传感器的探针，用于通过外壳底面的孔来测量皮肤中的电场。 通过在探头振动时应用一系列已知的电压，可以测量皮肤的局部表面电位，并可以从表面电位测量的空间分布计算横向电场。 主动反馈用于保持探头与皮肤表面之间的恒定距离。

    SUCTION ELECTRODE-BASED MEDICAL INSTRUMENT AND SYSTEM INCLUDING THE MEDICAL INSTRUMENT FOR THERAPEUTIC ELECTROTHERAPY
    9.
    发明申请
    SUCTION ELECTRODE-BASED MEDICAL INSTRUMENT AND SYSTEM INCLUDING THE MEDICAL INSTRUMENT FOR THERAPEUTIC ELECTROTHERAPY 有权
    基于电极的医用仪器和系统，包括用于治疗电磁疗的医疗仪器

    公开(公告)号：US20110009929A1

    公开(公告)日：2011-01-13

    申请号：US12599259

    申请日：2008-05-09

    申请人： Richard L. Nuccitelli ,  Uwe F. Pliquett ,  Pamela Nuccitelli ,  Changyi Li ,  Saleh H. Sheikh

    发明人： Richard L. Nuccitelli ,  Uwe F. Pliquett ,  Pamela Nuccitelli ,  Changyi Li ,  Saleh H. Sheikh

    IPC分类号： A61N1/04

    CPC分类号： A61N1/0452 ,  A61N1/0412 ,  A61N1/0456 ,  A61N1/0472 ,  A61N1/32

    摘要： A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.

    摘要翻译： 提供了一种用于提供电疗的医疗仪器。 仪器包括外部支撑构件，该外部支撑构件具有敞开的远端，并且支撑构件内的底壁部分布置成在远端处形成杯状体积。 仪器还包括形成在杯状体积中的至少一个孔，用于向杯状区域施加抽吸。 所述仪器还包括第一和第二电极，所述第一和第二电极具有在所述杯状区域内或靠近所述杯状区域的至少一部分，以在偏置信号施加在所述第一和第二电极之间时在所述杯状区域中提供电场。