公开(公告)号：US20050209443A1

公开(公告)日：2005-09-22

申请号：US11113441

申请日：2005-04-22

申请人： Paul Bolen ,  Paul Cihak ,  Lewis Scharpf ,  Kevin Miller ,  Nicolas Kossiakoff ,  Regina Hawn

发明人： Paul Bolen ,  Paul Cihak ,  Lewis Scharpf ,  Kevin Miller ,  Nicolas Kossiakoff ,  Regina Hawn

IPC分类号： C07K14/43 ,  C07K16/16 ,  C07K16/20 ,  C07K16/40

CPC分类号： C07K16/16 ,  C07K14/43 ,  C07K16/20 ,  C07K16/40

摘要： A modified thaumatin protein, a modified monellin protein and antibodies thereto are provided. Further, nucleic acid sequences and vectors capable of expressing thaumatin or monellin are provided.

摘要翻译： 本发明提供了修饰的甜蛋白蛋白，修饰的monellin蛋白及其抗体。 此外，提供能够表达甜蛋白或蒙乃宁的核酸序列和载体。

公开(公告)号：US20050096662A1

公开(公告)日：2005-05-05

申请号：US10698638

申请日：2003-10-31

申请人： Rex Shores ,  Paul Cihak ,  Larry Estes

发明人： Rex Shores ,  Paul Cihak ,  Larry Estes

IPC分类号： A61B17/00 ,  A61B17/16 ,  A61B17/32 ,  A61B17/14

CPC分类号： A61B17/32002 ,  A61B17/162 ,  A61B17/1633 ,  A61B2017/00477

摘要： The present invention provides improved coupling arrangements for medical instruments. In one example, a coupling system for a medical dissection tool includes: an internal passage adapted for receiving a portion of a medical dissection tool; and at least one locking member movable through a first angled path into a locked position to prevent the medical dissection tool from moving along a longitudinal axis of the internal passage.

摘要翻译： 本发明提供了用于医疗器械的改进的联接装置。 在一个示例中，用于医疗解剖工具的联接系统包括：适于接收医疗解剖工具的一部分的内部通道; 以及至少一个锁定构件，其可通过第一成角度的路径移动到锁定位置，以防止医学解剖工具沿着内部通道的纵向轴线移动。

公开(公告)号：US08936597B2

公开(公告)日：2015-01-20

申请号：US13366957

申请日：2012-02-06

申请人： John Xinghai Wang ,  Hung Van Bach ,  Donna J. Burnette ,  Walter Raymond Blackwell ,  Weiguo Chen ,  S. Shane Dexter ,  Vikram August Garadi ,  Kevin L. Haney ,  Joseph William Lopez ,  R. Mitchell Sherry ,  Paul Cihak ,  Durrell Tidwell

发明人： John Xinghai Wang ,  Hung Van Bach ,  Donna J. Burnette ,  Walter Raymond Blackwell ,  Weiguo Chen ,  S. Shane Dexter ,  Vikram August Garadi ,  Kevin L. Haney ,  Joseph William Lopez ,  R. Mitchell Sherry ,  Paul Cihak ,  Durrell Tidwell

IPC分类号： A61B17/00

CPC分类号： A61B17/142 ,  A61B17/14 ,  A61B2017/0046 ,  A61B2017/00526 ,  B23D61/006 ,  B27B5/32 ,  Y10T29/49876

摘要： A surgical cutting blade for cutting bone material when the blade is coupled to a hand-held surgical saw includes a distal portion comprising a plurality of cutting teeth, a shank portion adjacent the distal portion, and a proximal portion adjacent the shank portion. The proximal portion may include a longitudinally extending slot having a proximal opening. The slot may be shaped to receive a portion of the surgical saw through the proximal opening. The proximal portion may have a plurality of deflectable fingers respectively separated from a plurality of main body portions by respective gaps. The plurality of deflectable fingers may extend adjacent the longitudinally extending slot, and may deflect into the gaps to increase and decrease a width of a portion of the slot.

摘要翻译： 一种用于当刀片联接到手持式手术锯上时切割骨材料的手术切割刀片包括：远端部分，其包括多个切割齿，与所述远端部分相邻的柄部分，以及邻近所述柄部分的近侧部分。 近端部分可以包括具有近端开口的纵向延伸的狭槽。 狭槽可以被成形为通过近端开口接收外科手术锯的一部分。 近端部分可以具有分别通过相应的间隙与多个主体部分分离的多个可偏转的手指。 多个可偏转指状物可以在纵向延伸的狭槽附近延伸，并且可以偏转到间隙中以增加和减小狭槽的一部分的宽度。

公开(公告)号：US20130204256A1

公开(公告)日：2013-08-08

申请号：US13366957

申请日：2012-02-06

申请人： John Xinghai Wang ,  Hung Van Bach ,  Donna J. Burnette ,  Walter Raymond Blackwell ,  Weiguo Chen ,  S. Shane Dexter ,  Vikram August Garadi ,  Kevin L. Haney ,  Joseph William Lopez ,  R. Mitchell Sherry ,  Paul Cihak ,  Durrell Tidwell

发明人： John Xinghai Wang ,  Hung Van Bach ,  Donna J. Burnette ,  Walter Raymond Blackwell ,  Weiguo Chen ,  S. Shane Dexter ,  Vikram August Garadi ,  Kevin L. Haney ,  Joseph William Lopez ,  R. Mitchell Sherry ,  Paul Cihak ,  Durrell Tidwell

IPC分类号： A61B17/14

CPC分类号： A61B17/142 ,  A61B17/14 ,  A61B2017/0046 ,  A61B2017/00526 ,  B23D61/006 ,  B27B5/32 ,  Y10T29/49876

摘要： A surgical cutting blade for cutting bone material when the blade is coupled to a hand-held surgical saw includes a distal portion comprising a plurality of cutting teeth, a shank portion adjacent the distal portion, and a proximal portion adjacent the shank portion. The proximal portion may include a longitudinally extending slot having a proximal opening. The slot may be shaped to receive a portion of the surgical saw through the proximal opening. The proximal portion may have a plurality of deflectable fingers respectively separated from a plurality of main body portions by respective gaps. The plurality of deflectable fingers may extend adjacent the longitudinally extending slot, and may deflect into the gaps to increase and decrease a width of a portion of the slot.

摘要翻译： 一种用于当刀片联接到手持式手术锯上时切割骨材料的手术切割刀片包括：远端部分，其包括多个切割齿，与所述远端部分相邻的柄部分，以及邻近所述柄部分的近侧部分。 近端部分可以包括具有近端开口的纵向延伸的狭槽。 狭槽可以被成形为通过近端开口接收外科手术锯的一部分。 近端部分可以具有分别通过相应的间隙与多个主体部分分离的多个可偏转的手指。 多个可偏转指状物可以在纵向延伸的狭槽附近延伸，并且可以偏转到间隙中以增加和减小狭槽的一部分的宽度。

公开(公告)号：US20060178672A1

公开(公告)日：2006-08-10

申请号：US10698177

申请日：2003-10-31

申请人： Rex Shores ,  Larry Estes ,  Paul Cihak ,  Allen Hilton ,  Donald Hilton

发明人： Rex Shores ,  Larry Estes ,  Paul Cihak ,  Allen Hilton ,  Donald Hilton

IPC分类号： A61B17/16

CPC分类号： A61B17/1633 ,  A61B17/32002 ,  A61B2017/0046 ,  A61B2017/320032

摘要： In one embodiment, there is disclosed a surgical instrument for the dissection of bone or other tissue, the surgical instrument including a tool having a shaft with a dissection area disposed adjacent a distal end and a coupling area disposed adjacent a proximal end; a coupling assembly configured for coupling to a power output of a motor to said coupling area of said tool; and an angled attachment tube positionable along at least a portion of said shaft and substantially supporting a portion of said shaft disposed adjacent said dissection area.

公开(公告)号：US20050106698A1

公开(公告)日：2005-05-19

申请号：US10870399

申请日：2004-06-17

申请人： Paul Bolen ,  Paul Cihak ,  Lewis Scharpf

发明人： Paul Bolen ,  Paul Cihak ,  Lewis Scharpf

IPC分类号： A23C19/04 ,  A61K38/00 ,  C12N9/20 ,  C12N9/16 ,  C07H21/04 ,  C12N1/18 ,  C12N1/21 ,  C12N15/74

CPC分类号： C12N9/20 ,  A23C19/043 ,  A61K38/00

摘要： The present invention provides kPGE and derivative polypeptides which are capable of being produced by genetic recombination and used to produce EMCs. This invention further provides nucleic acid sequences encoding kPGE and derivative polypeptides which can be used to create recombinant host cells that express kPGE and derivative polypeptides. A further subject of the present of invention is a fusion polypeptide called polyHis-enterokinase which increases expression of esterases and lipases when fused to the N-terminal of the esterase or lipase. This invention also provides a method for treating animals with an esterase or lipase deficiency by administering rkPGE to the animal in a therapeutically effective amount.

公开(公告)号：US20060041268A1

公开(公告)日：2006-02-23

申请号：US10919745

申请日：2004-08-17

申请人： Rex Shores ,  Paul Cihak ,  Allen Hilton

发明人： Rex Shores ,  Paul Cihak ,  Allen Hilton

IPC分类号： A61B17/32

CPC分类号： A61B17/1633 ,  A61B17/32 ,  A61B17/320016 ,  A61B2017/00473 ,  A61B2017/00477 ,  A61B2017/320032 ,  A61C1/10

摘要： A surgical attachment instrument and method according to which a housing is adapted to be coupled to a motor. A tubular member is coupled to the housing so that an end of the tubular member extends from the housing at a predetermined distance. The predetermined distance may be selectively adjusted by a repeatable increment.

摘要翻译： 一种外科附件仪器和方法，根据该方法，壳体适于联接到电动机。 管状构件联接到壳体，使得管状构件的端部以预定距离从壳体延伸。 可以通过可重复的增量选择性地调整预定距离。