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公开(公告)号：US06680168B2
公开(公告)日：2004-01-20
申请号：US09815452
申请日：2001-03-22
IPC分类号： C12Q100
CPC分类号： A61K39/08 , A61K39/00 , A61K2039/505 , A61K2039/54 , C07K14/33 , C07K16/1282
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：US09226956B2
公开(公告)日：2016-01-05
申请号：US13457821
申请日：2012-04-27
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：US06214341B1
公开(公告)日：2001-04-10
申请号：US09176076
申请日：1998-10-20
IPC分类号： A61K39395
CPC分类号： A61K39/08 , A61K39/00 , A61K2039/505 , A61K2039/54 , C07K14/33 , C07K16/1282
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：US06969520B2
公开(公告)日：2005-11-29
申请号：US10737270
申请日：2003-12-16
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：US20130177592A1
公开(公告)日：2013-07-11
申请号：US13457821
申请日：2012-04-27
IPC分类号： A61K39/08
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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