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公开(公告)号：US20130177592A1
公开(公告)日：2013-07-11
申请号：US13457821
申请日：2012-04-27
IPC分类号： A61K39/08
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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公开(公告)号：US20090041777A1
公开(公告)日：2009-02-12
申请号：US11890317
申请日：2007-08-02
申请人： William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人： William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
IPC分类号： A61K31/395 , C07K16/08 , C07H21/04 , C12N15/63 , C12N5/00 , A61K39/205 , C12Q1/70 , G01N33/566
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要： Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
摘要翻译： 本文提供了特异性结合狂犬病病毒的人单克隆抗体，其抗原结合部分，以及制备和使用此类抗体及其抗原结合部分用于治疗受试者中狂犬病病毒的方法。
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公开(公告)号：US20130039926A1
公开(公告)日：2013-02-14
申请号：US13553564
申请日：2012-07-19
申请人： William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
发明人： William D. Thomas, JR. , Donna M. Ambrosino , Robert Mandell , Susan Sloan , Gregory J. Babcock , Charles Rupprecht
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K39/42 , A61K2039/507 , C07K16/10 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N2760/20222 , C12N2760/20234
摘要： Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
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公开(公告)号：US20120288510A1
公开(公告)日：2012-11-15
申请号：US12527663
申请日：2008-02-13
申请人： Donna M. Ambrosino , William D. Thomas, JR. , Gregory J. Babcock , Teresa Broering , Susan Sloan
发明人： Donna M. Ambrosino , William D. Thomas, JR. , Gregory J. Babcock , Teresa Broering , Susan Sloan
IPC分类号： A61K39/395 , C12N5/00 , C12N15/63 , C12N15/13 , C07K14/02 , C07K16/00 , C07K16/18 , A61P31/12 , G01N33/53
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/505 , A61K2039/5258 , A61K2039/55566 , C07K14/005 , C07K2317/21 , C07K2317/34 , C12N2770/24222 , C12N2770/24234
摘要： Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与丙型肝炎病毒（HCV）结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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