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公开(公告)号：US06773928B1
公开(公告)日：2004-08-10
申请号：US09939884
申请日：2001-08-27
申请人： Ray Yin , H. Dupont Durst , Peter A. Emanuel , Gary L. Hagnauer
发明人： Ray Yin , H. Dupont Durst , Peter A. Emanuel , Gary L. Hagnauer
IPC分类号： G01N33543
CPC分类号： G01N33/54393 , Y10S436/823
摘要： Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface to improve the orientation of the ligand/receptor binding domains within the bioassay at the nanoscopic level. In a preferred embodiment, the molecularly compact polymer comprises a dendrimer polymer such as a fifth generation polyamidoamine dendrimer having exterior surface hydroxyl and amine functional groups, and the ligand/receptor comprises an antibody or Fab.
摘要翻译： 公开了用于提高生物测定性能的物质组成和方法。 更具体地说，物质组成包括能够在表面上自取向的分子致密聚合物 - 配体缀合物，以改善纳米级水平下生物测定中配体/受体结合结构域的取向。 在优选的实施方案中，分子致密聚合物包含树枝状聚合物，例如具有外表面羟基和胺官能团的第五代聚酰胺胺树枝状聚合物，并且配体/受体包含抗体或Fab。
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2.发明授权公开(公告)号：US07022289B1
公开(公告)日：2006-04-04
申请号：US09974436
申请日：2001-10-10
IPC分类号： B01L3/00
CPC分类号： B01L3/5029 , B01L2300/042 , B01L2300/047 , G01N1/02 , G01N2001/027 , G01N2001/028 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255
摘要： A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, safely transport the collected samples, safely dispense collected samples for analysis and provide optimum sample recovery. The sampling device is in the form of a leak proof container that comprises a lid and base. The lid contains a sterile absorbent collection means integrated into and positioned on the inside surface of the lid. The base contains a means to facilitate sample recovery from the absorbent collection means via compression and/or scraping of the absorbent collections means. Methods for employing the present invention are described herein.
摘要翻译： 一种独立的防漏采样装置和采用所述装置的试剂盒，用于从各种表面收集化学和生物样品。 本发明提供了一种采样装置和试剂盒，其可用于容易地收集化学和生物样品，安全运输收集的样品，安全地分配收集的样品进行分析并提供最佳的样品回收。 采样装置是防漏容器的形式，其包括盖和底座。 盖子包含集成在盖子的内表面上并定位在盖的内表面上的无菌吸收剂收集装置。 基底包含通过吸收收集装置的压缩和/或刮擦来促进从吸收收集装置回收样品的方法。 本文描述了使用本发明的方法。
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公开(公告)号：US5932449A
公开(公告)日：1999-08-03
申请号：US792824
申请日：1997-01-30
CPC分类号： C07K16/1282 , C07K2317/55 , C07K2319/00
摘要： Recombinant antibody fragments (rFabs) specific to botulinum types A and Boxin complexes are provided. These rFabs are useful as immunosensors for detecting botulinum toxin in food, health care, and military applications. The DNA sequences coding for the rFabs are also disclosed.
摘要翻译： 提供了特异于A型和B型毒素复合物的重组抗体片段（rFab）。 这些rFab可用作检测食品，保健和军事应用中的肉毒杆菌毒素的免疫传感器。 还公开了编码rFab的DNA序列。
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4.发明授权公开(公告)号：US07393694B1
公开(公告)日：2008-07-01
申请号：US11264337
申请日：2005-10-26
IPC分类号： G01N1/00
CPC分类号： B01L3/5029 , B01L2300/042 , B01L2300/047 , G01N1/02 , G01N2001/027 , G01N2001/028 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255
摘要： A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, safely transport the collected samples, safely dispense collected samples for analysis and provide optimum sample recovery. The sampling device is in the form of a leak proof container that comprises a lid and base. The lid contains a sterile absorbent collection means integrated into and positioned on the inside surface of the lid. The base contains a means to facilitate sample recovery from the absorbent collection means via compression and/or scraping of the absorbent collections means. Methods for employing the present invention are described herein.
摘要翻译： 一种独立的防漏采样装置和采用所述装置的试剂盒，用于从各种表面收集化学和生物样品。 本发明提供了可用于容易地收集化学和生物样品，安全运输收集的样品的采样装置和试剂盒，安全地分配收集的样品用于分析并提供最佳的样品回收。 采样装置是防漏容器的形式，其包括盖和底座。 盖子包含集成在盖子的内表面上并定位在盖的内表面上的无菌吸收剂收集装置。 基底包含通过吸收收集装置的压缩和/或刮擦来促进从吸收收集装置回收样品的方法。 本文描述了使用本发明的方法。
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