公开(公告)号：US06773928B1

公开(公告)日：2004-08-10

申请号：US09939884

申请日：2001-08-27

申请人： Ray Yin ,  H. Dupont Durst ,  Peter A. Emanuel ,  Gary L. Hagnauer

发明人： Ray Yin ,  H. Dupont Durst ,  Peter A. Emanuel ,  Gary L. Hagnauer

IPC分类号： G01N33543

CPC分类号： G01N33/54393 ,  Y10S436/823

摘要： Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface to improve the orientation of the ligand/receptor binding domains within the bioassay at the nanoscopic level. In a preferred embodiment, the molecularly compact polymer comprises a dendrimer polymer such as a fifth generation polyamidoamine dendrimer having exterior surface hydroxyl and amine functional groups, and the ligand/receptor comprises an antibody or Fab.

摘要翻译： 公开了用于提高生物测定性能的物质组成和方法。 更具体地说，物质组成包括能够在表面上自取向的分子致密聚合物 - 配体缀合物，以改善纳米级水平下生物测定中配体/受体结合结构域的取向。 在优选的实施方案中，分子致密聚合物包含树枝状聚合物，例如具有外表面羟基和胺官能团的第五代聚酰胺胺树枝状聚合物，并且配体/受体包含抗体或Fab。

公开(公告)号：US06716450B1

公开(公告)日：2004-04-06

申请号：US09859260

申请日：2001-05-17

申请人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

发明人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

IPC分类号： A61K948

CPC分类号： A61K9/5146 ,  A61K31/74 ,  A61K31/765

摘要： Nanocapsules useful for encapsulating bioactive molecules such as proteins are disclosed. These nanocapsules are comprised of branched or hyperbranched polymers and copolymers and have a core-shell structure forming a pocket volume appropriate for complexing and retaining enzymes and other bioactive molecules. The nanoencapsulated bioactive molecule is stable in extreme temperatures and pH, soluble in aqueous or organic solvents, and can be lyophilized to a dry powder for long-term storage without loss of enzyme activity.

摘要翻译： 公开了可用于包封生物活性分子如蛋白质的纳米胶囊。 这些纳米胶囊由支链或超支化聚合物和共聚物组成，并且具有形成适于络合和保留酶和其它生物活性分子的口袋体积的核 - 壳结构。 纳米封装的生物活性分子在极端温度和pH下是稳定的，可溶于水溶液或有机溶剂，并且可以冻干至干燥粉末以进行长期保存而不损失酶活性。

公开(公告)号：US08278495B1

公开(公告)日：2012-10-02

申请号：US12024629

申请日：2008-02-01

申请人： Daniel Waysbort ,  William R. Creasy ,  H. Dupont Durst ,  David J. McGarvey

发明人： Daniel Waysbort ,  William R. Creasy ,  H. Dupont Durst ,  David J. McGarvey

IPC分类号： A62D3/00 ,  B09B1/00 ,  B09B3/00 ,  C21B3/06

CPC分类号： A62D3/38 ,  A62D2101/02 ,  B09B3/0025

摘要： A chemical warfare (CW) agent decontamination system and method for decontaminated surfaces contaminated by CW agents. The system includes both solid particles and liquid solution in admixture such that the solid particles absorb the liquid decontamination material. The method of decontaminating surfaces contaminated with CW agents includes contacting the CW agent with a sufficient amount of a solid-particle sorbent for a sufficient time and under conditions which are sufficient to produce a reaction product having less toxicity than the CW agent. CW agents to be decontaminated include the nerve agents VX and G-type agents, and mustard agent HD. The system is non-toxic and has a reduced environmental impact as compared to the previously available decontamination systems and solutions.

摘要翻译： 化学战（CW）代理净化系统和污染表面污染CW剂的方法。 该系统包括固体颗粒和混合液体溶液，使得固体颗粒吸收液体去污材料。 用CW剂污染表面的污染方法包括使CW试剂与足够量的固体颗粒吸附剂接触足够的时间和足以产生毒性低于CW试剂的反应产物的条件下。 要去污的CW试剂包括神经药剂VX和G型药剂和芥子剂HD。 与以前可用的去污系统和解决方案相比，该系统是无毒的并且具有减少的环境影响。

公开(公告)号：US08592758B1

公开(公告)日：2013-11-26

申请号：US13153832

申请日：2011-06-06

申请人： John M. Nilles ,  Theresa R. Connell ,  H. Dupont Durst

发明人： John M. Nilles ,  Theresa R. Connell ,  H. Dupont Durst

IPC分类号： H01J49/00 ,  H01J49/10

CPC分类号： H01J49/0431

摘要： A vapor sampling adapter for direct analysis in real time mass spectrometer (DART-MS) applications comprises a vapor transport line and a manifold. In the preferred embodiment the vapor transport line is heated and approximately 20 feet in length. This provides a means to utilize the highly accurate and reliable DART-MS device to detect chemical agents at sample location points up to 20 feet away from the device with the ability to easily move the sampling point to any desired point within the sampling range, thus allowing the operator to systematically scan a site in a fashion similar to that used with a handheld detector. Sample vapor flows through the vapor transport line to the manifold where it comes in proximity to the ion generator of the DART mass spectrometer before entering into the mass spectrometer for analysis. The present invention may be used to raster a surface to determine the precise location of chemical agent contamination. Additionally, the invention may be used to tune or calibrate a DART-MS.

摘要翻译： 用于在实时质谱仪（DART-MS）应用中直接分析的蒸气取样适配器包括蒸气输送管线和歧管。 在优选实施例中，蒸汽输送管线被加热并且长度大约为20英尺。 这提供了一种方法来利用高度精确和可靠的DART-MS设备来检测距离设备高达20英尺的样品位置点处的化学试剂，能够将采样点轻松移动到采样范围内的任何所需点，因此 允许操作员以类似于手持式探测器使用的方式系统地扫描站点。 样品蒸汽通过蒸气输送管线流入歧管，在进入质谱仪进行分析之前，它接近DART质谱仪的离子发生器。 本发明可用于光栅化表面以确定化学剂污染的精确位置。 另外，本发明可用于调整或校准DART-MS。

公开(公告)号：US07186877B1

公开(公告)日：2007-03-06

申请号：US11240782

申请日：2005-09-27

申请人： Kevin M. Morrissey ,  H. Dupont Durst ,  Lucille P. Forrest ,  Mary P. Weiss

发明人： Kevin M. Morrissey ,  H. Dupont Durst ,  Lucille P. Forrest ,  Mary P. Weiss

IPC分类号： A62D3/00

CPC分类号： A62D3/38 ,  A62D2101/02 ,  A62D2101/06 ,  C02F1/72 ,  C02F11/004

摘要： Methods and systems for processing vesicants as well as other irritants are described. In some methods a vesicant, for example, a Lewisite such as the L1 form, the L2 form, L3 form, or combination thereof, is combined with permanganate, for example, as an aqueous solution of sodium permanganate. The methods can include releasing the vesicants or irritants from a munition, for example, by explosively rupturing the munition.

摘要翻译： 描述了用于处理泡沫以及其它刺激物的方法和系统。 在一些方法中，例如，将诸如L1形式的Lewisite，L2形式，L3形式或其组合的发泡剂与高锰酸盐组合，例如作为高锰酸钠的水溶液。 这些方法可以包括从弹药中释放出泡沫或刺激物，例如爆炸性地破坏弹药。