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公开(公告)号：US08740891B2
公开(公告)日：2014-06-03
申请号：US12744001
申请日：2008-11-19
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
摘要翻译： 一种柔性多管式冷冻探针，包括用于接收来自流体源的近临界低温流体的入口流并用于排出低温流体出口流的壳体。 多个流体输送管被牢固地附接到壳体。 这包括一组入口流体输送管，用于从壳体接收入口流; 以及用于将出口流排放到壳体的一组出口流体输送管。 每个流体输送管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。 每个流体输送管的内径在约0.10mm至1.0mm之间的范围内，壁厚在约0.01mm至0.30mm的范围内。 端盖定位在多个流体输送管的端部，以提供从入口流体输送管到出口流体输送管的流体转移。
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公开(公告)号：US20110162390A1
公开(公告)日：2011-07-07
申请号：US13046274
申请日：2011-03-11
CPC分类号： A61B18/02 , A61B2018/0262 , F25B9/02 , F25B2309/021
摘要： Methods and systems are provided for cooling an object with a cryogen having a critical point defined by a critical-point pressure and a critical-point temperature. A pressure of the cryogen is raised above a pressure value determined to provide the cryogen at a reduced molar volume that prevents vapor lock. Thereafter, the cryogen is placed in thermal communication with the object to increase a temperature of the cryogen along a thermodynamic path that maintains the pressure greater than the critical-point pressure for a duration that the cryogen and object are in thermal communication.
摘要翻译： 提供了用具有由临界点压力和临界点温度限定的临界点的冷冻剂冷却物体的方法和系统。 冷冻剂的压力升高到高于确定为以减少的摩尔体积提供冷冻剂以防止气体锁定的压力值。 此后，冷冻剂被放置成与物体热连通，以在致冷剂和物体处于热连通的持续时间内沿着保持压力大于临界点压力的热力学路径增加冷冻剂的温度。
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公开(公告)号：US07458379B2
公开(公告)日：2008-12-02
申请号：US11217553
申请日：2005-09-01
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00132 , A61B2017/00199 , A61B2018/00041 , A61B2090/378
摘要： A cryosurgical system adapted for treatment of fibroadenomas within the breast of a patient. The system includes cryoprobes and a control system which operates the cryoprobes to accomplish freezing in two stages, including a high power freeze and a low power freeze.
摘要翻译： 适用于治疗患者乳房内纤维腺瘤的冷冻手术系统。 该系统包括冷冻探针和控制系统，其操作冷冻探针以两个阶段完成冷冻，包括高功率冻结和低功率冷冻。
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4.发明申请Method and Apparatus for Categorizing Breast Density and Assessing Cancer Risk Utilizing Acoustic Parameters 有权用于分类乳腺密度和评估使用声学参数的癌症风险的方法和装置公开(公告)号：US20080275344A1
公开(公告)日：2008-11-06
申请号：US12115174
申请日：2008-05-05
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B5/4312 , A61B8/14 , A61B8/406
摘要： A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.
摘要翻译： 公开了一种分类全乳密度的方法。 该方法包括将乳房组织暴露于声信号的步骤; 通过分析声学信号来测量声学参数的分布; 并从所述测量步骤获得全乳房密度的量度。 还公开了一种装置。
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公开(公告)号：US07083612B2
公开(公告)日：2006-08-01
申请号：US10757769
申请日：2004-01-14
IPC分类号： A61B18/02
CPC分类号： F25D3/10 , A61B18/02 , A61B18/0218 , A61B2018/00017 , A61B2018/00023 , A61B2018/0262 , A61B2018/0293
摘要： A cryotherapy system is provided with multiple cryoprobes, each of which has a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end. A source is provided for the cryogenic fluid, and flow-control metering valves are provided in fluid communication with the conduits and source of the cryogenic fluid. A compressor is provided in fluid communication with the conduits of the cryoprobes to define a self-contained fluid system. The flow-control metering valves and the compressor are controlled by a computer processor to provide the desired flows of the cryogenic fluid through the conduits of the self-contained fluid system.
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6.发明授权Method and apparatus for categorizing breast density and assessing cancer risk utilizing acoustic parameters 有权使用声学参数分类乳房密度和评估癌症风险的方法和装置公开(公告)号：US08870771B2
公开(公告)日：2014-10-28
申请号：US12115174
申请日：2008-05-05
CPC分类号： A61B8/0825 , A61B5/4312 , A61B8/14 , A61B8/406
摘要： A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.
摘要翻译： 公开了一种分类全乳密度的方法。 该方法包括将乳房组织暴露于声信号的步骤; 通过分析声学信号来测量声学参数的分布; 并从所述测量步骤获得全乳房密度的量度。 还公开了一种装置。
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公开(公告)号：US20140221991A1
公开(公告)日：2014-08-07
申请号：US14087947
申请日：2013-11-22
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00529 , A61B2018/00547 , A61B2018/00577 , A61B2018/0262
摘要： A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.
摘要翻译： 一种冷却材料的方法，包括以下步骤：（i）提供冷冻治疗仪器，（ii）将冷冻治疗仪器的一部分定位在待冷却材料附近，以及（iii）在物理条件下使低温流体通过冷冻治疗仪器循环 在低温液体的液体 - 蒸汽系统的临界点附近。 临界点定义了液体 - 蒸气系统的相图中的一个点，其中摩尔体积对于液体和气体基本相当，从而避免了与冷冻治疗仪器的冷却相关的蒸汽锁定。
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公开(公告)号：US07959625B2
公开(公告)日：2011-06-14
申请号：US12857757
申请日：2010-08-17
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00132 , A61B2017/00199 , A61B2018/00041 , A61B2090/378
摘要： A cryosurgical system adapted for treatment of fibroadenomas within the breast of a patient. The system includes cryoprobes and a control system which operates the cryoprobes to accomplish freezing in two stages, including a high power freeze and a low power freeze.
摘要翻译： 适用于治疗患者乳房内纤维腺瘤的冷冻手术系统。 该系统包括冷冻探针和控制系统，其操作冷冻探针以两个阶段完成冷冻，包括高功率冻结和低功率冷冻。
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公开(公告)号：US20110040297A1
公开(公告)日：2011-02-17
申请号：US12744001
申请日：2008-11-19
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
摘要翻译： 一种柔性多管式冷冻探针，包括用于接收来自流体源的近临界低温流体的入口流并用于排出低温流体出口流的壳体。 多个流体输送管被牢固地附接到壳体。 这包括一组入口流体输送管，用于从壳体接收入口流; 以及用于将出口流排放到壳体的一组出口流体输送管。 每个流体输送管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。 每个流体输送管的内径在约0.10mm至1.0mm之间的范围内，壁厚在约0.01mm至0.30mm的范围内。 端盖定位在多个流体输送管的端部，以提供从入口流体输送管到出口流体输送管的流体转移。
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公开(公告)号：US20090270851A1
公开(公告)日：2009-10-29
申请号：US12425938
申请日：2009-04-17
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0262
摘要： A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.
摘要翻译： 提供一种系统及其使用方法，用于冷却探针远端处的冷冻液用于冷冻手术。 特别地，冷冻液被液体制冷剂冷却至低温，以便对生物组织进行冷冻手术。 该系统是闭环的，并且在液体制冷剂通过整个系统的过程中，液体制冷剂总是在相对低的压力下保持在液态。
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