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公开(公告)号：US20110217334A1
公开(公告)日：2011-09-08
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K39/35 , C07K14/415 , C12N15/63 , C07H21/00 , A61P37/08
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v Ia.
摘要翻译： 本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v Ia具有至少40％同一性的变应原的相应区域。
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公开(公告)号：US09040054B2
公开(公告)日：2015-05-26
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K36/00 , A61K39/00 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K14/415
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.
摘要翻译： 本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v 1a具有至少40％同一性的变应原的相应区域。
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公开(公告)号：US20140242668A1
公开(公告)日：2014-08-28
申请号：US14131593
申请日：2012-07-09
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12Y402/02
摘要： The present invention relates to a variant of a mature polysaccharide lyase having a beta helix structure, wherein said variant comprises an N- and/or C-terminal truncation and consists essentially of at least 90% of the beta helix structure of the mature polysaccharide lyase.
摘要翻译： 本发明涉及具有β螺旋结构的成熟多糖裂解酶的变体，其中所述变体包含N-和/或C-末端截短并且基本上由至少90％的成熟多糖裂解酶的β螺旋结构组成 。
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4.发明授权公开(公告)号：US06984726B1
公开(公告)日：2006-01-10
申请号：US09647234
申请日：1999-03-25
申请人： Fatima Ferreira , Klaus Richter , Martin Himly , Edwin Engel , Christof Ebner , Michael Breitenbach , Dietrich Kraft
发明人： Fatima Ferreira , Klaus Richter , Martin Himly , Edwin Engel , Christof Ebner , Michael Breitenbach , Dietrich Kraft
IPC分类号： C07H21/04
CPC分类号： C07K14/415 , A61K39/00
摘要： The invention relates to DNA molecules which code for the allergen Art v 1 or isoforms thereof, the sequence of the allergen, a method for the production of an Art v 1 molecule, a vector and a transformed host cell.
摘要翻译： 本发明涉及编码变应原Art v 1或其同工型的DNA分子，变应原的序列，Art v 1分子的生产方法，载体和转化的宿主细胞。
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