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    Cyclopentane derivatives
    2.
    发明授权
    Cyclopentane derivatives 失效
    环戊烷衍生物

    公开(公告)号：US4045467A

    公开(公告)日：1977-08-30

    申请号：US573107

    申请日：1975-04-30

    申请人： Michael Peter Lear Caton ,  Trevor Parker

    发明人： Michael Peter Lear Caton ,  Trevor Parker

    IPC分类号： C07C405/00 ,  C07D317/72 ,  C07F9/40 ,  C07F9/54 ,  C07C177/00

    CPC分类号： C07D317/72 ,  C07C405/00 ,  C07C405/0025 ,  C07F9/4006 ,  C07F9/54 ,  C07F9/5407

    摘要： Cyclopentane derivatives of the formula: ##STR1## (wherein the R symbols represent hydrogen or alkyl, n represents 4 or 6, and the symbols A, B, X and Y have any one of the following combinations: (a) A represents methylene, B represents hydroxymethylene, X represents ethylene and Y represents hydroxymethylene; (b) A represents carbonyl, B represents methylene, X represents ethylene or trans-vinylene and Y represents hydroxymethylene or carbonyl; or (c) A represents hydroxymethylene, B represents methylene, X represents ethylene or trans-vinylene and Y represents hydroxymethylene) are new compounds, possessing pharmacological properties, in particular, the production of hypotension, bronchodilatation, inhibition of gastric acid secretion and stimulation of uterine contraction.

    摘要翻译： 下式的环戊烷衍生物（其中R符号表示氢或烷基，n表示4或6，符号A，B，X和Y具有以下组合之一：（a）A表示亚甲基， B表示羟基亚甲基，X表示乙烯，Y表示羟基亚甲基;（b）A表示羰基，B表示亚甲基，X表示亚乙基或反式亚乙烯基，Y表示羟基亚甲基或羰基;或（c）A表示羟基亚甲基，B表示亚甲基，X 代表乙烯或反式亚乙烯基，Y代表羟基亚甲基）是具有药理学特性的新化合物，特别是产生低血压，支气管扩张，抑制胃酸分泌和刺激子宫收缩。

    Cyclopentane derivatives
    3.
    发明授权
    Cyclopentane derivatives 失效
    环戊烷衍生物

    公开(公告)号：US4036872A

    公开(公告)日：1977-07-19

    申请号：US523015

    申请日：1974-11-12

    申请人： Michael Peter Lear Caton ,  Edward Charles John Coffee ,  Gordon Leonard Watkins

    发明人： Michael Peter Lear Caton ,  Edward Charles John Coffee ,  Gordon Leonard Watkins

    IPC分类号： C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D309/12 ,  C07D317/72 ,  C07C177/00

    CPC分类号： C07D317/72 ,  C07C405/00 ,  C07D309/12

    摘要： Cyclopentane derivatives of the formula: ##STR1## wherein R.sup.1 represents alkyl of 1 through 4 carbon atoms, R.sup.2 represents hydrogen or alkyl of 1 through 3 carbon atoms, R.sup.3 represents alkoxy of 3 through 6 carbon atoms, or alkoxyalkyl in which alkoxy and alkyl moieties each contain 1 through 4 carbon atoms, R.sup.4 represents hydrogen or alkyl of 1 through 12 carbon atoms, R.sup.5 represents hydrogen or alkyl of 1 through 4 carbon atoms or a carboxylic acyl group, A represents carbonyl or a group --CH(OR.sup.5)-- wherein R.sup.5 is as hereinbefore defined, and X represents ethylene or trans-vinylene, possess pharmacological properties, for example the production of hypotension, broncodilation, inhibition of gastric acid secretion, and stimulation of uterine contraction.

    摘要翻译： 下式的环戊烷衍生物：其中R 1表示1至4个碳原子的烷基，R 2表示氢或1至3个碳原子的烷基，R 3表示3至6个碳原子的烷氧基，或烷氧基烷基，其中烷氧基和烷基部分 各自含有1至4个碳原子，R4表示氢或1至12个碳原子的烷基，R5表示氢或1至4个碳原子的烷基或羧酰基，A表示羰基或基团-CH（OR5） - ，其中 R5如上所定义，X代表亚乙基或反式亚乙烯基，具有药理学性质，例如产生低血压，支气管扩张，抑制胃酸分泌和刺激子宫收缩。

    Cyclopentane derivatives
    7.
    发明授权
    Cyclopentane derivatives 失效
    环戊烷衍生物

    公开(公告)号：US3935261A

    公开(公告)日：1976-01-27

    申请号：US502976

    申请日：1974-09-03

    申请人： Michael Peter Lear Caton ,  Edward Charles John Coffee ,  Gordon Leonard Watkins

    发明人： Michael Peter Lear Caton ,  Edward Charles John Coffee ,  Gordon Leonard Watkins

    IPC分类号： C07C45/00 ,  C07C243/28 ,  C07C405/00 ,  C07F9/54 ,  C07C102/00 ,  C07C103/37

    CPC分类号： C07C405/00 ,  C07C243/28 ,  C07C45/00 ,  C07F9/5407 ,  C07C2101/08

    摘要： Cyclopentane derivatives of the prostaglandin type of the formula: ##SPC1##(wherein R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents alkyl of 1 to 10 carbon atoms, the symbols R.sup.3 are the same and represent hydrogen, lower alkyl, lower alkenyl, phenyl(lower)alkyl or lower alkanoyl, R.sup.4 represents a carboxy or alkoxycarbonyl group, or an amido group unsubstituted or substituted on the nitrogen atom, X represents vinylene, ethylene, epoxyethylene or cyclopropylene, and n represents an integer of 5 to 8), which possess pharmacological properties in particular the production of hypotension, bronchodilation, inhibition of gastric acid secretion and stimulation of uterine contraction are prepared by a new six-stage process involving initially the reaction of an enamine of a cyclopentanone with an aldehyde to form a 2-hydroxyalkyl-2-cyclopenten-1-one, reacting the cyclopentenone with a source of hydrogen cyanide to form a hydroxyalkyl-3-oxocyclopentane-carbonitrile, reducing the carbonitrile to a 3-hydroxy-2-hydroxyalkyl-cyclopentanecarbaldehyde, reacting the carbaldehyde with an alkanoylmethylenephosphorane to convert the formyl group to ------CH=CH --CO--R.sup.2, oxidising the terminal hydroxymethyl group in the 2-position substituent to carboxy and the ring hydroxy group to oxo, and reducing the two oxo groups in the resulting cyclopentanonealkanoic acid to yield a 2-hydroxy-5-(3-hydroxyalkenyl)cyclopentyl-alkanoic acid, and optionally converting the product into another compound of the foregoing formula.

    摘要翻译： 环戊烷衍生物的前列腺素类型为：

    10,11,15-Trihydroxyprostanoic acid
    8.
    发明授权
    10,11,15-Trihydroxyprostanoic acid 失效
    10,11,15-三羟基雄甾烷酸

    公开(公告)号：US3933890A

    公开(公告)日：1976-01-20

    申请号：US423376

    申请日：1973-12-07

    申请人： Michael Peter Lear Caton ,  Trevor Parker

    发明人： Michael Peter Lear Caton ,  Trevor Parker

    IPC分类号： C07C405/00 ,  C07F9/40 ,  C07F9/54 ,  C07C61/38 ,  C07C69/74

    CPC分类号： C07F9/4006 ,  C07C405/00 ,  C07F9/5407

    摘要： Cyclopentane derivatives of the formula: ##SPC1##(wherein the R symbols represent hydrogen or alkyl, n represents 4 or 6, and the symbols A, B, X and Y have any one of the following combinations: (a) A represents methylene, B represents hydroxymethylene, X represents ethylene and Y represents hydroxymethylene; (b) A represents carbonyl, B represents methylene, X represents ethylene or trans-vinylene and Y represents hydroxymethylene or carbonyl; or (c) A represents hydroxymethylene, B represents methylene, X represents ethylene or trans-vinylene and Y represents hydroxymethylene) are new compounds, possessing pharmacological properties, in particular, the production of hypotension, bronchodilatation, inhibition of gastric acid secretion and stimulation of uterine contraction.

    摘要翻译： 环戊烷衍生物的结构式如下：