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公开(公告)号：US07335773B2
公开(公告)日：2008-02-26
申请号：US11276074
申请日：2006-02-13
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: C07D471/02
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号：US06894165B2
公开(公告)日：2005-05-17
申请号：US10824232
申请日：2004-04-14
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00 , C07D471/12 , C07D471/00
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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公开(公告)号：US06514985B1
公开(公告)日：2003-02-04
申请号：US09706990
申请日：2000-11-06
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: A61K314353
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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Patent Agency Ranking
公开(公告)号：US06194425B1
公开(公告)日：2001-02-27
申请号：US09210114
申请日：1998-12-11
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: C07D47102
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号：US07038051B2
公开(公告)日：2006-05-02
申请号：US11188418
申请日：2005-07-25
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: C07D471/12 , C07D471/00
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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公开(公告)号：US07678918B2
公开(公告)日：2010-03-16
申请号：US11999602
申请日：2007-12-06
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: C07D411/02
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号：US06949646B2
公开(公告)日：2005-09-27
申请号：US11004674
申请日：2004-12-03
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号：US06797716B2
公开(公告)日：2004-09-28
申请号：US10406181
申请日：2003-04-03
Applicant: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
Inventor： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC: A61K31437
CPC classification number: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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