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    Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof
    4.
    发明申请
    Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof 有权
    基因工程梭菌基因，由工程基因编码的蛋白质及其用途

    公开(公告)号：US20060204524A1

    公开(公告)日：2006-09-14

    申请号：US11284930

    申请日：2005-11-22

    申请人： Konstantin Ichtchenko ,  Philip Band

    发明人： Konstantin Ichtchenko ,  Philip Band

    IPC分类号： A61K39/08 ,  C07K14/33

    CPC分类号： C12N9/52 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/6037 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469

    摘要： The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed.

    摘要翻译： 本发明涉及具有轻链区域的轻链和重链区域通过二硫键连接的轻链区域和连接轻链区域和重链区域的中间区域的分离的梭菌神经毒素前肽。 还公开了编码梭菌神经毒素前肽的分离的核酸分子。 还公开了通过切割梭菌神经毒素前肽，疫苗或解毒剂产生的分离的，生理活性的梭菌神经毒素，以及针对或治疗梭菌神经毒素的毒性作用的方法。 还公开了表达重组生理活性梭菌神经毒素的方法。 还公开了具有梭菌神经毒素的重链区域和具有治疗功能的蛋白质的嵌合蛋白质。 还公开了一种治疗方法。

    Hylan preparation and method of recovery thereof from animal tissues
    8.
    发明授权
    Hylan preparation and method of recovery thereof from animal tissues 失效
    Hylan制剂及其从动物组织中回收的方法

    公开(公告)号：US5099013A

    公开(公告)日：1992-03-24

    申请号：US616706

    申请日：1990-11-16

    申请人： Endre A. Balazs ,  Adolf Leshchiner ,  Adelya Leshchiner ,  Nancy Larsen ,  Philip Band

    发明人： Endre A. Balazs ,  Adolf Leshchiner ,  Adelya Leshchiner ,  Nancy Larsen ,  Philip Band

    IPC分类号： C08B37/08

    CPC分类号： C08B37/0072

    摘要： Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.

    摘要翻译： 公开了一种化学改性的透明质酸制剂，其特征在于存在少量（0.0002-0.05重量％）共价结合到透明质酸分子链上的醛交联基团。 还公开了一种获得hylan的改进方法，其包括用包含对透明质酸和包含在动物组织中的蛋白质具有反应性的醛的处理混合物在原位处理透明质酸的动物组织。 在非常高的pH（例如8-14）下，在低于约16℃的温度下进行处理，由此总体收率提高同时保持高分子量的木聚糖。