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    Tumor necrosis factor stimulated gene 6 (TSG-6) protein
    2.
    发明授权
    Tumor necrosis factor stimulated gene 6 (TSG-6) protein 失效
    肿瘤坏死因子刺激基因6（TSG-6）蛋白

    公开(公告)号：US06518401B2

    公开(公告)日：2003-02-11

    申请号：US09799118

    申请日：2001-03-06

    申请人： Tae Ho Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    发明人： Tae Ho Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    IPC分类号： C07K14435

    CPC分类号： C07K14/4718

    摘要： TSG protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.

    摘要翻译： 提供TSG蛋白及其功能性衍生物，编码DNA，表达载体如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及TSG- 6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

    Tumor necrosis factor-induced protein TSG-6
    3.
    发明授权
    Tumor necrosis factor-induced protein TSG-6 失效
    肿瘤坏死因子诱导蛋白TSG-6

    公开(公告)号：US5386013A

    公开(公告)日：1995-01-31

    申请号：US24868

    申请日：1993-03-01

    申请人： Tae H. Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    发明人： Tae H. Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    IPC分类号： C12N1/21 ,  C07K14/47 ,  C07K16/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/53 ,  G01N33/577 ,  C07K13/00 ,  C12P21/06

    CPC分类号： C07K14/4718

    摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. The TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided. Antibodies specific for the TSG-6 protein are disclosed, as is a method for detecting the presence of TSG-6 protein in a biological sample, using the antibody or another molecule capable of binding to TSG-6 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein, a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-6 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.

    摘要翻译： 多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。 提供TSG-6蛋白质及其功能性衍生物，编码它们的DNA，表达载体，例如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法。 公开了对TSG-6蛋白质特异性的抗体，以及使用抗体或能够与TSG-6如透明质酸结合的另一分子来检测生物样品中TSG-6蛋白质的存在的方法。 用于检测编码正常或突变体TSG-6蛋白的核酸的存在的方法，使用核酸杂交或免疫测定法测定细胞中TSG-6表达的诱导方法，鉴定能诱导的化合物的方法 还提供了TSG-6在细胞中的表达，以及测定细胞对TNF反应能力的方法。

    Tumor necrosis factor stimulated gene 6 (TSG-6) binding molecules
    6.
    发明授权
    Tumor necrosis factor stimulated gene 6 (TSG-6) binding molecules 失效
    肿瘤坏死因子刺激基因6（TSG-6）结合分子

    公开(公告)号：US06210905B1

    公开(公告)日：2001-04-03

    申请号：US09206695

    申请日：1998-12-07

    申请人： Tae Ho Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    发明人： Tae Ho Lee ,  Hans-Georg Wisniewski ,  Jan Vilcek

    IPC分类号： G01N3353

    CPC分类号： C07K14/4718

    摘要： TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.

    摘要翻译： TSG-6蛋白及其功能衍生物，编码DNA，表达载体如质粒和用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及针对 TSG-6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 用于检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

    QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS
    7.
    发明申请
    QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS 审中-公开
    量化局部炎症活动及其用于预防疾病进展和定制治疗

    公开(公告)号：US20150204888A1

    公开(公告)日：2015-07-23

    申请号：US14537732

    申请日：2014-11-10

    申请人： Philip A. BAND ,  Hans-Georg WISNIEWSKI ,  Virginia BYERS KRAUS

    发明人： Philip A. BAND ,  Hans-Georg WISNIEWSKI ,  Virginia BYERS KRAUS

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2333/811 ,  G01N2400/40 ,  G01N2800/105 ,  G01N2800/56 ,  G01N2800/7095

    摘要： This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.

    摘要翻译： 本发明涉及一种预测受试者炎性病症进展的方法，其涉及提供包含透明质酸或其片段的培养基; 使来自受试者的流体样品与炎症状况接触，其中流体样品包含蛋白质或蛋白聚糖和转移剂; 在对流体样品中转移剂有效的条件下，将介质中的流体样品温育以介导重链从蛋白质或蛋白聚糖到透明质酸或其片段的转移以形成复合物; 使用抗体检测复合物的发生水平; 以及将来自所述检测的复合物的发生水平与参考标准进行比较，以预测受试者的炎症状态的进展。 还公开了定制炎性病症治疗和定量体液中的局部炎症活性的方法。

    Pharmaceutical compositions containing TSG-6 for treating inflammatory diseases and cancer-related pathologies and method
    9.
    发明授权
    Pharmaceutical compositions containing TSG-6 for treating inflammatory diseases and cancer-related pathologies and method 失效
    含有TSG-6用于治疗炎性疾病和癌症相关病理学的药物组合物及方法

    公开(公告)号：US06313091B1

    公开(公告)日：2001-11-06

    申请号：US09000179

    申请日：1998-05-20

    申请人： Hans-Georg Wisniewski ,  Jan Vilcek ,  Bruce Cronstein

    发明人： Hans-Georg Wisniewski ,  Jan Vilcek ,  Bruce Cronstein

    IPC分类号： A61K3800

    CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K14/4718

    摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. TSG-6, or pharmaceutical compositions containing TSG-6, can be used to treat inflammatory diseases and disorders and cancer-related pathologies. Inflammatory diseases and disorders, or cancer related pathologies, can also be treated by introducing human cells transfected with a DNA molecule containing a DNA segment encoding TSG-6 protein, into humans to express therapeutically effective amounts of TSG-6 in vivo or by introducing a vector carrying a DNA segment encoding TSG-6 protein directly into humans in vivo.

    摘要翻译： 多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。 TSG-6或含有TSG-6的药物组合物可用于治疗炎性疾病和病症以及与癌症有关的病理学。 炎症性疾病和病症或癌症相关的病理学也可以通过将人DNA转导到含有编码TSG-6蛋白的DNA片段的DNA分子转染到人体内来表达治疗有效量的TSG-6或通过引入 将编码TSG-6蛋白质的DNA片段直接携带入人体内的载体。

    Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments
    10.
    发明授权
    Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments 有权
    量化局部炎症活动及其用于预测疾病进展和定制治疗的用途

    公开(公告)号：US08883427B2

    公开(公告)日：2014-11-11

    申请号：US13172300

    申请日：2011-06-29

    申请人： Philip A. Band ,  Hans-Georg Wisniewski ,  Virginia Byers Kraus

    发明人： Philip A. Band ,  Hans-Georg Wisniewski ,  Virginia Byers Kraus

    IPC分类号： G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2333/811 ,  G01N2400/40 ,  G01N2800/105 ,  G01N2800/56 ,  G01N2800/7095

    摘要： This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.

    摘要翻译： 本发明涉及一种预测受试者炎性病症进展的方法，其涉及提供包含透明质酸或其片段的培养基; 使来自受试者的流体样品与炎症状况接触，其中流体样品包含蛋白质或蛋白聚糖和转移剂; 在对流体样品中转移剂有效的条件下，将介质中的流体样品温育以介导重链从蛋白质或蛋白聚糖到透明质酸或其片段的转移以形成复合物; 使用抗体检测复合物的发生水平; 以及将来自所述检测的复合物的发生水平与参考标准进行比较，以预测受试者的炎症状态的进展。 还公开了定制炎性病症治疗和定量体液中的局部炎症活性的方法。