公开(公告)号：US20060122154A1

公开(公告)日：2006-06-08

申请号：US10520925

申请日：2003-07-18

申请人： David Olsen ,  Balkrishen Bhat ,  Philip Cook

发明人： David Olsen ,  Balkrishen Bhat ,  Philip Cook

IPC分类号： A61K31/675 ,  A61K31/519 ,  C07D487/02 ,  C07F9/6512

CPC分类号： A61K45/06 ,  C07H19/14

摘要： The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.

摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷类化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合含有这样的硫代核苷化合物的药物组合物。 还公开了用本发明的硫代核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

公开(公告)号：US06496744B1

公开(公告)日：2002-12-17

申请号：US09228458

申请日：1999-01-11

申请人： David Philip Cook

发明人： David Philip Cook

IPC分类号： G06F1900

CPC分类号： G06Q30/06 ,  G05B2219/32022 ,  G05B2219/32024 ,  G05B2219/32035 ,  G05B2219/32038 ,  G06Q30/0633

摘要： A system for selling, manufacturing and distributing a custom digital data product from retail stores, over the Internet, over the telephone, or by electronic means (e.g., fax, e-mail, and the like) wherein a customer is provided (e.g., by electronic mail verification) order tracking information. After a customer selects a “set” of sound recordings or data from a library or catalog of such recordings or data and payment or credit is received or verified, an image of the “set” is assembled from a storage or “disk” farm. The image is preferably assembled at a manufacturing facility, e.g., a CD-ROM burner farm, where the product is then made. Every data object on the product may have a code associated therewith for later reference. The disk and burner farms communicate via a high speed communications subsystem to facilitate continuous processing. Upon assembly and manufacture, the product is packaged and shipped. Throughout the manufacture and distribution, the customer may track the process by activating a hyperlink in one or more e-mail confirmation messages provided by the service provider, or by entering order/tracking numbers from retail terminals or by telephone, or the like.

摘要翻译： 一种用于从零售商店，互联网，电话或电子方式（例如传真，电子邮件等）销售，制造和分发定制数字数据产品的系统，其中提供了客户（例如， 通过电子邮件验证）订单跟踪信息。 在客户从图书馆或这些记录或数据的目录中选择“设置”的录音或数据之后，接收或验证支付或信用，从存储或“盘”场组装“集”的图像。 该图像优选地组装在制造设备，例如CD-ROM燃烧室，然后制造产品。 产品上的每个数据对象可能具有与之相关的代码供以后参考。 磁盘和燃烧器场通过高速通信子系统进行通信，以便于连续处理。 组装和制造后，产品被包装和运输。 在整个制造和分发过程中，客户可以通过激活由服务提供商提供的一个或多个电子邮件确认消息中的超链接，或者从零售终端或通过电话等输入订单/跟踪号码来跟踪该过程。

公开(公告)号：US5860068A

公开(公告)日：1999-01-12

申请号：US984907

申请日：1997-12-04

申请人： David Philip Cook

发明人： David Philip Cook

IPC分类号： G07F17/16 ,  G07F17/30 ,  G11B7/26 ,  G11B27/031 ,  G11B27/032 ,  G11B27/034 ,  G11B27/34 ,  G11B7/00

CPC分类号： G11B27/34 ,  G06Q20/12 ,  G06Q20/123 ,  G06Q30/0635 ,  G07F17/16 ,  G11B27/031 ,  G11B27/034 ,  G11B2220/213 ,  G11B2220/2545 ,  G11B2220/2562 ,  G11B2220/90 ,  G11B2220/913 ,  G11B27/032 ,  G11B7/26

摘要： A system for selling, manufacturing and distributing a custom digital data product from retail stores, over the Internet, over the telephone, or by electronic means (e.g., fax, e-mail, and the like) wherein a customer is provided (e.g., by electronic mail verification) order tracking information. After a customer selects a "set" of sound recordings or data from a library or catalog of such recordings or data and payment or credit is received or verified, an image of the "set" is assembled from a storage or "disk" farm. The image is preferably assembled at a manufacturing facility, e.g., a CD-ROM burner farm, where the product is then made. Every data object on the product may have a code associated therewith for later reference. The disk and burner farms communicate via a high speed communications subsystem to facilitate continuous processing. Upon assembly and manufacture, the product is packaged and shipped. Throughout the manufacture and distribution, the customer may track the process by activating a hyperlink in one or more e-mail confirmation messages provided by the service provider, or by entering order/tracking numbers from retail terminals or by telephone, or the like.