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    Thionucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
    1.
    发明申请
    Thionucleoside derivatives as inhibitors of rna-dependent rna viral polymerase 失效
    核苷衍生物作为rna依赖性rna病毒聚合酶的抑制剂

    公开(公告)号：US20060122154A1

    公开(公告)日：2006-06-08

    申请号：US10520925

    申请日：2003-07-18

    申请人： David Olsen ,  Balkrishen Bhat ,  Philip Cook

    发明人： David Olsen ,  Balkrishen Bhat ,  Philip Cook

    IPC分类号： A61K31/675 ,  A61K31/519 ,  C07D487/02 ,  C07F9/6512

    CPC分类号： A61K45/06 ,  C07H19/14

    摘要： The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷类化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合含有这样的硫代核苷化合物的药物组合物。 还公开了用本发明的硫代核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
    2.
    发明申请
    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase 审中-公开
    核苷衍生物作为rna依赖性rna病毒聚合酶的抑制剂

    公开(公告)号：US20060234962A1

    公开(公告)日：2006-10-19

    申请号：US10517294

    申请日：2003-06-23

    申请人： David Olsen ,  Malcolm MacCoss ,  Balkrishen Bhat ,  Anne Eldrup

    发明人： David Olsen ,  Malcolm MacCoss ,  Balkrishen Bhat ,  Anne Eldrup

    IPC分类号： A61K31/7076 ,  C07H19/16 ,  C07H19/22

    CPC分类号： C07H19/22 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
    3.
    发明申请
    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase 审中-公开
    核苷衍生物作为rna依赖性rna病毒聚合酶的抑制剂

    公开(公告)号：US20070004669A1

    公开(公告)日：2007-01-04

    申请号：US10517295

    申请日：2003-06-17

    申请人： Steven Carroll ,  David Olsen ,  Philippe Durette ,  Balkrishen Bhat ,  Prasad Dande ,  Anne Eldrup

    发明人： Steven Carroll ,  David Olsen ,  Philippe Durette ,  Balkrishen Bhat ,  Prasad Dande ,  Anne Eldrup

    IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04 ,  C07H19/167 ,  C07H19/12

    CPC分类号： C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/16 ,  C07H19/167 ,  C07H19/20

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
    4.
    发明申请
    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase 审中-公开
    核苷衍生物作为rna依赖性rna病毒聚合酶的抑制剂

    公开(公告)号：US20060264389A1

    公开(公告)日：2006-11-23

    申请号：US10521006

    申请日：2003-07-11

    申请人： Balkrishen Bhat ,  Steven Carroll ,  Anne Eldrup ,  Malcolm MacCoss ,  David Olsen ,  Thazha Prakash

    发明人： Balkrishen Bhat ,  Steven Carroll ,  Anne Eldrup ,  Malcolm MacCoss ,  David Olsen ,  Thazha Prakash

    IPC分类号： A61K31/7076 ,  C07H19/22

    CPC分类号： C07H19/14 ,  C07H19/22

    摘要： Thee present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA via replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or creating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是通过复制的RNA依赖性RNA的抑制剂，并且可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或用本发明的核苷化合物产生RNA依赖性RNA病毒感染的方法。

    Pear tree named ‘Olsen Bosc’
    7.
    植物专利
    Pear tree named ‘Olsen Bosc’ 有权

    公开(公告)号：USPP31444P2

    公开(公告)日：2020-02-18

    申请号：US16350847

    申请日：2019-01-22

    申请人： David Olsen

    发明人： David Olsen

    IPC分类号： A01H5/08 ,  A01H6/74

    摘要： The ‘Olsen Bosc’ pear tree, a mutation of ‘Bosc’, is notable for its distinctive fruit. Profound russeting on substantially the entire surface of the skin gives ‘Olsen Bosc’ pears a distinctive bronze appearance.

    Fluid cartridge
    8.
    发明授权
    Fluid cartridge 有权
    流体盒

    公开(公告)号：US08882252B2

    公开(公告)日：2014-11-11

    申请号：US13816695

    申请日：2010-10-22

    申请人： David C. Harvey ,  Curt Gonzales ,  Ralph L. Stathem ,  David Olsen ,  David Welter

    发明人： David C. Harvey ,  Curt Gonzales ,  Ralph L. Stathem ,  David Olsen ,  David Welter

    IPC分类号： B41J2/175

    CPC分类号： B41J2/17526 ,  B41J2/17513 ,  B41J2/1752 ,  B41J2/1755 ,  B41J2/17553

    摘要： An ink cartridge for an inkjet printer includes a bottom face and a front face; interfaces on the front face for connection to a cartridge receiving structure, the interfaces including an ink interface; a guide interface in the bottom face for guiding the cartridge along a straight line for connecting the interfaces; and a latch stop and a latch track, disposed in the bottom face, to guide and retain a latch of the cartridge receiving structure.

    摘要翻译： 用于喷墨打印机的墨盒包括底面和正面; 在前表面上的接口，用于连接到盒接收结构，所述接口包括墨接口; 位于底面的引导界面，用于沿着直线引导盒，用于连接接口; 以及设置在底面中的闩锁止动器和闩锁轨道，以引导和保持盒接收结构的闩锁。

    INTEGRATED MULTIFUNCTIONAL VALVE DEVICE
    10.
    发明申请
    INTEGRATED MULTIFUNCTIONAL VALVE DEVICE 有权
    集成多功能阀装置

    公开(公告)号：US20130271538A1

    公开(公告)日：2013-10-17

    申请号：US13977211

    申请日：2011-01-07

    申请人： Patrick V. Boyd ,  David Olsen ,  Milo A. Undlin

    发明人： Patrick V. Boyd ,  David Olsen ,  Milo A. Undlin

    IPC分类号： F16K31/16 ,  B41J2/175 ,  F16K7/16

    CPC分类号： F16K31/16 ,  B41J2/17513 ,  F16K7/16 ,  F16K17/14

    摘要： An integrated multifunctional valve device includes a surface member having a first port and a second port formed therein, a flexible disk member having a central portion and a surrounding portion, a first seat member extending outward from the surface member and coupled to the surrounding portion of the flexible disk member, a second seat member extending outward from the surface member and surrounded by the first seat member. The central portion is movable between an open port position to establish fluid communication between the respective ports and a close port position to stop the fluid communication between the respective ports. The second seat member is configured to selectively receive the central portion of the flexible disk member corresponding to the close port position. The integrated multifunctional valve device also includes an actuator member configured to selectively move the central portion of the flexible disk member into the open port position and the close port position.

    摘要翻译： 一种集成的多功能阀装置，包括具有形成在其中的第一端口和第二端口的表面构件，具有中心部分和周围部分的柔性盘构件，从表面构件向外延伸并连接到表面构件的周围部分的第一座构件 柔性盘构件，从表面构件向外延伸并被第一座构件包围的第二座构件。 中心部分可以在打开的端口位置之间移动，以在各个端口之间建立流体连通，以及关闭端口位置以停止各个端口之间的流体连通。 第二座椅构件被配置为选择性地接收对应于关闭端口位置的柔性盘构件的中心部分。 集成多功能阀装置还包括致动器构件，构造成选择性地将柔性盘构件的中心部分移动到打开端口位置和关闭端口位置。