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公开(公告)号：US20080064113A1
公开(公告)日：2008-03-13
申请号：US11784211
申请日：2007-04-04
申请人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held
发明人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held
CPC分类号： G01N21/6428 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/248 , C07K16/2803 , C07K16/2875 , G01N1/28 , G01N15/1459 , G01N27/447 , G01N33/582 , G01N33/68 , G01N35/1095 , G01N2015/1438 , G01N2035/1034 , Y10T436/13
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：US20060078998A1
公开(公告)日：2006-04-13
申请号：US11048660
申请日：2005-01-28
申请人： Robert Puskas , Richard Livingston , Douglas Held , Barbara Klein , Noelle Fukushima , Robert Freese , Philippe Goix , Peter David , Mickey Urdea
发明人： Robert Puskas , Richard Livingston , Douglas Held , Barbara Klein , Noelle Fukushima , Robert Freese , Philippe Goix , Peter David , Mickey Urdea
IPC分类号： G01N24/00
CPC分类号： G01N35/1095 , G01N1/28 , G01N15/1459 , G01N21/6428 , G01N27/447 , G01N33/68 , G01N33/6803 , G01N33/6845 , G01N2015/1438 , G01N2035/1034
摘要： The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要翻译： 本发明包括分析仪和分析仪系统，其包括单个粒子分析仪，使用分析仪和分析仪系统来分析样品的单颗粒或多颗粒（多路复用）的方法，基于使用分析仪进行生意的方法或 系统的分析器系统和用于存储在本发明的分析器和分析器系统中有用的参数的电子介质。
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公开(公告)号：US20080003685A1
公开(公告)日：2008-01-03
申请号：US11767196
申请日：2007-06-22
申请人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held
发明人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held
IPC分类号： G01N33/58
CPC分类号： G01N33/582
摘要： The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要翻译： 本发明包括分析器和分析仪系统，其包括单个粒子分析仪，使用分析仪和分析仪系统分析样品的方法，用于单个粒子，例如蛋白质分子，或用于多个粒子（复用），基于 使用系统的分析器或分析器系统，以及用于存储在本发明的分析器和分析器系统中有用的参数的电子介质。
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公开(公告)号：US07485888B2
公开(公告)日：2009-02-03
申请号：US10821727
申请日：2004-04-08
申请人： Philippe Goix , Paul J. Lingane
发明人： Philippe Goix , Paul J. Lingane
CPC分类号： G01N15/147 , G01N15/1434 , G01N21/645 , G01N2021/6421
摘要： A multicolor particle analyzer and method is described. The particles each of which either naturally fluoresce or are tagged to fluoresce at distinctive wavelengths are caused to flow through an analyzing volume where fluorescence is excited by an impinging light beam. A tunable optical filter repetitively and sequentially passes emitted light at each of the characteristic wavelengths as each particle travels through the analyzing volume and the light transmitted through the optical filter is received by single detector which provides output signals representative of each distinct wavelength of light emitted by the particle.
摘要翻译： 描述了一种多色粒子分析仪和方法。 天然荧光或被标记以在特定波长发荧光的颗粒被引导流过分析体积，其中荧光被入射光束激发。 可调谐滤光器每个粒子通过分析体积重复地依次通过发射的每个特征波长的光，并且通过光学滤波器传输的光被单个检测器接收，该检测器提供表示由 颗粒。
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