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12 条记录 (耗时 0.044 秒)

    Diabetes-associated markers and methods of use thereof
    4.
    发明申请
    Diabetes-associated markers and methods of use thereof 审中-公开
    糖尿病相关标志物及其使用方法

    公开(公告)号：US20070259377A1

    公开(公告)日：2007-11-08

    申请号：US11788260

    申请日：2007-04-18

    申请人： Mickey Urdea ,  Michael McKenna ,  Patrick Arensdorf

    发明人： Mickey Urdea ,  Michael McKenna ,  Patrick Arensdorf

    IPC分类号： G01N33/53

    CPC分类号： G01N33/48714 ,  G01N2800/52

    摘要： Disclosed are methods of identifying subjects with Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes, pre-Diabetes, or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk of progression to Diabetes, pre-Diabetes, or a pre-diabetic condition in patients, methods of evaluating the effectiveness of treatments in subjects with Diabetes, pre-Diabetes, or a pre-diabetic condition, and methods of selecting therapies for treating Diabetes, pre-Diabetes or a pre-diabetic condition, using biomarkers.

    摘要翻译： 公开了鉴定患有糖尿病，糖尿病前期或糖尿病前期病症的受试者的方法，鉴定患有糖尿病，糖尿病前期或糖尿病前期疾病风险的受试者的方法，差异诊断与糖尿病相关疾病的方法， 糖尿病前期或其他疾病或糖尿病分类前期糖尿病状况，糖尿病进展史，糖尿病前期或糖尿病前期患者的评估方法 使用糖尿病，糖尿病前期或糖尿病前期患者进行治疗，以及使用生物标志物选择治疗糖尿病，糖尿病前期或糖尿病前期病症的治疗方法。

    Diabetes-associated markers and methods of use thereof
    5.
    发明申请
    Diabetes-associated markers and methods of use thereof 审中-公开
    糖尿病相关标志物及其使用方法

    公开(公告)号：US20070218519A1

    公开(公告)日：2007-09-20

    申请号：US11546874

    申请日：2006-10-11

    申请人： Mickey Urdea ,  Michael McKenna ,  Patrick Arensdorf

    发明人： Mickey Urdea ,  Michael McKenna ,  Patrick Arensdorf

    IPC分类号： G01N33/00

    CPC分类号： G01N33/5091 ,  G01N33/48714 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/52

    摘要： Disclosed are methods of identifying subjects with Diabetes or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk of progression to Diabetes or a pre-diabetic condition in patients, methods of evaluating the effectiveness of treatments in subjects with Diabetes or a pre-diabetic condition, and methods of selecting therapies for treating Diabetes or a pre-diabetic condition, using biomarkers.

    摘要翻译： 公开了鉴定患有糖尿病或糖尿病前病症的受试者的方法，识别患有糖尿病或糖尿病前期疾病风险的受试者的方法，差异诊断与糖尿病相关疾病或其他疾病或糖尿病前期病症的方法 糖尿病的亚分类，评估进展为糖尿病或糖尿病前期患者的风险的方法，评估糖尿病或糖尿病前期患者治疗有效性的方法，以及选择治疗糖尿病治疗方法 或使用生物标志物的糖尿病前期病症。

    Methods and compositions for detecting polynucleotides
    9.
    发明申请
    Methods and compositions for detecting polynucleotides 审中-公开
    用于检测多核苷酸的方法和组合物

    公开(公告)号：US20080096193A1

    公开(公告)日：2008-04-24

    申请号：US11362359

    申请日：2006-10-24

    申请人： Charles Robert Bupp ,  K. Yeon Choi ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Michael Zwick

    发明人： Charles Robert Bupp ,  K. Yeon Choi ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Michael Zwick

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07D417/02

    CPC分类号： C12Q1/6816 ,  C12Q2565/107

    摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/nucleic acid analog hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

    摘要翻译： 提供了确定样品中靶多核苷酸的存在或量的方法。 含有目标多聚核苷酸，与靶多核苷酸的靶核酸序列互补的核酸类似物的样品和在存在和不存在靶​​多核苷酸时光学性质的变化率不同的染料 /核酸类似物混合物组合以产生反应混合物。 将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/核酸类似物的类似反应混合物中的染料的光学性质变化率的参考值进行比较 混合以确定光学性质的相对变化率。 反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。

    Methods and compositions for detecting polynucleotides
    10.
    发明申请
    Methods and compositions for detecting polynucleotides 有权
    用于检测多核苷酸的方法和组合物

    公开(公告)号：US20070231821A1

    公开(公告)日：2007-10-04

    申请号：US11710667

    申请日：2007-02-23

    申请人： Charles Bupp ,  K. Choi ,  Rachel Holmes-Davis ,  Alexander Izmailov ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Brian Warner ,  Michael Zwick

    发明人： Charles Bupp ,  K. Choi ,  Rachel Holmes-Davis ,  Alexander Izmailov ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Brian Warner ,  Michael Zwick

    IPC分类号： C12Q1/68 ,  C07D417/02 ,  C07D413/02 ,  C07D401/02

    CPC分类号： C12Q1/6876 ,  C12Q1/6813 ,  C12Q2600/156

    摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

    摘要翻译： 提供了确定样品中靶多核苷酸的存在或量的方法。 含有靶多核苷酸，可包括核酸类似物并与靶多核苷酸的靶核酸序列互补的多核苷酸的样品和在存在和/或存在的情况下光学性质的变化率不同的染料 组合不存在靶多核苷酸/多核苷酸杂交体以产生反应混合物。 将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/多核苷酸杂化物的类似反应混合物中的染料的光学性质变化率的变化率的参考值进行比较 确定光学性质的相对变化率。 反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。