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33 条记录 (耗时 0.023 秒)

    Electronic commerce integration
    1.
    发明授权
    Electronic commerce integration 有权
    电子商务整合

    公开(公告)号：US08271356B1

    公开(公告)日：2012-09-18

    申请号：US12751562

    申请日：2010-03-31

    申请人： Guy Miller

    发明人： Guy Miller

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/0623 ,  G06Q30/00 ,  G06Q30/0601 ,  G06Q30/0625 ,  G06Q30/0639 ,  G06Q30/0641

    摘要： An information system environment is described that, among other things, facilitates integration of electronic commerce and physical store front retailer selling channels. In some realizations, the system includes a shopper accessible kiosk co-located with a physical store front retailer and an electronic commerce information service accessible from locations external to the physical store front retailer. Both access inventory information supplied from a suitable information service. The shopper accessible kiosk allows a user thereof to access inventory information particular to the physical store front retailer, while the electronic commerce information service allows a user thereof to order items from out of stock of the physical store front retailer.

    摘要翻译： 描述了一种信息系统环境，其中包括促进电子商务和实体店面零售商销售渠道的整合。 在一些实现中，该系统包括与物理店面零售商共同设置的购物者可访问的信息亭和可从实体店面零售商的外部位置访问的电子商务信息服务。 两者都访问从合适的信息服务提供的库存信息。 购物者可访问的信息亭允许其用户访问特定于物理店面零售商的库存信息，而电子商务信息服务允许其用户从实体店面零售商的库存中订购商品。

    Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
    5.
    发明申请
    Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers 有权
    用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂和能量生物标志物的调节

    公开(公告)号：US20060281809A1

    公开(公告)日：2006-12-14

    申请号：US11445582

    申请日：2006-06-01

    申请人： Guy Miller ,  Sidney Hecht

    发明人： Guy Miller ,  Sidney Hecht

    IPC分类号： A61K31/355 ,  A61K31/12 ,  A01N31/14 ,  A61K31/05 ,  C07C50/28 ,  C07C39/10

    CPC分类号： C07C37/07 ,  A61K31/355 ,  C07C39/08 ,  C07C39/19 ,  C07C39/24 ,  C07C39/245 ,  C07C46/00 ,  C07C46/02 ,  C07C46/08 ,  C07C50/02 ,  C07C50/06 ,  C07C50/28 ,  C07C50/24 ,  C07C39/11 ,  C07C39/04

    摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.

    摘要翻译： 公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及 可用于本发明方法的化合物，例如α-生育酚醌。 还公开了可用于治疗其它疾病的方法和化合物。 还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。 还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。

    Assay system for anti-stress agents
    8.
    发明授权
    Assay system for anti-stress agents 失效
    抗压剂测定系统

    公开(公告)号：US06232060B1

    公开(公告)日：2001-05-15

    申请号：US08588893

    申请日：1996-01-19

    申请人： Guy Miller ,  Margaret A. Hirst

    发明人： Guy Miller ,  Margaret A. Hirst

    IPC分类号： C12Q100

    CPC分类号： C12Q1/32

    摘要： Methods and compositions are provided for screening compounds for anti-stress activity. A rat hepatoma-derived cell line is employed, which is particularly responsive to mitochondrial function inhibiting agents, demonstrated by the extracellular release of lactate dehydrogenase and the formation of lactate. Cytoprotectant agents are shown to reverse the lactate dehydrogenase release in the presence of mitochondrial function interfering agents, as a model for the effects of hypoxia on cellular energetic function.

    摘要翻译： 提供了用于筛选抗应激活性化合物的方法和组合物。 使用来自大鼠肝细胞瘤的细胞系，其对线粒体功能抑制剂特别有反应，通过乳酸脱氢酶的细胞外释放和乳酸盐的形成证实。 显示细胞保护剂在线粒体功能干扰剂存在下逆转乳酸脱氢酶释放，作为缺氧对细胞能量功能的影响的模型。

    LIFTING FORCE REGULATED HYDROFOIL
    9.
    发明申请
    LIFTING FORCE REGULATED HYDROFOIL 有权

    公开(公告)号：US20210114692A1

    公开(公告)日：2021-04-22

    申请号：US17050519

    申请日：2019-05-13

    申请人： Guy MILLER

    发明人： Guy MILLER

    IPC分类号： B63B1/28 ,  B63B79/10 ,  B63B1/24

    摘要： The vessels weight is wholly or partially supported by one or more fully or partially submerged hydrofoil(s). The amount of lift provided by said hydrofoil(s) is regulated as a function of that lift itself. External variables such as trim angle and vessel velocity affect total lift, and this system compensates for those variables to provide a regulated lift without the need to directly sense any of the external variables. A typical control system comprises one or more sensory inputs, a method to translate the input into a control output, and an actuator that turns the outputs into actual movements. The only sensory input for this system is the same lifting force that is being regulated. The mechanical arrangement translates that lifting force into movements that produce negative feedback by varying the angle of attack of the hydrofoil, which in turn regulates the lift produced.

    System and method for forecasting portfolio losses at multiple horizons
    10.
    发明授权
    System and method for forecasting portfolio losses at multiple horizons 有权
    多层次投资组合损失预测系统和方法

    公开(公告)号：US07870052B1

    公开(公告)日：2011-01-11

    申请号：US11789318

    申请日：2007-04-24

    申请人： Lisa R. Goldberg ,  Guy Miller ,  Jared Weinstein

    发明人： Lisa R. Goldberg ,  Guy Miller ,  Jared Weinstein

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/06 ,  G06Q40/025

    摘要： A computer system, which may comprise a processor, a memory and a database, may implement a loss surface determining software module that forecasts a portfolio's loss surface. Daily loss histories may be collected from actual data or may be generated using a factor model. A model may generate a sequence of iid high frequency loss innovations that can be temporally aggregated with a Fourier transform. For each portfolio, the loss surface may be forecasted and 95% and 99% value-at-risk and expected shortfall forecasts may be derived for various time horizons.

    摘要翻译： 可以包括处理器，存储器和数据库的计算机系统可以实现预测投资组合的损失表面的损失表面确定软件模块。 每日损失历史可以从实际数据收集，也可以使用因子模型生成。 模型可以产生可以利用傅立叶变换在时间上聚集的iid高频损耗创新的序列。 对于每个投资组合，可以预测损失表面，并可以在不同的时间范围内获得95％和99％的风险价值和预期的短缺预测。