公开(公告)号：US08825564B2

公开(公告)日：2014-09-02

申请号：US13215236

申请日：2011-08-23

申请人： Po-Lei Lee ,  Kuo-Kai Shyu

发明人： Po-Lei Lee ,  Kuo-Kai Shyu

IPC分类号： G06F15/18 ,  A61B5/0482 ,  G06F3/01

CPC分类号： A61B5/0482 ,  G06F3/015

摘要： A visual drive control method with multi-phase encoding includes the following steps. A plurality of flickering sequences are generated by an encoding process according to a reference phase and a plurality of shifting phases divided in time division under at least one phase shift state, then a display unit is driven to display corresponding optical images. An optic nerve of an organism is evoked by the optical images, such that the organism generates a corresponding biological signal. Next, a computation process is performed to a digital biological signal converted from the biological signal to acquire an average captured reference phase and an average captured shifting phase of the digital biological signal. Then, the frequencies and the phase states of the digital biological signal and the flickering sequences are compared to output a corresponding control signal. A visual drive control apparatus with multi-phase encoding is disclosed herein.

摘要翻译： 具有多相编码的视觉驱动控制方法包括以下步骤。 通过根据参考相位的编码处理和在至少一个相移状态下分时划分的多个移相相位产生多个闪烁序列，然后驱动显示单元显示相应的光学图像。 生物体的视神经由光学图像引起，使得生物体产生相应的生物信号。 接下来，对从生物信号转换的数字生物信号进行计算处理，以获取数字生物信号的平均捕获参考相位和平均捕获的移动相位。 然后，比较数字生物信号和闪烁序列的频率和相位状态，输出相应的控制信号。 本文公开了具有多相编码的视觉驱动控制装置。

公开(公告)号：US20130100010A1

公开(公告)日：2013-04-25

申请号：US13357181

申请日：2012-01-24

申请人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

发明人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

IPC分类号： G06F3/01

CPC分类号： G06F3/015

摘要： A control method of a brain computer interface (BCI) with a stepping delay flickering sequence is provided. First, a plurality of different flickering sequence signals are generated by encoding a static flashing segment and a plurality of stepping delay flashing segments divided in different time sequences. Then, a plurality of target images corresponding to the flickering sequence signals are displayed. Thereafter, a response signal generated by an organism evoked by the target images is acquired. Then, signal processing is performed on the response signal by using a mathematic method to distinguish which one of the target images is gazed by the organism. Thereafter, a controlling command corresponding to one of the target images is generated. A control system of a BCI with a stepping delay flickering sequence is also provided herein.

摘要翻译： 提供了具有步进延迟闪烁序列的脑机接口（BCI）的控制方法。 首先，通过对以不同时间序列分割的静态闪烁段和多个步进延迟闪烁段进行编码来生成多个不同的闪烁序列信号。 然后，显示与闪烁序列信号对应的多个目标图像。 此后，获取由目标图像诱发的生物体产生的响应信号。 然后，通过使用数学方法对响应信号进行信号处理，以区分目标图像中哪一个被生物体凝视。 此后，生成与目标图像之一对应的控制命令。 本文还提供了具有步进延迟闪烁序列的BCI控制系统。

公开(公告)号：US20130177661A1

公开(公告)日：2013-07-11

申请号：US13344019

申请日：2012-01-05

申请人： Yi-Lin Chen ,  Hsin-Sheng Tsay ,  Tzong-Der Way ,  Po-Lei Lee ,  Chao-Yuan Yu ,  Chien-Hsu Chen

发明人： Yi-Lin Chen ,  Hsin-Sheng Tsay ,  Tzong-Der Way ,  Po-Lei Lee ,  Chao-Yuan Yu ,  Chien-Hsu Chen

IPC分类号： A61K36/28 ,  A61P29/00

CPC分类号： A61K36/28 ,  A61K2236/30

摘要： Disclosed are a Saussurea involucrate extract, pharmaceutical composition and use thereof for anti-fatigue and anti-aging. In the embodiments of the present invention, a low dose of ethyl acetate fraction of Saussurea involucrate (preferably 30 mg/kg) and Rutin (preferably 30 mg/kg) can inhibit MDA expression level and increase GPx activity. Additionally, both decrease the expression of COX-2, PARP and caspase-3, via downregulation of NF-kappaB, resulting in neuroprotection. Further, syringe feeding of Saussurea involucrate extract is also performed in aging mouse model. In the future, Saussurea involucrate extract of the present invention can be used in neuroprotection, particularly in treatment or prevention of cerebral diseases, nerve diseases, neurodegenerative diseases, chronic neurodegenerative diseases, aging, and fatigue, caused by oxidative injury.

摘要翻译： 公开了一种Saussurea通用提取物，药物组合物及其用于抗疲劳和抗衰老的用途。 在本发明的实施方案中，低剂量的Saussurea比例（优选30mg / kg）和Rutin（优选30mg / kg）的乙酸乙酯级分可以抑制MDA表达水平并增加GPx活性。 另外，通过下调NF-κB，都能降低COX-2，PARP和caspase-3的表达，从而导致神经保护作用。 此外，老化小鼠模型也进行了Saussurea内rate提取物的注射器喂养。 将来，本发明的Saussurea泛酸提取物可用于神经保护，特别是在由氧化损伤引起的脑疾病，神经疾病，神经变性疾病，慢性神经变性疾病，衰老和疲劳的治疗或预防中。

公开(公告)号：US20120249614A1

公开(公告)日：2012-10-04

申请号：US13215236

申请日：2011-08-23

申请人： Po-Lei LEE ,  Kuo-Kai SHYU

发明人： Po-Lei LEE ,  Kuo-Kai SHYU

IPC分类号： G09G5/10

CPC分类号： A61B5/0482 ,  G06F3/015

摘要： A visual drive control method with multi-phase encoding includes the following steps. A plurality of flickering sequences are generated by an encoding process according to a reference phase and a plurality of shifting phases divided in time division under at least one phase shift state, then a display unit is driven to display corresponding optical images. An optic nerve of an organism is evoked by the optical images, such that the organism generates a corresponding biological signal. Next, a computation process is performed to a digital biological signal converted from the biological signal to acquire an average captured reference phase and an average captured shifting phase of the digital biological signal. Then, the frequencies and the phase states of the digital biological signal and the flickering sequences are compared to output a corresponding control signal. A visual drive control apparatus with multi-phase encoding is disclosed herein.

摘要翻译： 具有多相编码的视觉驱动控制方法包括以下步骤。 通过根据参考相位的编码处理和在至少一个相移状态下分时划分的多个移相相位产生多个闪烁序列，然后驱动显示单元显示相应的光学图像。 生物体的视神经由光学图像引起，使得生物体产生相应的生物信号。 接下来，对从生物信号转换的数字生物信号进行计算处理，以获取数字生物信号的平均捕获参考相位和平均捕获的移动相位。 然后，比较数字生物信号和闪烁序列的频率和相位状态，输出相应的控制信号。 本文公开了具有多相编码的视觉驱动控制装置。

公开(公告)号：US20090264788A1

公开(公告)日：2009-10-22

申请号：US12179660

申请日：2008-07-25

申请人： Kuo-kai SHYU ,  Po-lei Lee ,  Ming-huan Lee ,  Chi-hsun Wu ,  Jyun-jle Sie

发明人： Kuo-kai SHYU ,  Po-lei Lee ,  Ming-huan Lee ,  Chi-hsun Wu ,  Jyun-jle Sie

IPC分类号： A61B5/0476 ,  A61G7/015

CPC分类号： A61B5/04842 ,  G06F3/015

摘要： A nursing system of a visual evoked brain wave control device, measuring a brain wave signal induced by the user when gazing at one optical display region, for controlling external devices is designed. The optical flash generating device receives an outer signal to flash the optical display region therein. A brain wave signal measurement device is used to measure a brain wave signal induced by users when gazing at the optical display region. A programmable chip is used to analyze the relation between the brain wave signal and the optical flash generating device, and control a selected option of the optical display region gazed by the users (for example, raising/falling of first, second or third portion of the hospital bed, volume adjustment of radio, channel adjustment, etc.), for improving the independence capability and the life quality of the users.

摘要翻译： 设计了视觉诱发脑电波控制装置的护理系统，用于测量用户在注视一个光学显示区域时引起的用于控制外部设备的脑波信号。 光闪光发生装置接收外部信号以闪光其中的光学显示区域。 脑波信号测量装置用于测量用户在注视光学显示区域时所引起的脑波信号。 使用可编程芯片来分析脑波信号与光闪光发生装置之间的关系，并且控制由用户注视的光学显示区域的选定选项（例如，第一，第二或第三部分的上升/下降 医院病床，无线电量调整，频道调整等），提高用户的独立性和生活质量。

公开(公告)号：US11534620B2

公开(公告)日：2022-12-27

申请号：US16799714

申请日：2020-02-24

申请人： Po-Lei Lee

发明人： Po-Lei Lee

IPC分类号： A61N2/02 ,  A61N2/00 ,  A61N1/40 ,  G01R33/36

摘要： A magnetic stimulation device having planar coil structure is disclosed. It contains a power supply module, a current control module, a plurality of planar coil modules and a plurality of electrical connection modules. In the planar coil module of the present invention, the coil structure has a flat and thin design and can be modularized. Compared with the existing magnetic stimulation devices, the overall structure of the present invention is light, thin, short, convenient to carry and use, and can be installed on clothing or built in a mobile device to provide a convenient magnetic stimulation treatment.

公开(公告)号：US08648800B2

公开(公告)日：2014-02-11

申请号：US13357181

申请日：2012-01-24

申请人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

发明人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

IPC分类号： G09G5/00

CPC分类号： G06F3/015

摘要： A control method of a brain computer interface (BCI) with a stepping delay flickering sequence is provided. First, a plurality of different flickering sequence signals are generated by encoding a static flashing segment and a plurality of stepping delay flashing segments divided in different time sequences. Then, a plurality of target images corresponding to the flickering sequence signals are displayed. Thereafter, a response signal generated by an organism evoked by the target images is acquired. Then, signal processing is performed on the response signal by using a mathematic method to distinguish which one of the target images is gazed by the organism. Thereafter, a controlling command corresponding to one of the target images is generated. A control system of a BCI with a stepping delay flickering sequence is also provided herein.

摘要翻译： 提供了具有步进延迟闪烁序列的脑机接口（BCI）的控制方法。 首先，通过对以不同时间序列分割的静态闪烁段和多个步进延迟闪烁段进行编码来生成多个不同的闪烁序列信号。 然后，显示与闪烁序列信号对应的多个目标图像。 此后，获取由目标图像诱发的生物体产生的响应信号。 然后，通过使用数学方法对响应信号进行信号处理，以区分目标图像中哪一个被生物体凝视。 此后，生成与目标图像之一对应的控制命令。 本文还提供了具有步进延迟闪烁序列的BCI控制系统。

公开(公告)号：US20090264787A1

公开(公告)日：2009-10-22

申请号：US12179639

申请日：2008-07-25

申请人： Po-lei Lee ,  Kuo-kai Shyu ,  Chi-hsun Wu ,  Jyun-jie Sie ,  Ming-huan Lee

发明人： Po-lei Lee ,  Kuo-kai Shyu ,  Chi-hsun Wu ,  Jyun-jie Sie ,  Ming-huan Lee

IPC分类号： A61B5/04

CPC分类号： G06F3/015 ,  A61B5/04842

摘要： In a driving control system actuated by visual evoked brain waves which are induced by a multi-frequency and multi-phase encoder, and a corresponding method configured for analyzing brain wave signals in order to control at least one peripheral equipment, the driving control system includes an optical flash generating device, a brain wave signal measurement device, a signal processing and analyzing device and a control device. The optical flash generating device is configured for generating at least one flash light source by a multi-frequency and multi-phase encoder. The brain wave signal measurement device is configured for measuring a brain wave signal inducing by a user gazing the flash light source. The signal processing and analyzing device is configured for calculating the frequency and the phase of the brain wave by a mathematical method, and analyzing whether the frequency and the phase of the brain wave same to the those of the optical flash generating device. The control device is configured for sending out the frequency and the phase analyzed by the signal processing and analyzing device and same to those of the optical flash generating device so as to control at least one peripheral equipment.

摘要翻译： 在由多频和多相编码器感应的视觉诱发脑波激励的驾驶控制系统中，以及配置用于分析脑波信号以便控制至少一个外围设备的相应方法，所述驾驶控制系统包括 光学闪光发生装置，脑波信号测量装置，信号处理和分析装置以及控制装置。 光闪光发生装置被配置为通过多频和多相编码器产生至少一个闪光光源。 脑波信号测量装置被配置为测量由注视闪光光源的用户引起的脑波信号。 信号处理和分析装置被配置为通过数学方法计算脑波的频率和相位，并且分析脑波的频率和相位是否与光学闪光发生装置的频率和相位相同。 控制装置被配置为将由信号处理和分析装置分析的频率和相位发送到光学闪光发生装置的频率和相位，以便控制至少一个外围设备。

公开(公告)号：US20210260396A1

公开(公告)日：2021-08-26

申请号：US16799714

申请日：2020-02-24

申请人： Po-Lei Lee

发明人： Po-Lei Lee

IPC分类号： A61N2/02 ,  G01R33/36 ,  A61N1/40 ,  A61N2/00

摘要： A magnetic stimulation device having planar coil structure is disclosed. It contains a power supply module, a current control module, a plurality of planar coil modules and a plurality of electrical connection modules. In the planar coil module of the present invention, the coil structure has a flat and thin design and can be modularized. Compared with the existing magnetic stimulation devices, the overall structure of the present invention is light, thin, short, convenient to carry and use, and can be installed on clothing or built in a mobile device to provide a convenient magnetic stimulation treatment.

公开(公告)号：US20120299822A1

公开(公告)日：2012-11-29

申请号：US13561283

申请日：2012-07-30

申请人： Po-lei Lee ,  Kuo-kai Shyu ,  Chi-hsun Wu ,  Jyun-jie Sie ,  Ming-huan Lee

发明人： Po-lei Lee ,  Kuo-kai Shyu ,  Chi-hsun Wu ,  Jyun-jie Sie ,  Ming-huan Lee

IPC分类号： G06F3/01

CPC分类号： G06F3/015 ,  A61B5/04842

摘要： A driving control system actuated by visual evoked brain waves which are induced by a multi-frequency and multi-phase encoder, the driving control system includes an optical flash generating device, a brain wave signal measurement device, a signal processing and analyzing device and a control device. The brain wave signal measurement device is configured for measuring a steady-state visual evoked response (SSVER) signal inducing by a user gazing the flash light source generated by the optical flash generating device. The signal processing and analyzing device is configured for calculating the frequency parameter and the phase parameter of the SSVER signal by a mathematical method, and analyzing whether those parameters are same as the optical flash generating device's parameters so as to generate a judgment result. The control device generates a control command according to the judgment result for controlling at least one of peripheral equipments.

摘要翻译： 由多频多相编码器诱发的视觉诱发脑波激励的驾驶控制系统，驱动控制系统包括光闪发生装置，脑波信号测量装置，信号处理分析装置和 控制装置 脑波信号测量装置被配置为测量由用户注视由光学闪光发生装置产生的闪光光源引起的稳态视觉诱发响应（SSVER）信号。 信号处理和分析装置被配置为通过数学方法计算SSVER信号的频率参数和相位参数，并分析这些参数是否与光学闪光发生装置的参数相同以产生判断结果。 控制装置根据用于控制周边设备中的至少一个的判定结果生成控制命令。