公开(公告)号：US20040213798A1

公开(公告)日：2004-10-28

申请号：US10852740

申请日：2004-05-25

Applicant: PowderJect Vaccines, Inc.

Inventor： Yuh-Fun Maa ,  Lu Zhao ,  Steven J. Prestrelski

IPC: A61K039/00

CPC classification number: A61K9/1694 ,  A61K9/0021

Abstract: A gel-forming free-flowing powder suitable for use as a vaccine is prepared by spray-drying an aqueous suspension that contains an antigen adsorbed to an aluminum salt adjuvant, a saccharide, an amino acid or a salt thereof, and a colloidal substance. Processes for forming these powder compositions are also described, as well as methods of using the compositions in a vaccination procedure.

Abstract translation: 通过喷雾干燥含有吸附在铝盐佐剂，糖类，氨基酸或其盐上的抗原和胶态物质的水性悬浮液来制备适合用作疫苗的凝胶形成自由流动粉末。 还描述了用于形成这些粉末组合物的方法，以及在疫苗接种程序中使用该组合物的方法。

公开(公告)号：US20040109874A1

公开(公告)日：2004-06-10

申请号：US10724727

申请日：2003-12-02

Applicant: PowderJect Vaccines, Inc.

Inventor： Dexiang Chen ,  Sangeeta Bhargava ,  Deborah Fuller

IPC: A61K039/12 ,  A61K039/02

CPC classification number: A61K39/05 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2760/16134

Abstract: Methods for generating an immune response at a mucosal surface are described. Compositions suitable for use in the methods for generating an immune response at a mucosal surface are also described. In addition, methods for treating or preventing a disease caused by the entry of a pathogen into the body of a subject via a mucosal surface are provided.

Abstract translation: 描述了在粘膜表面产生免疫应答的方法。 还描述了适用于在粘膜表面产生免疫应答的方法中的组合物。 此外，提供了用于治疗或预防由病原体经由粘膜表面进入受试者体内引起的疾病的方法。