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    Novel compounds
    2.
    发明申请
    Novel compounds 审中-公开
    新型化合物

    公开(公告)号：US20040241687A1

    公开(公告)日：2004-12-02

    申请号：US10484156

    申请日：2004-06-18

    发明人： Joelle Thonnard ,  Cindy Castado

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  A61K039/02 ,  C07K014/195 ,  C12N001/21

    CPC分类号： C07K14/285 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53

    摘要： The invention provides BASB230 polypeptides and polynucleotides encoding BASB230 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

    摘要翻译： 本发明提供了BASB230多肽和编码BASB230多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。

    Expression system
    3.
    发明申请
    Expression system 有权
    表达系统

    公开(公告)号：US20040235140A1

    公开(公告)日：2004-11-25

    申请号：US10483150

    申请日：2004-06-25

    发明人： Ethel Diane Williamson ,  Leslie William James Baillie ,  Julie Miller

    IPC分类号： A61K039/02 ,  C12N001/21

    CPC分类号： C12N15/75 ,  C07K14/32

    摘要： A recombinant microorganism comprises an asporogenic Bacillus subtilis strain in which a gene encoding a protease enzyme has been downregulated or inactivated. In particular sigma factorspoIIAC is inactivated such that the strain is asporogenic. These strains are particularly useful as expression vehicles for proteins such as protective antigen (PA) of Bacillus anthracis.

    摘要翻译： 重组微生物包含其中编码蛋白酶的基因已被下调或失活的异源枯草芽孢杆菌菌株。 特别是sigma因子pIIAC被灭活，使得菌株是异源的。 这些菌株特别可用作蛋白质的表达载体，例如炭疽芽孢杆菌的保护性抗原（PA）。

    Compositions and methods for tumor-targeted delivery of effector molecules
    4.
    发明申请
    Compositions and methods for tumor-targeted delivery of effector molecules 审中-公开
    用于肿瘤靶向递送效应分子的组合物和方法

    公开(公告)号：US20040229338A1

    公开(公告)日：2004-11-18

    申请号：US10738423

    申请日：2003-12-16

    申请人： Vion Pharmaceuticals, Inc.

    发明人： Ivan C. King

    IPC分类号： A61K048/00 ,  C12N001/21 ,  A61K039/02

    CPC分类号： C12N15/74 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/74 ,  A61K38/00 ,  A61K45/06 ,  A61K48/00 ,  Y02A50/475 ,  A61K2300/00

    摘要： The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the methods of the invention to treat a solid tumor cancer such as a carcinoma, melanoma, lymphoma, or sarcoma. The invention relates to the surprising discovery that effector molecules, which may be toxic when administered systemically to a host, can be delivered locally to tumors by attenuated tumor-targeted bacteria with reduced toxicity to the host. The application also discloses to the delivery of one or more optional effector molecule(s) (termed secondary effector molecules) which may be delivered by the attenuated tumor-targeted bacteria in conjunction with the primary effector molecule(s).

    摘要翻译： 本申请公开了减毒的肿瘤靶向细菌载体用于将一种或多种主效应分子递送至实体瘤的位点的制备和用途。 本发明的主效应分子用于本发明的治疗实体肿瘤癌例如癌，黑素瘤，淋巴瘤或肉瘤的方法中。 本发明涉及令​​人惊奇的发现，当向宿主全身施用时，可能具有毒性的效应分子可以通过对宿主毒性降低的减毒肿瘤靶向细菌局部递送至肿瘤。 本申请还公开了递送一种或多种任选的效应分子（称为次级效应分子），其可以通过减毒的肿瘤靶向细菌与主效应分子结合递送。

    Pharmaceutical use for secreted bacterial effector proteins
    5.
    发明申请
    Pharmaceutical use for secreted bacterial effector proteins 审中-公开
    用于分泌细菌效应蛋白的药物用途

    公开(公告)号：US20040208889A1

    公开(公告)日：2004-10-21

    申请号：US10478516

    申请日：2004-05-26

    发明人： John Mark Sutton ,  Clifford Charles Shone

    IPC分类号： A61K039/02 ,  C07K014/195

    CPC分类号： A61K47/6415 ,  A61K47/65

    摘要： A polypeptide conjugate contains a bacterial injectable effector protein, secreted by a modified pilus or nullneedle-likenull structure comprising a type m or type TV secretion apparatus, and a carrier that targets the conjugate to a target cell. The effector protein is used for a variety of purposes including treatment of neurodegenerative disease, intracellular infection and diseases associated with defects of secretion.

    摘要翻译： 多肽缀合物含有通过修饰的菌毛分泌的细菌注射效应蛋白，或包含m型或TV型分泌装置的“针状”结构，以及将缀合物靶向靶细胞的载体。 效应蛋白用于各种目的，包括治疗神经变性疾病，细胞内感染和与分泌缺陷有关的疾病。

    Crystal structures of streptococcus undecaprenyl pyrophosphate synthase and uses thereof
    6.
    发明申请
    Crystal structures of streptococcus undecaprenyl pyrophosphate synthase and uses thereof 审中-公开
    链球菌十六烷基焦磷酸合成酶的晶体结构及其用途

    公开(公告)号：US20040191271A1

    公开(公告)日：2004-09-30

    申请号：US10815402

    申请日：2004-03-31

    申请人： Pfizer Inc

    发明人： Kimberly F. Fennell ,  Mahmoud N. Mansour ,  Xiayang Qiu

    IPC分类号： A61K039/02 ,  C12N009/16

    CPC分类号： C12N9/1085 ,  C07K2299/00

    摘要： The invention is directed generally to the structure of prenyltransferases, particularly undecaprenyl pyrophosphate synthase, an enzyme important in bacterial cell wall synthesis. The invention relates to the crystal structure of undecaprenyl pyrophosphate synthase from Streptococcus pneumoniae and its interaction with cofactors and ligands. The invention also relates to the structure of ligand and cofactor binding sites of undecaprenyl pyrophosphate synthase.

    摘要翻译： 本发明一般涉及异戊烯转移酶的结构，特别是十一烷基焦磷酸合成酶，这是在细菌细胞壁合成中重要的酶。 本发明涉及来自肺炎链球菌的十一卡非焦磷酸合成酶的晶体结构及其与辅因子和配体的相互作用。 本发明还涉及十一烷基焦磷酸合酶的配体和辅因子结合位点的结构。

    Hybrid vector system for use as a vaccine
    9.
    发明申请
    Hybrid vector system for use as a vaccine 审中-公开
    用作疫苗的杂交载体系统

    公开(公告)号：US20040146486A1

    公开(公告)日：2004-07-29

    申请号：US10350791

    申请日：2003-01-24

    发明人： Juan Sun

    IPC分类号： A61K048/00 ,  A61K039/12 ,  A61K039/02

    CPC分类号： C12N15/85 ,  A61K38/1774 ,  A61K38/2013 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55533 ,  A61K2039/585 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2800/206 ,  Y02A50/412 ,  A61K2300/00

    摘要： A gene delivery system is composed of a yeast hybrid delivery system vector. Two gene-expressing units form the yeast hybrid vaccine delivery system by gene type mating. One unit is engineered to constitutively express a co-stimulator and another can be engineered to express single, fusion or multiple antigens derived from disease causing pathogen. This yeast hybrid vaccine easy delivery system vector is designed to develop novel vaccines. The candidate vaccines include AIDs, cancer, Hepatitis C, Parainfluenza, malaria, autoimmunity and other infectious diseases.

    摘要翻译： 基因递送系统由酵母杂交递送系统载体组成。 两个基因表达单位通过基因型交配形成酵母杂交疫苗递送系统。 一个单位被设计成组成型表达共刺激剂，另一个单元可以被工程化以表达源自疾病引起的病原体的单一，融合或多重抗原。 该酵母杂交疫苗易于递送系统载体旨在开发新型疫苗。 候选疫苗包括AIDs，癌症，丙型肝炎，副流感病毒，疟疾，自身免疫和其他传染病。