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公开(公告)号：US20140193331A1
公开(公告)日：2014-07-10
申请号：US14115752
申请日：2012-05-07
IPC分类号： A61K49/00
CPC分类号： A61K49/0065
摘要： Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.
摘要翻译： 公开了一种非侵入式红外成像方法，包括（a）施用含有发射在短波长红外（SWIR）光谱中的稀土元素的含有红外线发射粒子的组合物，其中颗粒被生物相容性基质 以形成下转换包封的颗粒; 和（b）用红外辐射照射，其中包封的颗粒的激发和发射光谱都在红外区域。 还公开了图像引导生物医学干预的类似方法和药物跟踪和递送。 还公开了一种用于生物医学应用的组合物，其包含含有在短波长红外（SWIR）光谱中发射的稀土元素的红外发射颗粒，其中颗粒用生物相容性基质包封以形成下变频包封的颗粒。
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2.发明授权公开(公告)号：US10016517B2
公开(公告)日：2018-07-10
申请号：US14237974
申请日：2012-08-08
IPC分类号： A61K9/14 , A61K49/00 , G01N33/92 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/16 , A61K9/51 , A61K47/54 , A61K47/64 , A61K47/69
CPC分类号： A61K49/0093 , A61K9/14 , A61K9/141 , A61K9/51 , A61K9/513 , A61K47/542 , A61K47/6425 , A61K47/6907 , A61K49/0082 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/44 , A61L2300/442 , A61L2300/624 , A61L2400/12 , G01N33/92 , C08L71/02
摘要： The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.
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公开(公告)号：US08715718B2
公开(公告)日：2014-05-06
申请号：US12373671
申请日：2007-07-11
CPC分类号： A61K38/38 , A61K9/0024 , A61K9/141 , A61K38/39 , A61K47/643 , A61K47/6929 , B82Y5/00
摘要： Compositions, methods, and kits for repair and production of extracellular matrix are provided. In the broad aspect, the composition comprises a ligand of α5β1 integrin attached to a surface of a nanoparticle composed of a protein, with a proviso that the protein is not fibronectin.
摘要翻译： 提供了用于修复和产生细胞外基质的组合物，方法和试剂盒。 在广泛的方面，组合物包含与由蛋白质组成的纳米颗粒的表面连接的α5和bgr1整联蛋白的配体，条件是蛋白质不是纤连蛋白。
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4.发明申请公开(公告)号：US20100136091A1
公开(公告)日：2010-06-03
申请号：US12373671
申请日：2007-07-11
申请人： Prabhas V. Moghe , Ram Sharma , Marian Pereira
发明人： Prabhas V. Moghe , Ram Sharma , Marian Pereira
CPC分类号： A61K38/38 , A61K9/0024 , A61K9/141 , A61K38/39 , A61K47/643 , A61K47/6929 , B82Y5/00
摘要： Compositions, methods, and kits for repair and production of extracellular matrix are provided. In the broad aspect, the composition comprises a ligand of α5β1 integrin attached to a surface of a nanoparticle composed of a protein, with a proviso that the protein is not fibronectin.
摘要翻译： 提供了用于修复和产生细胞外基质的组合物，方法和试剂盒。 在广泛的方面，组合物包含与由蛋白质组成的纳米颗粒的表面连接的α5和bgr1整联蛋白的配体，条件是蛋白质不是纤连蛋白。
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公开(公告)号：US10286088B2
公开(公告)日：2019-05-14
申请号：US14115752
申请日：2012-05-07
IPC分类号： A61K49/00
摘要： Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.
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6.发明申请BIOACTIVE AMPHIPHILIC POLYMER STABILIZED NANOPARTICLES WITH ENHANCED STABILITY AND ACTIVITY 有权具有增强稳定性和活性的生物活性聚合物稳定纳米颗粒公开(公告)号：US20140328763A1
公开(公告)日：2014-11-06
申请号：US14237974
申请日：2012-08-08
CPC分类号： A61K49/0093 , A61K9/14 , A61K9/141 , A61K9/51 , A61K9/513 , A61K47/542 , A61K47/6425 , A61K47/6907 , A61K49/0082 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/44 , A61L2300/442 , A61L2300/624 , A61L2400/12 , G01N33/92 , C08L71/02
摘要： The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.
摘要翻译： 本发明涉及纳米颗粒组合物和使用纳米颗粒靶向A类和B类清道夫受体的心血管疾病的治疗。 本发明进一步涉及检测表达清道夫受体，检测动脉粥样硬化病变和将生物活性两亲性大分子靶向表达清道夫受体的细胞的细胞的方法。
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