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公开(公告)号：US20090155368A1
公开(公告)日：2009-06-18
申请号：US12314554
申请日：2008-12-12
申请人： Stephen Randall Holmes-Farley , David J. Harris , Steven C. Polomoscanik , Adnan Salameh , Bruce Shutts , Richard Silva , Pradeep K. Dhal , Lynne Sole
发明人： Stephen Randall Holmes-Farley , David J. Harris , Steven C. Polomoscanik , Adnan Salameh , Bruce Shutts , Richard Silva , Pradeep K. Dhal , Lynne Sole
IPC分类号： A61K9/14 , A61K31/785 , A61P1/00
CPC分类号： A61K31/785 , A61K9/146 , A61K9/16 , A61K9/1688 , A61K9/20 , A61K9/2031 , A61K9/2077 , A61K9/2095 , A61K9/282 , A61K9/284 , A61K9/2853 , B01J41/14 , Y10T428/2982
摘要： The present invention relates to crosslinked polyamine particles and/or pharmaceutical compositions comprising, at least in part, crosslinked polyamine particles and aggregates of such particles (including cured aggregates of crosslinked polyamine particles). The compositions may be in the form of tablets comprising, for example, particles larger than 500 μm, and used for treating patients, for example, patients with hyperphosphatemia.
摘要翻译： 本发明涉及交联的多胺颗粒和/或药物组合物，其至少部分地包含交联的多胺颗粒和这种颗粒的聚集体（包括交联的聚胺颗粒的固化聚集体）。 组合物可以是包含例如大于500μm的颗粒的片剂的形式，并且用于治疗患者，例如高磷酸盐血症的患者。
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公开(公告)号：US20110142952A1
公开(公告)日：2011-06-16
申请号：US13000114
申请日：2009-06-17
申请人： David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
发明人： David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
IPC分类号： A61K9/16 , A61K31/785 , A61K31/132 , C08G73/02 , C07C217/42 , B32B5/16
CPC分类号： A61K9/1641 , Y10T428/2982
摘要： This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol. % of the particles have a particle size greater than 500 μm.
摘要翻译： 本发明涉及用于结合化合物或离子的交联的含胺聚合物，更具体地涉及用于结合包含交联的含胺聚合物的化合物或离子的药学上可接受的组合物。 药学上可接受的组合物包括例如交联的多胺颗粒或其药学上可接受的盐，其具有大于10体积％ 颗粒的％具有大于500μm的粒度。
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公开(公告)号：US08425887B2
公开(公告)日：2013-04-23
申请号：US12311362
申请日：2007-09-26
申请人： Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
发明人： Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
IPC分类号： A61K8/72
CPC分类号： C08G69/40 , A61K8/72 , A61K31/785 , C07C235/08 , C07C237/10 , C08G83/003 , C08L101/00
摘要： Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
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公开(公告)号：US20100069500A1
公开(公告)日：2010-03-18
申请号：US12311362
申请日：2007-09-26
申请人： Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
发明人： Pradeep K. Dhal , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Vitaly Nivorozhkin , Bruce Shutts
CPC分类号： C08G69/40 , A61K8/72 , A61K31/785 , C07C235/08 , C07C237/10 , C08G83/003 , C08L101/00
摘要： Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
摘要翻译： 酰胺化合物，酰胺聚合物，包括酰胺化合物和酰胺聚合物的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，酰胺化合物和酰胺聚合物可以包括衍生自酰胺多元醇和有机多酸或酯的核。
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公开(公告)号：US20100196305A1
公开(公告)日：2010-08-05
申请号：US12449974
申请日：2008-03-05
IPC分类号： A61K31/795 , A61P3/00
CPC分类号： C08G75/20 , C08G65/24 , C08G73/0253
摘要： Sulfone-containing copolymers and copolymer networks and compositions including sulfone-containing copolymers and copolymer networks may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, sulfone-containing copolymers and copolymer networks may be derived from a multi-amine monomer and a multifunctional sulfonyl-containing monomer comprising two or more amine-reactive groups.
摘要翻译： 包含砜的共聚物和共聚物网络以及包含含砜共聚物和共聚物网络的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，含砜共聚物和共聚物网络可以衍生自多胺单体和包含两个或更多个胺反应性基团的多官能磺酰基单体。
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公开(公告)号：US20100129309A1
公开(公告)日：2010-05-27
申请号：US12449729
申请日：2008-02-20
IPC分类号： A61K31/785 , A61P13/12
CPC分类号： A61K31/785 , A61K31/795 , C08G73/0206
摘要： A pharmaceutical composition for treating hyperphosphatemia can include polymers derived from multi-amine monomers and multifunctional monomers, where the multifunctional monomer includes more than one electrophilic group.
摘要翻译： 用于治疗高磷酸盐血症的药物组合物可以包括衍生自多胺单体和多官能单体的聚合物，其中多官能单体包括多于一个亲电子基团。
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公开(公告)号：US20100166696A1
公开(公告)日：2010-07-01
申请号：US12451060
申请日：2008-04-25
IPC分类号： A61K31/765 , A61P13/12
CPC分类号： A61K31/785 , A61K31/131 , A61K31/74 , A61K2300/00
摘要： Amide compounds, amide polymers and compositions, including amide compounds and amide polymers, may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, the amide polymers may be amido-amine dendrimers that may be formed via a series of iterative reactions.
摘要翻译： 酰胺化合物，酰胺聚合物和包括酰胺化合物和酰胺聚合物的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，酰胺聚合物可以是可以通过一系列迭代反应形成的酰胺 - 胺树枝状大分子。
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公开(公告)号：US20100234309A1
公开(公告)日：2010-09-16
申请号：US12310514
申请日：2007-08-31
申请人： Christopher Cooper , Pradeep K. Dhal , Rayomand H. Gimi , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Edward Lee
发明人： Christopher Cooper , Pradeep K. Dhal , Rayomand H. Gimi , David J. Harris , Stephen Randall Holmes-Farley , Chad C. Huval , Edward Lee
IPC分类号： A61K31/7004 , A61P7/00 , A61P39/00 , A61K31/13
CPC分类号： C07C217/08 , A61K31/785
摘要： Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
摘要翻译： 胺化合物，胺聚合物，交联胺聚合物和包含它们的药物组合物可以包括可以被胺基取代的含多羟基的核心，并且可以用于治疗高磷酸盐血症或从动物（包括人）的胃肠道中除去离子。
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公开(公告)号：US08163799B2
公开(公告)日：2012-04-24
申请号：US12448222
申请日：2007-12-10
IPC分类号： A61K31/221 , A61K31/132 , A61P13/22
CPC分类号： A61K31/785 , A61K31/165 , A61K31/23
摘要： Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
摘要翻译： 化合物，聚合物，交联聚合物和包含其的药物组合物可衍生自具有两个或多个胺反应性基团的多胺单体和多官能单体。 这些化合物，聚合物，交联聚合物和组合物可用于治疗高磷血症或从动物（包括人）的胃肠道中除去离子。
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公开(公告)号：US20100254935A1
公开(公告)日：2010-10-07
申请号：US12656945
申请日：2010-02-19
IPC分类号： A61K31/785 , A61P39/00
CPC分类号： A61K31/785 , C08G73/02 , C08G73/0206
摘要： Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.
摘要翻译： 公开了一种聚合物或其生理上可接受的盐。 聚合物包含聚合的多官能胺单体。 胺单体包含至少两个胺基团和至少两个通过-CH 2 CH 2 - 基团连接的无环氮原子，条件是胺单体不是乙二胺或二亚乙基三胺。 所公开的聚合物可用于结合需要这种治疗的受试者中的阴离子。
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