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公开(公告)号:US20080025875A1
公开(公告)日:2008-01-31
申请号:US11664339
申请日:2005-09-29
申请人: Charles Martin , Zuzanna Siwy , Punit Kohli , Lacramioara Trofin , C. Harrell
发明人: Charles Martin , Zuzanna Siwy , Punit Kohli , Lacramioara Trofin , C. Harrell
CPC分类号: B01D69/02 , B01D67/0032 , B01D67/0034 , B01D67/0062 , B01D67/0069 , B01D67/0093 , B01D69/141 , B01D71/022 , B01D71/027 , B01D71/48 , B01D71/50 , B01D71/64 , B01D2325/021 , B01J20/28033 , B01J20/2808 , B01J20/28097 , B01J20/3242 , B82Y15/00 , G01N30/7233 , G01N33/48721 , G01N33/5302 , G01N2030/027
摘要: The subject invention provides novel and efficacious systems and methods for particle, chemical, and/or biocompound sensing. In one embodiment, the system of the invention comprises a sensing device that includes a membrane containing at least one nanochannel that spans all or substantially all of the thickness of the membrane. The nanochannel(s) of the invention can be functionalized to enhance target analyte detection and quantification. In one embodiment, the nanochannel is conically shaped and includes a molecular recognition agent for a target analyte. In certain operations, the sensing systems of the invention quantitatively and qualitatively detect biochemical/biomedical species and biomacromolecules, such as proteins, DNA, cells, spores and viruses, with a high degree of sensitivity and specificity.
摘要翻译: 本发明提供了用于颗粒,化学和/或生物复合物感测的新颖有效的系统和方法。 在一个实施例中,本发明的系统包括感测装置,该感测装置包括包含至少一个跨越膜的全部或基本上全部的纳米通道的膜。 本发明的纳米通道可以被功能化以增强目标分析物的检测和定量。 在一个实施方案中,纳米通道是锥形的并且包括用于靶分析物的分子识别剂。 在某些操作中,本发明的感测系统以高灵敏度和特异性定量和定性地检测生物化学/生物医学物种和生物大分子,如蛋白质,DNA,细胞,孢子和病毒。
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公开(公告)号:US06528603B1
公开(公告)日:2003-03-04
申请号:US09482492
申请日:2000-01-13
申请人: Gary J. Blanchard , Punit Kohli
发明人: Gary J. Blanchard , Punit Kohli
IPC分类号: C08F2240
CPC分类号: C08F222/40 , C08F230/02
摘要: The present invention provides novel organic copolymers comprising alternating functional groups, wherein one functional group is phosphonate. In one embodiment, the copolymers comprise alternating phosphonate and N-substituted succinimide functional groups. In another embodiment, the copolymers are synthesized from maleimide and vinyl ether monomers, wherein the vinyl ether monomer possesses a pendant phosphonate functionality and the maleimide monomer is an N-substituted maleimide. Methods of synthesizing thin films with the novel organic copolymers, as well as chemical precipitation methods using the novel organic copolymers, are also provided.
摘要翻译: 本发明提供了包含交替官能团的新型有机共聚物,其中一个官能团是膦酸酯。 在一个实施方案中,共聚物包含交替的膦酸酯和N-取代的琥珀酰亚胺官能团。 在另一个实施方案中,共聚物由马来酰亚胺和乙烯基醚单体合成,其中乙烯基醚单体具有侧链膦酸酯官能团,马来酰亚胺单体是N-取代的马来酰亚胺。 还提供了使用新型有机共聚物合成薄膜的方法以及使用新型有机共聚物的化学沉淀方法。
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