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公开(公告)号：US10208328B2
公开(公告)日：2019-02-19
申请号：US14883101
申请日：2015-10-14
Applicant: Quanta Matrix Co., Ltd.
Inventor： Yong-Gyun Jung , Eun-Geun Kim , Jung Heon Yoo , Sunghoon Kwon , Jungil Choi , Hee Chan Kim , Jung Chan Lee , Eui Jong Kim , Sang Hoon Song , Sei Ick Joo , Ji Soo Lee
IPC: C12Q1/18
Abstract: Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
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Patent Agency Ranking
2.发明申请RAPID ANTIMICROBIAL SUSCEPTIBILITY TEST, BASED ON AN ANALYSIS OF CHANGES IN MORPHOLOGY AND GROWTH PATTERN OF A MICROBIAL CELL UNDER DIFFERENT CONCENTRATIONS OF VARIOUS ANTIMICROBIAL AGENTS, AND AUTOMATED CELL IMAGE ANALYSIS SYSTEM THEREFOR 审中-公开基于各种抗微生物剂不同浓度下微生物细胞形态和生长模式变化的分析及其自动化细胞图像分析系统的快速抗微生物耐受性测试公开(公告)号：US20160102334A1
公开(公告)日：2016-04-14
申请号：US14883101
申请日：2015-10-14
Applicant: Quanta Matrix Co., Ltd. , Seoul National University R&DB Foundation , Seoul National University Hospital
Inventor： Yong-Gyun Jung , Eun-Geun Kim , Jung Heon Yoo , Sunghoon Kwon , Jungil Choi , Hee Chan Kim , Jung Chan Lee , Eui Jong Kim , Sang Hoon Song , Sei Ick Joo , Ji Soo Lee
IPC: C12Q1/18
CPC classification number: C12Q1/18 , G06T2207/30024
Abstract: Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
Abstract translation: 提供了基于不同浓度的各种抗微生物剂下微生物细胞的形态和生长模式变化的分析以及其自动化细胞图像分析系统的快速抗微生物敏感性试验。 基于不同浓度的各种抗菌剂对微生物细胞的形态和生长模式的变化进行分析，快速进行抗微生物敏感性试验，这使得可以获得高可靠性的测试结果比标准更快六至七倍 临床和实验室标准研究所（CLSI）推荐的方法。
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公开(公告)号：US10676776B2
公开(公告)日：2020-06-09
申请号：US14816071
申请日：2015-08-03
Applicant: SNU R & DB FOUNDATION , QUANTA MATRIX CO., LTD.
Inventor： Sunghoon Kwon , Yong-Gyun Jung , Jung Il Choi , Hun Jong Na
Abstract: A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results.
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公开(公告)号：US10253348B2
公开(公告)日：2019-04-09
申请号：US14413008
申请日：2013-07-04
Applicant: QUANTA MATRIX CO,. LTD.
Inventor： Yong Gyun Jung
Abstract: Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures.
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公开(公告)号：US20150361477A1
公开(公告)日：2015-12-17
申请号：US14413008
申请日：2013-07-04
Applicant: QUANTA MATRIX CO., LTD.
Inventor： Yong Gyun JUNG
CPC classification number: C12Q1/24 , C12M25/00 , C12M33/02 , C12N11/02 , C12N11/06 , C12N11/08 , C12N11/14
Abstract: Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures.
Abstract translation: 提供了使用微结构捕获和释放微生物的方法。 该方法包括提供涂覆有微生物附着/分离的蛋白质的微结构，将微结构与含有有助于微生物附着的物质的溶液混合在含有微生物的溶液中以制备混合溶液，搅拌混合溶液以将微生物附着于 微结构，从混合溶液中分离微生物附着的微结构; 并将微结构暴露于其中辅助附着微生物的物质以低浓度存在的环境，以将微生物从微结构中分离出来。
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公开(公告)号：US10894941B2
公开(公告)日：2021-01-19
申请号：US14888530
申请日：2014-05-02
Inventor： Yong Gyun Jung , Eun Geun Kim , Sung hoon Kwon , Jung Il Choi
Abstract: A microfluidic multi-well-based cell culture testing device is provided. The multi-well-based cell culture testing device has an array structure of a plurality of aligned microfluidic well units. Each of the microfluidic well units comprises an inlet through which a first fluid enters, an accommodation compartment adapted to accommodate a second fluid therein, a microfluidic channel through which the first fluid flows, and an air outlet adapted to facilitate the entering of the first fluid.
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