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公开(公告)号：US10959938B2
公开(公告)日：2021-03-30
申请号：US14367408
申请日：2012-12-21
IPC分类号： A61K31/185 , A61K9/00 , A61K31/4178 , A61K31/567 , A61P9/12 , A61K31/4184 , A61K31/255 , A61K31/4704 , A61K38/00 , A61K31/403 , A61K31/41 , A61K38/05 , A61K31/401 , A61K45/06 , A61K35/74
摘要： The present invention relates to a pharmaceutical composition comprising, in at least one pharmaceutically acceptable support or vehicle, a combination of (3S,3S′)4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) or a pharmaceutically acceptable salt or solvate thereof and a second active ingredient selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type I antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.
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2.发明授权Crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine 有权（3S，3S'）4,4'-二硫代二烷基双（3-氨基丁烷-1-磺酸）与L-赖氨酸的结晶相公开(公告)号：US09487477B2
公开(公告)日：2016-11-08
申请号：US15012625
申请日：2016-02-01
申请人： Quantum Genomics
IPC分类号： C07C323/66 , C07C319/28 , C07C227/42
CPC分类号： C07C319/28 , A61K31/145 , A61K47/183 , C07B2200/13 , C07C227/42 , C07C229/26 , C07C323/66
摘要： The present invention relates to a new crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.
摘要翻译： 本发明涉及具有L-赖氨酸的（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）的新结晶相及其用途，特别是在制药工业中，以及 其制备方法。 本发明还涉及含有（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）与L-赖氨酸的至少一个结晶相和治疗或预防用途的药物组合物 的这种结晶相和包含它们的组合物。
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3.发明申请COMBINATION OF (3S,3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIC ACID) AND A SECOND ANTIHYPERTENSIVE AGENT 审中-公开（3S，3S'）4,4'-二磺酰基亚氨基（3-氨基哌嗪-1-磺酸）与第二抗真菌剂的组合公开(公告)号：US20150320703A1
公开(公告)日：2015-11-12
申请号：US14367408
申请日：2012-12-21
IPC分类号： A61K31/185 , A61K38/00 , A61K9/00 , A61K38/05 , A61K31/41
摘要： The present invention relates to a pharmaceutical composition comprising, in at least one pharmaceutically acceptable support or vehicle, a combination of (3S,3S′)4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) or a pharmaceutically acceptable salt or solvate thereof and a second active ingredient selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type I antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.
摘要翻译： 本发明涉及一种药物组合物，其在至少一种药学上可接受的载体或媒介物中包含（3S，3S'）4,4'-二硫代二基双（3-氨基丁烷-1-磺酸）或其药学上可接受的盐或 其溶剂合物和选自血管紧张素I转换酶抑制剂和血管紧张素II受体I型拮抗剂的第二活性成分。 所述组合物特别可用于治疗高血压和相关疾病和病症。
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公开(公告)号：US20210309678A1
公开(公告)日：2021-10-07
申请号：US17288516
申请日：2019-10-25
申请人： QUANTUM GENOMICS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE
IPC分类号： C07F9/58 , C07F9/30 , C07F9/6539 , C07F9/653
摘要： The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
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公开(公告)号：US20210309677A1
公开(公告)日：2021-10-07
申请号：US17288517
申请日：2019-10-25
申请人： QUANTUM GENOMICS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE
摘要： The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
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公开(公告)号：US20230233492A1
公开(公告)日：2023-07-27
申请号：US17922982
申请日：2021-05-05
申请人： QUANTUM GENOMICS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE
IPC分类号： A61K31/145 , A61K31/549 , A61K38/55 , A61K31/401 , A61K31/41 , A61P9/12
CPC分类号： A61K31/145 , A61K31/549 , A61K38/556 , A61K31/401 , A61K31/41 , A61P9/12
摘要： The present invention relates to a pharmaceutical combination comprising (i) firibastat, (ii) a diuretic and (iii) a blocker of the systemic renin-angiotensin system selected from the group consisting of angiotensin I converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 (AT1R) antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.
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7.发明授权Crystalline phase of (3S.3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine 有权（3S.3S'）4,4'-二硫代二烷基双（3-氨基丁烷-1-磺酸）与L-赖氨酸的结晶相公开(公告)号：US09278921B2
公开(公告)日：2016-03-08
申请号：US14437343
申请日：2013-10-22
申请人： Quantum Genomics
IPC分类号： C07C323/66 , C07C229/26 , A61K31/145 , A61K47/18
CPC分类号： C07C319/28 , A61K31/145 , A61K47/183 , C07B2200/13 , C07C227/42 , C07C229/26 , C07C323/66
摘要： The present invention relates to a new crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.
摘要翻译： 本发明涉及具有L-赖氨酸的（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）的新结晶相及其用途，特别是在制药工业中，以及 其制备方法。 本发明还涉及含有（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）与L-赖氨酸的至少一个结晶相和治疗或预防用途的药物组合物 的这种结晶相和包含它们的组合物。
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8.发明授权公开(公告)号：US11345658B2
公开(公告)日：2022-05-31
申请号：US17437862
申请日：2020-03-11
申请人： QUANTUM GENOMICS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE
发明人： Fabrice Balavoine , Delphine Compere , Mathilde Keck , Yannick Marc , Catherine Llorens-Cortes , Solène E. Boitard
IPC分类号： C07C323/58 , A61P9/12 , A61K31/10 , A61K31/198
摘要： The present invention relates to compounds, to compositions comprising the same, to methods for preparing the compounds, and the use of these compounds in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
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公开(公告)号：US11192907B2
公开(公告)日：2021-12-07
申请号：US17288516
申请日：2019-10-25
申请人： QUANTUM GENOMICS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE
IPC分类号： C07F9/58 , C07F9/30 , C07F9/653 , C07F9/6539
摘要： The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
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10.发明申请CRYSTALLINE PHASE OF (3S,3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIC ACID) WITH L-LYSINE 审中-公开（3S，3S'）四氢呋喃（3-AMINOBUTANE 1-SULFONIC ACID）与L-赖氨酸的晶相公开(公告)号：US20160221940A1
公开(公告)日：2016-08-04
申请号：US15012625
申请日：2016-02-01
申请人： Quantum Genomics
IPC分类号： C07C319/28 , C07C227/42
CPC分类号： C07C319/28 , A61K31/145 , A61K47/183 , C07B2200/13 , C07C227/42 , C07C229/26 , C07C323/66
摘要： The present invention relates to a new crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.
摘要翻译： 本发明涉及具有L-赖氨酸的（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）的新结晶相及其用途，特别是在制药工业中，以及 其制备方法。 本发明还涉及含有（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）与L-赖氨酸的至少一个结晶相和治疗或预防用途的药物组合物 的这种结晶相和包含它们的组合物。
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