公开(公告)号：US20250079018A1

公开(公告)日：2025-03-06

申请号：US18947247

申请日：2024-11-14

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. ,  RAMBAM HEALTH CORPORATION

Inventor： Amir Landesberg ,  Yakov Tsibulsky ,  Shmuel Rispler

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/08 ,  A61B5/11 ,  A61B5/113 ,  G16H10/60 ,  G16H40/63 ,  G16H50/20

Abstract: A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.

公开(公告)号：US20170076045A1

公开(公告)日：2017-03-16

申请号：US15121779

申请日：2015-02-27

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. ,  RAMBAM HEALTH CORPORATION

Inventor： Amir LANDESBERG ,  Yaakov ZIBOLI ,  Shmuel RISPLER

IPC: G06F19/00 ,  A61B5/08

CPC classification number: G16H50/30 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/0816 ,  A61B5/1118 ,  A61B5/113 ,  A61B5/4866 ,  A61B5/6823 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7282 ,  A61B2505/07 ,  A61B2562/0219 ,  G16H10/60 ,  G16H40/63 ,  G16H50/20

Abstract: A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.

Abstract translation: 一种方法，包括基于感测到的本地加速度传感器的信息来感测本地加速度或传感器位置的改变，包括姿态和位移，以及安装在患者的胸部或腹部上的局部加速度传感器，以及计算多相运动的能量，并分类 通过计算过多能量指数（EEi）来比较心脏代偿失调的严重程度，该能量指数将多相运动中出现的过度能量与基本呼吸频率下的吸气所需的能量进行比较。

公开(公告)号：US20160008130A1

公开(公告)日：2016-01-14

申请号：US14770842

申请日：2014-02-27

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMBAM HEALTH CORPORATION

Inventor： Tal HASIN

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2418 ,  A61F2/2454 ,  A61F2/2466 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/006

Abstract: An adjustable implantable annuloplasty apparatus suited for post-implantation adjustments according to changing needs of the patient. The apparatus comprises a ring shaped main body, and a designated adjustment section extending from the main body. The main body and designated adjustment section of a deployed apparatus are fully contained within a 5 cm diameter. Optionally, the apparatus is mechanically adjusted in a minimally invasive procedure, for example by engaging the designated adjustment section using a balloon catheter. Optionally, the apparatus is adjusted at least one month post implantation.

Abstract translation: 一种可调节植入式瓣膜成形术装置，适合于根据患者不断变化的需要进行植入后调整。 该装置包括环形主体和从主体延伸的指定的调节部。 展开装置的主体和指定的调节部分完全包含在5厘米直径内。 可选地，该装置以微创程序机械地调节，例如通过使用球囊导管接合指定的调整部分。 任选地，在植入后至少一个月调整该装置。

公开(公告)号：US20160000415A1

公开(公告)日：2016-01-07

申请号：US14772364

申请日：2014-03-04

Applicant: RAMBAM HEALTH CORPORATION

Inventor： Ziv BELSKY ,  Gilad HIZKIYAHU ,  Jesse LACHTER

IPC: A61B10/04 ,  A61B10/02

Abstract: An apparatus, device and method are provided for endoscopically extracting multiple tissue samples from multiple locations without needing to completely retract the apparatus or device from the target tissue in the process. In some embodiments the device includes a sheath for delivering the device through a body lumen wall, an outer needle, an inner needle extendable from and retractable into the outer needle, the inner needle having a rotational feature to enable sequential entry of the inner needle at multiple angles relative to the outer needle; and a rotational control mechanism for controlling rotation of the inner needle thereby enabling tissue extraction from multiple locations in a target tissue, without sequentially exiting the body lumen wall.

Abstract translation: 提供了一种装置，装置和方法，用于内窥镜地从多个位置抽取多个组织样本，而不需要在该过程中将目标组织完全缩回装置或装置。 在一些实施例中，所述装置包括用于通过体腔壁，外针，从所述外针伸出并可缩回到所述外针中的内针来输送所述装置的护套，所述内针具有旋转特征以使所述内针能够顺序进入 相对于外针的多个角度; 以及旋转控制机构，用于控制内针的旋转，从而使得能够组织从目标组织中的多个位置提取，而不必顺序地离开体腔壁。

公开(公告)号：US20160175364A1

公开(公告)日：2016-06-23

申请号：US14908249

申请日：2014-07-28

Applicant: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES ,  RAMBAM HEALTH CORPORATION

Inventor： Anat AHARON ,  Lior GEPSTEIN ,  Benjamin BRENNER

IPC: A61K35/50 ,  A61K38/18 ,  A61K38/19 ,  A61K39/00

CPC classification number: A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/19 ,  A61K38/20 ,  A61K39/0008 ,  C12N5/0605 ,  A61K2300/00

Abstract: The invention relates to pharmaceutical compositions comprising trophoblast derived microparticles for the treatment of damaged tissue, including, ischemic tissue and wounds.

Abstract translation: 本发明涉及包含滋养层衍生的微粒用于治疗受损组织，包括缺血组织和伤口的药物组合物。

公开(公告)号：US20160151124A1

公开(公告)日：2016-06-02

申请号：US14904198

申请日：2014-07-10

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  RAMBAM HEALTH CORPORATION

Inventor： Abraham J. DOMB ,  Zahava GALLIMIDI

IPC: A61B90/00 ,  A61K49/18 ,  A61K49/22 ,  A61K49/04

CPC classification number: A61B90/39 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3995 ,  A61K9/0024 ,  A61K47/34 ,  A61K49/04 ,  A61K49/1803 ,  A61K49/226 ,  A61L31/06 ,  A61L31/148 ,  A61L31/18 ,  C08L67/04

Abstract: The invention generally provides implants comprising polymers and contrast agents for marking and monitoring medical conditions.

Abstract translation: 本发明通常提供包含用于标记和监测医学状况的聚合物和造影剂的植入物。