公开(公告)号：US20240234070A1

公开(公告)日：2024-07-11

申请号：US17925606

申请日：2022-11-03

Applicant: REMEDI CO., LTD

Inventor： Re Na LEE ,  Sung Ho CHO ,  Byoung Tae JANG

IPC: H01J9/02 ,  H01J35/08

CPC classification number: H01J9/02 ,  H01J35/112

Abstract: The present inventive concept provides a method for manufacturing a filament including the steps of inserting and bonding an electrode having a desired length into a through-hole of a plate-shaped base to form a first part; bonding a wire having a desired length to one surface of a plate-shaped disc to form a second part; and bonding the electrode of the first part and the wire of the second part to form a filament, a filament manufactured by said method, and an X-ray tube having said filament.

公开(公告)号：US20240237182A1

公开(公告)日：2024-07-11

申请号：US17925603

申请日：2022-11-03

Applicant: REMEDI CO., LTD

Inventor： Re Na LEE ,  Young Hwan KIM ,  Sung Ho CHO ,  Hyun Jun KIM

IPC: H05G1/32 ,  H05G1/10 ,  H05G1/26 ,  H05G1/56

CPC classification number: H05G1/32 ,  H05G1/10 ,  H05G1/265 ,  H05G1/56

Abstract: The present inventive concept provides a voltage generating apparatus for X-rays including a console that receives an X-ray irradiation signal to generate a control signal and detects the X-ray irradiation signal to generate a first detection signal, a pulse control unit that receives the control signal and the first detection signal from the console to generate a second detection signal and generates a pulse signal according to the control signal and the second detection signal, and a high voltage generating unit that generates a high voltage according to the pulse signal from the pulse control unit, and an X-ray generating apparatus having the same.

公开(公告)号：US20240207162A1

公开(公告)日：2024-06-27

申请号：US18288824

申请日：2022-05-03

Applicant: REMEDI CO., LTD.

Inventor： Chanho PARK ,  Seongmin CHO

IPC: A61K8/64 ,  C07K7/06 ,  C07K7/08 ,  C12N15/87

CPC classification number: A61K8/64 ,  C07K7/06 ,  C07K7/08 ,  C12N15/87 ,  C07K2319/09 ,  C07K2319/10

Abstract: The present invention relates to a human ADARB2-derived cell-penetrating peptide and a cargo-molecule delivery system using the same, and provides a method for delivering cargo molecules into a cell, the method comprising a step for bringing a cargo-molecule transduction domain including the human ADARB2-derived RMAD1 or a variant thereof and a recombinant cargo molecule fused with the cargo molecule transduction domain into contact with cells. The cargo molecule transduction domain of the present invention not only can introduce cargo molecules into cells at a higher efficiency than existing cell-penetrating peptides, but is a polypeptide sequence derived from human proteins, and thus also has no risk of causing immune response problems. Thus the cargo molecule transduction domain is useful for delivering various polymer materials into human cells.

公开(公告)号：US20240252660A1

公开(公告)日：2024-08-01

申请号：US18290570

申请日：2022-05-24

Applicant: REMEDI CO., LTD.

Inventor： Chanho PARK ,  Seongmin CHO

IPC: A61K47/64 ,  A61K8/64 ,  A61K39/385 ,  A61K48/00

CPC classification number: A61K47/64 ,  A61K8/64 ,  A61K39/385 ,  A61K48/0033

Abstract: The present invention relates to a human MRPL15-derived cell-penetrating peptide and a cargo-molecule delivery system using the same, and provides a method for delivering cargo molecules into a cell, the method comprising a step for bringing a cargo-molecule transduction domain including the human MRPL15-derived RMMR1 or a variant resulting from substitution or deletion thereof and a recombinant cargo molecule fused with the cargo molecule transduction domain into contact with cells, wherein the cargo molecule transduction domain of the present invention not only can introduce cargo molecules into cells at a higher efficiency than existing cell-penetrating peptides, but is a polypeptide sequence derived from human proteins, and thus also has no risk of causing immune response problems. Thus the cargo molecule transduction domain is useful for delivering various polymer materials into human cells.

公开(公告)号：US20240224407A1

公开(公告)日：2024-07-04

申请号：US17925608

申请日：2022-11-03

Applicant: REMEDI CO., LTD

Inventor： Re Na LEE ,  Young Hwan KIM ,  Sung Ho CHO ,  Hyun Jun KIM

IPC: H05G1/26 ,  H05G1/32

CPC classification number: H05G1/265 ,  H05G1/32

Abstract: According to the present inventive concept, there is provided an X-ray generating apparatus including a voltage generating apparatus that generates a pulse signal according to an X-ray irradiation signal and generates a predetermined voltage according to the pulse signal, and an X-ray tube that generates X-rays according to the voltage from the voltage generating apparatus, wherein the voltage generating apparatus detects arc discharge by detecting a current of the X-ray tube.