专利检索 ap:"Rachel Elizabeth Anne Stead" 第 1 页

1.

发明授权
N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效

公开(公告)号：US07893090B2

公开(公告)日：2011-02-22

申请号：US11928072

申请日：2007-10-30

申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/4525 , C07D401/06

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

2.

发明申请
N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS 失效

公开(公告)号：US20090012083A1

公开(公告)日：2009-01-08

申请号：US11926398

申请日：2007-10-29

申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp

发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/454 , A61P3/04 , C07D417/14 , C07D405/14 , C07D413/14 , C07D405/06 , A61K31/4709 , A61K31/5377 , A61K31/506 , A61K31/4725 , A61K31/4545 , C07D401/14 , C07D401/06 , C07D409/14 , A61K31/4525

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

3.

发明授权
N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效

公开(公告)号：US07897618B2

公开(公告)日：2011-03-01

申请号：US11926375

申请日：2007-10-29

申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/4545 , A61K31/4725 , C07D401/14 , C07D405/14

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

4.

发明申请
N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS 失效
标题翻译：作为OREXIN受体拮抗剂的N-阿洛尔循环胺衍生物

公开(公告)号：US20090012122A1

公开(公告)日：2009-01-08

申请号：US11928072

申请日：2007-10-30

申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp

发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/454 , C07D417/14 , A61K31/4545

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

摘要翻译： 公开了具有下式的N-芳酰基环胺衍生物：其中变量如本文所定义，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。

5.

发明授权
Benzamide derivatives as antagonists of orexin receptors 失效
标题翻译：苯甲酰胺衍生物作为食欲素受体的拮抗剂

公开(公告)号：US07078565B2

公开(公告)日：2006-07-18

申请号：US10494011

申请日：2002-10-30

申请人： Wai Ngor Chan , Amanda Johns , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Mythily Vimal

发明人： Wai Ngor Chan , Amanda Johns , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Mythily Vimal

IPC分类号： C07C233/65 , A61K31/165

CPC分类号： C07D271/06 , C07C233/73 , C07C233/77 , C07C233/87 , C07C235/46 , C07C235/84 , C07C255/57 , C07C2603/18 , C07D215/48 , C07D215/50 , C07D217/26 , C07D231/14 , C07D249/06 , C07D277/56 , C07D307/79 , C07D317/68

摘要： Disclosed are phenyl-alkylene benzamides useful as orexin antagonists

摘要翻译： 公开了可用作食欲素拮抗剂的苯基 - 亚烷基苯甲酰胺

6.

发明授权
N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
标题翻译： N-芳酰基环胺衍生物作为食欲素受体拮抗剂

公开(公告)号：US07928125B2

公开(公告)日：2011-04-19

申请号：US11926409

申请日：2007-10-29

申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/454 , A61K31/4525 , C07D401/14

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

摘要翻译： 公开了具有下式的N-芳酰基环胺衍生物：其中变量如本文所定义，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。

7.

发明申请
N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS 失效

公开(公告)号：US20090036442A1

公开(公告)日：2009-02-05

申请号：US11926375

申请日：2007-10-29

申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/454 , A61P3/04 , A61P43/00 , C07D417/14 , C07D401/14 , C07D401/06 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/4545 , A61K31/4525

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

8.

发明授权
N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
标题翻译： N-芳酰基环胺衍生物作为食欲素受体拮抗剂

公开(公告)号：US07470710B2

公开(公告)日：2008-12-30

申请号：US10481133

申请日：2002-06-25

申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp

IPC分类号： A61K31/4525 , A61K31/4535 , A61K31/454 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D407/14

CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04

摘要： This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.

摘要翻译： 本发明涉及式（I）的N-芳酰基环胺衍生物，其中X表示键，氧，NR 3或基团（CH 2），其中n表示1,2或3; Y表示CH 2，CO，CH（OH）或CH 2 CH（OH）; Het是含有至多4个选自N，O和S的杂原子的任选取代的双环杂芳基; Ar2表示任选取代的苯基或含有至多3个选自N，O和S的杂原子的5-或6-元杂环基，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。