公开(公告)号：US10130947B2

公开(公告)日：2018-11-20

申请号：US14649654

申请日：2013-12-05

申请人： Radisens Diagnostics Limited

发明人： Gregory J. Kellogg

IPC分类号： B01L3/00 ,  F16K99/00 ,  G01N33/49

摘要： The invention relates to a microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration-primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimizes disc real-estate and optimizes certain microfluidic processes done in the holding chamber.

公开(公告)号：US20190091686A1

公开(公告)日：2019-03-28

申请号：US16194637

申请日：2018-11-19

申请人： Radisens Diagnostics Limited

发明人： Gregory J. Kellogg ,  David Doolan ,  Donal Cronin

IPC分类号： B01L3/00

摘要： A microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration-primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber.

公开(公告)号：US20150316542A1

公开(公告)日：2015-11-05

申请号：US14649646

申请日：2013-12-05

申请人： RADISENS DIAGNOSTICS LIMITED

发明人： Damian Curtin

IPC分类号： G01N33/542 ,  G01N21/07 ,  G01N21/64

CPC分类号： G01N33/542 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N33/53 ,  G01N33/5432 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/02

摘要： The invention relates to a microfluidic system and method of processing biological samples in microfluidic system comprising the steps of the steps of positioning at least one detection chamber adapted for receiving particles, said particles comprising a reference label and reporter label, wherein the labels exhibit different wavelength properties when irradiated with light; and normalising the particle reporter label by using any detected magnitude in the measured properties of the reference label.

摘要翻译： 本发明涉及一种在微流体系统中处理生物样品的微流体系统和方法，包括以下步骤：定位适于接收颗粒的至少一个检测室，所述颗粒包含参考标记和报道标记，其中标记表现出不同的波长 用光照射时的特性; 并通过使用参考标签的测量特性中的任何检测到的量值来归一化颗粒报道标记物。

公开(公告)号：US10888862B2

公开(公告)日：2021-01-12

申请号：US16194637

申请日：2018-11-19

申请人： Radisens Diagnostics Limited

发明人： Gregory J. Kellogg ,  David Doolan ,  Donal Cronin

IPC分类号： B01L3/00

摘要： A microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration-primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber.

公开(公告)号：US20190314813A1

公开(公告)日：2019-10-17

申请号：US16343176

申请日：2017-10-25

申请人： Radisens Diagnostics Limited

发明人： David Doolan ,  Donal Cronin ,  Eoin O'Nuallain

IPC分类号： B01L3/00

摘要： The invention provides a microfluidic system comprising a cartridge coupled to a motor and adapted to move a fluid sample to a plurality of locations on the cartridge. The cartridge comprises a chevron shaped or substantially V shaped reaction chamber having at least three zones, a first zone positioned near the apex of the V shaped reaction chamber to define a detection zone, a second zone positioned near a first end of the V shaped reaction chamber and a third zone positioned near a second end of the V shaped reaction chamber. The motor and a control module is configured to provide a combination of centrifugal force and gravitational force to move said fluid sample between at least three zones.

公开(公告)号：US20150314289A1

公开(公告)日：2015-11-05

申请号：US14649654

申请日：2013-12-05

申请人： Radisens Diagnostics Limited

发明人： Gregg Kellogg

IPC分类号： B01L3/00 ,  F16K99/00

CPC分类号： B01L3/502738 ,  B01L3/502761 ,  B01L2200/06 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0806 ,  B01L2300/0848 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  F16K99/0063 ,  F16K2099/0084 ,  G01N33/491

摘要： The invention relates to a microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration—primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber.

摘要翻译： 本发明涉及用于处理生物样品的微流体系统，其包括适于保持流体并且在平台上旋转的保持室，所述保持室包括出口，通过该出口，流体流由加速启动阀系统控制，其中， 加速起动阀系统包括毛细管阀和出口通道。 本发明提供了一种新颖的阀门系统，其以低角速度保持流体，消除了对亲水表面的需要，最小化盘的不动产并优化在保持室中进行的某些微流体过程。