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公开(公告)号：US20140224349A1
公开(公告)日：2014-08-14
申请号：US14123731
申请日：2012-06-01
申请人： Jens Ducrée , Robert Gorkin , Charles Nwankire
发明人： Jens Ducrée , Robert Gorkin , Charles Nwankire
IPC分类号： B01L3/00
CPC分类号： B01L3/567 , B01L3/502723 , B01L3/502738 , B01L2200/0621 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , B01L2400/0694 , F16K99/0015 , F16K99/003 , F16K99/0063 , F16K2099/0084 , Y10T137/1692
摘要： Microfluidic devices and in particular microfluidic devices incorporating a valve for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device are described, comprising a sacrificial valve, desirably one that is dissolvable on contact with a fluid or that is configured to disintegrate or dissolve on experiencing a predetermined pressure.
摘要翻译： 描述了微流体装置，特别是包括用于选择性地控制微流体装置内的流体流动的阀的微流体装置。 描述了微流体装置的具体实例，包括牺牲阀，期望地是在与流体接触时可溶解的或者被配置为在经历预定压力时分解或溶解的牺牲阀。
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公开(公告)号：US08778270B2
公开(公告)日：2014-07-15
申请号：US13648081
申请日：2012-10-09
发明人： Jong-myeon Park , Byung-chul Kim
IPC分类号： G01N9/30
CPC分类号： G01N21/07 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0021 , F16K99/0063 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084 , Y10T436/111666 , Y10T436/25375
摘要： An apparatus for separating components and a method of separating components using the apparatus are provided. The apparatus includes: a main chamber which contains a sample that is separated into a plurality of layers by a centrifugal force; a component separating chamber which is connected to the main chamber, and receives a specific layer including specific components among the plurality of layers; a first channel which connects the component separating chamber to the main chamber; and a first channel valve which is disposed in the first channel to control a liquid flowing through the first channel.
摘要翻译： 提供了一种用于分离组件的装置和使用该装置分离组件的方法。 该装置包括：主室，其包含通过离心力分离成多个层的样品; 分离室，其连接到所述主室，并且在所述多个层中接收包括特定成分的特定层; 将部件分离室连接到主室的第一通道; 以及第一通道阀，其设置在第一通道中以控制流过第一通道的液体。
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3.发明授权Centrifugal rotor and method for using the same for delivering biological sample 有权离心转子及其用于输送生物样品的方法公开(公告)号：US08562911B2
公开(公告)日：2013-10-22
申请号：US12700751
申请日：2010-02-05
申请人： Ying-Lan Tsai
发明人： Ying-Lan Tsai
IPC分类号： G01N33/00
CPC分类号： F16K99/0019 , B01L3/502738 , B01L3/502753 , B01L2200/16 , B01L2300/0803 , B01L2300/0867 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688 , F16K99/0001 , F16K99/0034 , F16K99/0063 , F16K2099/0084 , G01N21/07 , G01N35/00069 , G01N2035/00495
摘要： Disclosed herein is a centrifugal rotor for delivering and analyzing biological sample. Chambers within the centrifugal rotor is used to split a biological sample, which comprises biological cellular components and biological fluids, into separate parts under centrifugal force after the biological sample being diluted, metered and distributed by the centrifugal rotor.
摘要翻译： 本文公开了一种用于输送和分析生物样品的离心转子。 离心转子中的室用于在生物样品被离心转子稀释，计量和分配之后，将生物样品（包括生物细胞组分和生物流体）在离心力下分离成分离的部分。
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公开(公告)号：US20180266586A1
公开(公告)日：2018-09-20
申请号：US15757321
申请日：2016-09-30
发明人： Lei Wang , Yao Zhou , Hu Wang , Mingxian Lin , Tongjun Wang , Liang Bai , Guoliang Huang , Dong Wang , Wanli Xing
CPC分类号： F16K99/0013 , B01F5/008 , B01F13/0064 , B01L3/502738 , B01L2200/0647 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2400/0644 , F16K99/0025 , F16K99/0028 , F16K99/0063 , F16K2099/0084
摘要： A microfluidic valve provided herein is configured to mix or capable of mixing a sample and/or a reagent in addition to controlling liquid flow. In one embodiment, the microfluidic valve comprises a rotor (3) and one or more micro-structures (2) that move with the rotation of the rotor (3). In one embodiment, the one or more micro-structures (2) stir and/or mix content in a mixing chamber (5) formed by the rotor (3), a base (1), and a sleeve (4) of the microfluidic valve. A microfluidic chip or chip system comprising one or more of the microfluidic valves, and methods of use, are also provided.
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公开(公告)号：US09221051B2
公开(公告)日：2015-12-29
申请号：US13872686
申请日：2013-04-29
发明人： Christoph Boehm , Susanne Wuerl
CPC分类号： B01L3/502723 , B01L3/502738 , B01L2200/0684 , B01L2200/12 , B01L2300/0803 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0017 , F16K99/0063 , F16K2099/0084
摘要： A microfluidic element for analysis of a fluid sample having a substrate and a microfluidic transport system having a channel structure enclosed by the substrate and a covering layer. The channel structure comprises a channel with two side walls as well as a chamber that is in fluid communication with the channel. The chamber has a chamber wall with an inlet orifice. The channel comprises a channel section and a valve section adjoining the channel section, wherein the valve section is in fluid communication with the inlet orifice in the chamber wall in such a way that a fluid can flow from the channel through the valve section and into the chamber. The valve section has a fluid transport cross-section, which enlarges in flow direction. The fluid transport cross-section in the valve section is greater than the fluid transport cross-section in the preceding channel section.
摘要翻译： 用于分析具有基底的流体样品的微流体元件和具有由基底和覆盖层包围的通道结构的微流体输送系统。 通道结构包括具有两个侧壁的通道以及与通道流体连通的室。 该室具有一个具有入口孔的室壁。 通道包括通道部分和毗邻通道部分的阀部分，其中阀部分与腔室壁中的入口孔流体连通，使得流体可以从通道流过阀部分并进入 房间。 阀部分具有流体输送横截面，其在流动方向上扩大。 阀部分中的流体输送横截面大于前一通道部分中的流体输送横截面。
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公开(公告)号：US20130029313A1
公开(公告)日：2013-01-31
申请号：US13648081
申请日：2012-10-09
发明人： Jong-myeon PARK , Byung-chul KIM
CPC分类号： G01N21/07 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0021 , F16K99/0063 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084 , Y10T436/111666 , Y10T436/25375
摘要： An apparatus for separating components and a method of separating components using the apparatus are provided. The apparatus includes: a main chamber which contains a sample that is separated into a plurality of layers by a centrifugal force; a component separating chamber which is connected to the main chamber, and receives a specific layer including specific components among the plurality of layers; a first channel which connects the component separating chamber to the main chamber; and a first channel valve which is disposed in the first channel to control a liquid flowing through the first channel.
摘要翻译： 提供了一种用于分离组件的装置和使用该装置分离组件的方法。 该装置包括：主室，其包含通过离心力分离成多个层的样品; 分离室，其连接到所述主室，并且在所述多个层中接收包括特定成分的特定层; 将部件分离室连接到主室的第一通道; 以及第一通道阀，其设置在第一通道中以控制流过第一通道的液体。
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公开(公告)号：US08307988B2
公开(公告)日：2012-11-13
申请号：US12952208
申请日：2010-11-23
申请人： Jong-myeon Park , Byung-chul Kim
发明人： Jong-myeon Park , Byung-chul Kim
IPC分类号： B03B5/60
CPC分类号： G01N21/07 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0021 , F16K99/0063 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084 , Y10T436/111666 , Y10T436/25375
摘要： An apparatus for separating components and a method of separating components using the apparatus are provided. The apparatus includes: a main chamber which contains a sample that is separated into a plurality of layers by a centrifugal force; a component separating chamber which is connected to the main chamber, and receives a specific layer including specific components among the plurality of layers; a first channel which connects the component separating chamber to the main chamber; and a first channel valve which is disposed in the first channel to control a liquid flowing through the first channel.
摘要翻译： 提供了一种用于分离组件的装置和使用该装置分离组件的方法。 该装置包括：主室，其包含通过离心力分离成多个层的样品; 分离室，其连接到所述主室，并且在所述多个层中接收包括特定成分的特定层; 将部件分离室连接到主室的第一通道; 以及第一通道阀，其设置在第一通道中以控制流过第一通道的液体。
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公开(公告)号：US20150314289A1
公开(公告)日：2015-11-05
申请号：US14649654
申请日：2013-12-05
发明人： Gregg Kellogg
CPC分类号： B01L3/502738 , B01L3/502761 , B01L2200/06 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2300/0806 , B01L2300/0848 , B01L2300/0864 , B01L2300/087 , B01L2300/088 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0063 , F16K2099/0084 , G01N33/491
摘要： The invention relates to a microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration—primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber.
摘要翻译： 本发明涉及用于处理生物样品的微流体系统，其包括适于保持流体并且在平台上旋转的保持室，所述保持室包括出口，通过该出口，流体流由加速启动阀系统控制，其中， 加速起动阀系统包括毛细管阀和出口通道。 本发明提供了一种新颖的阀门系统，其以低角速度保持流体，消除了对亲水表面的需要，最小化盘的不动产并优化在保持室中进行的某些微流体过程。
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公开(公告)号：US08534319B2
公开(公告)日：2013-09-17
申请号：US12529199
申请日：2008-03-03
申请人： Michel G. Bergeron , Regis Peytavi , Horacio Kido , Marc Madou
发明人： Michel G. Bergeron , Regis Peytavi , Horacio Kido , Marc Madou
IPC分类号： E03B1/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2200/0621 , B01L2300/0803 , B01L2300/0861 , B01L2400/0409 , B01L2400/0688 , F16K99/0021 , F16K99/0063 , F16K2099/0074 , F16K2099/0084 , G01N21/07 , Y10T137/0753 , Y10T137/0989 , Y10T137/218 , Y10T137/2911 , Y10T137/86928 , Y10T137/87917
摘要： Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.
摘要翻译： 使用由虹吸阀组成的串联虹吸结构的共同径向排列的方法和装置，每个虹吸管由毛细管阀分开，以节省流体系统中的径向空间。 这种串联虹吸阀允许在施加连续的向心加速度和施加到旋转平台的减速时，在流体系统中顺序地分配液体。
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10.发明申请CENTRIFUGAL ROTOR AND METHOD FOR USING THE SAME FOR DELIVERING BIOLOGICAL SAMPLE 有权离心转子及其使用方法用于交付生物样品公开(公告)号：US20110195502A1
公开(公告)日：2011-08-11
申请号：US12700751
申请日：2010-02-05
申请人： Ying-Lan TSAI
发明人： Ying-Lan TSAI
CPC分类号： F16K99/0019 , B01L3/502738 , B01L3/502753 , B01L2200/16 , B01L2300/0803 , B01L2300/0867 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688 , F16K99/0001 , F16K99/0034 , F16K99/0063 , F16K2099/0084 , G01N21/07 , G01N35/00069 , G01N2035/00495
摘要： Disclosed herein is a centrifugal rotor for delivering and analyzing biological sample. Chambers within the centrifugal rotor is used to split a biological sample, which comprises biological cellular components and biological fluids, into separate parts under centrifugal force after the biological sample being diluted, metered and distributed by the centrifugal rotor.
摘要翻译： 本文公开了一种用于输送和分析生物样品的离心转子。 离心转子中的室用于在生物样品被离心转子稀释，计量和分配之后，将生物样品（包括生物细胞组分和生物流体）在离心力下分离成分离的部分。
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