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    Method and supply unit for monitoring changes and states in reaction chambers
    1.
    发明申请
    Method and supply unit for monitoring changes and states in reaction chambers 审中-公开
    用于监测反应室中的变化和状态的方法和供应单元

    公开(公告)号：US20070037285A1

    公开(公告)日：2007-02-15

    申请号：US10574338

    申请日：2004-10-01

    申请人： Ralf Ehret ,  Axel Kob ,  Elke Thedinga ,  Heiko Holst

    发明人： Ralf Ehret ,  Axel Kob ,  Elke Thedinga ,  Heiko Holst

    IPC分类号： G01N33/00

    CPC分类号： B01L3/502 ,  B01L2200/0684 ,  B01L2300/046 ,  B01L2300/048 ,  C12M29/00

    摘要： The invention relates to a method for monitoring changes and states in reaction chambers as well as a supply unit which is used for introducing a liquid culture medium during cell culture analyses. The aim of the invention is to allow for an air bubble-free measurement in reaction chambers so as to monitor changes and states therein without using any degassing process. Said aim is achieved by withdrawing or pumping off a fluid from a receptacle via a hose and/or pipe system and conveying said fluid to a supply unit. The fluid drips or flows into a trickling chamber via an inlet duct, said fluid forming a supply above a head and a reaction chamber. The height of the fluid level, and thus the supply volume, is determined with the aid of a suction duct.

    摘要翻译： 本发明涉及用于监测反应室中的变化和状态的方法以及用于在细胞培养分析过程中引入液体培养基的供应单元。 本发明的目的是允许在反应室中进行无气泡测量，以便监测其中的变化和状态，而不使用任何脱气过程。 所述目的通过经由软管和/或管道系统从容器抽出或抽出流体并将所述流体输送到供应单元来实现。 流体通过入口管道滴入或流入滴流室，所述流体在头部和反应室上形成供给。 借助于抽吸管道来确定液位高度以及因此的供应体积。

    Method for examination of a surface layer
    2.
    发明授权
    Method for examination of a surface layer 失效
    表层检查方法

    公开(公告)号：US06656678B1

    公开(公告)日：2003-12-02

    申请号：US09585146

    申请日：2000-06-01

    申请人： Bernhard Wolf ,  Hans-Jürgen Gahle ,  Günter Igel ,  Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann

    发明人： Bernhard Wolf ,  Hans-Jürgen Gahle ,  Günter Igel ,  Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann

    IPC分类号： C12Q100

    CPC分类号： H01L22/24 ,  G01B11/30 ,  G01N21/94

    摘要： In a method for examination of the surface of an object for a topographic and/or a chemical property, the object-surface is impinged with surface-structure selective biocomponents for examination of a topographic property and/or with chemoselective biocomponents for the examination of a chemical property, together with a nutrient medium and/or an osmotic protective medium for the biocomponents. The biocomponents contained in the nutrient medium and/or the osmotic protective medium are in contact with the object-surface or are spaced from the object surface by less than the detection range of the biocomponents. The object surface is then examined with the biocomponents contained in the nutrient medium and/or the osmotic protective medium by determining at least one examination measurement value. The examination measurement value is compared with a reference measurement value, and conclusions can be drawn about the topographic and/or chemical properties of the object from the result of the comparison. Using the method, an object surface can be examined for a topographic and/or chemical property in a simple manner with a high measuring sensitivity.

    摘要翻译： 在用于检查地形和/或化学性质的物体的表面的方法中，物体表面与表面结构选择性生物组分碰撞以检查地形性质和/或化学选择性生物成分用于检查 化学性质，以及生物组分的营养培养基和/或渗透保护介质。 包含在营养培养基和/或渗透保护介质中的生物成分与物体表面接触或与物体表面间隔小于生物成分的检测范围。 然后通过确定至少一个检查测量值用包含在营养培养基和/或渗透保护介质中的生物组分检查物体表面。 将检查测量值与参考测量值进行比较，并从比较结果中得出关于物体的地形和/或化学性质的结论。 使用该方法，可以以高测量灵敏度的简单方式检查物体表面的地形和/或化学特性。

    Measuring device using biological cells or chemical biologically active substances contained in an analyte
    3.
    发明授权
    Measuring device using biological cells or chemical biologically active substances contained in an analyte 失效
    使用分析物中包含的生物细胞或化学生物活性物质的测量装置

    公开(公告)号：US06280586B1

    公开(公告)日：2001-08-28

    申请号：US08930657

    申请日：1997-10-06

    申请人： Bernhard Wolf ,  Ralf Ehret ,  Ulrich Sieben ,  Werner Baumann

    发明人： Bernhard Wolf ,  Ralf Ehret ,  Ulrich Sieben ,  Werner Baumann

    IPC分类号： G01N33543

    CPC分类号： G01N33/54373 ,  G01N27/3276 ,  G01N27/4145

    摘要： A measuring device (1) for measuring or investigating physiological parameters using biological cells or chemical and biologically active substances contained in an analyte (2). The measuring device comprises a sensor (4) with an electronic measurement structure (6) located on a substrate (5). Function-specific receptor cells and/or target cells (7) form part of the sensor (4) and are in direct contact with the measurement structure (6). For measurement, the medium under investigation can be brought into contact with the target cells or receptor cells (7). The measuring device (1) is especially compact in its design and facilitates largely feedback-free investigation of biological or chemical components contained in the analyte.

    摘要翻译： 一种用于使用分析物（2）中包含的生物细胞或化学和生物活性物质来测量或调查生理参数的测量装置（1）。 测量装置包括具有位于基板（5）上的电子测量结构（6）的传感器（4）。 功能特异性受体细胞和/或靶细胞（7）形成传感器（4）的一部分并与测量结构（6）直接接触。 为了测量，所研究的培养基可以与靶细胞或受体细胞接触（7）。 测量装置（1）在其设计中特别紧凑，并且对于分析物中包含的生物或化学成分进行大量无反馈的调查。

    Chip arrangement
    5.
    发明授权
    Chip arrangement 失效
    芯片布置

    公开(公告)号：US06288440B1

    公开(公告)日：2001-09-11

    申请号：US09342697

    申请日：1999-06-29

    申请人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

    发明人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

    IPC分类号： H01L23495

    CPC分类号： H01L23/5385 ,  A61B5/14532 ,  A61B5/1473 ,  G01N33/48707 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).

    摘要翻译： 芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。 至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。 载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部 （10,10'）。 这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且 连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。 在基板（2）和载体芯片（4）之间设置密封件。

    Data model access configuration and customization
    6.
    发明授权
    Data model access configuration and customization 有权
    数据模型访问配置和定制

    公开(公告)号：US08818975B2

    公开(公告)日：2014-08-26

    申请号：US12642286

    申请日：2009-12-18

    申请人： Werner Aigner ,  Ralf Ehret ,  Roman Moehl

    发明人： Werner Aigner ,  Ralf Ehret ,  Roman Moehl

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3056

    摘要： Apparatus, systems, and methods may operate to publish one or more stored back end data models accessible to a user interface and a development environment; to receive a configuration context; to generate derived model attributes by filtering, according to the configuration context, back end data attributes associated with the stored back end data models; to derive a set of mapping rules based on the derived model attributes; and store the set of mapping rules to be used to direct run-time data model request transformation activity. Further activities may include receiving an end-user request from a displayed user interface, transforming the end-user request into a transformed request according to the stored set of mapping rules, and transmitting the transformed request to one of the stored back end data models. Additional apparatus, systems, and methods are disclosed.

    摘要翻译： 设备，系统和方法可以操作以发布用户界面和开发环境可访问的一个或多个存储的后端数据模型; 接收配置上下文; 通过根据配置上下文过滤与所存储的后端数据模型相关联的后端数据属性来生成派生模型属性; 基于导出的模型属性导出一组映射规则; 并存储要用于指导运行时数据模型请求转换活动的映射规则集。 进一步的活动可以包括从显示的用户界面接收最终用户请求，根据所存储的映射规则集将终端用户请求转换成变换后的请求，并将转换的请求发送到所存储的后端数据模型之一。 公开了附加装置，系统和方法。

    Capacity planning of resources
    7.
    发明申请
    Capacity planning of resources 审中-公开
    资源容量规划

    公开(公告)号：US20050222884A1

    公开(公告)日：2005-10-06

    申请号：US10815131

    申请日：2004-03-31

    申请人： Ralf Ehret ,  Achim Magel ,  Andreas Bold ,  Hans-Georg Beuter

    发明人： Ralf Ehret ,  Achim Magel ,  Andreas Bold ,  Hans-Georg Beuter

    IPC分类号： G06Q10/00 ,  G06F17/60

    CPC分类号： G06Q10/06 ,  G06Q10/06311 ,  G06Q10/06312

    摘要： Some implementations provide a resource planning system for receiving a first scheduling request for a resource's time. This first scheduling request may include a date range and the estimated amount of time needed from the resource, but does not necessarily include concrete date and time facts. This first scheduling request may be refined by a second scheduling request, which specifies concrete date and time facts to schedule a portion of the resource's time that was originally requested by the first scheduling request.

    摘要翻译： 一些实现提供了一种用于接收资源时间的第一调度请求的资源规划系统。 该第一调度请求可以包括日期范围和资源所需的估计时间量，但不一定包括具体的日期和时间事实。 该第一调度请求可以通过第二调度请求进行改进，该第二调度请求指定具体的日期和时间事实以调度最初由第一调度请求请求的资源的时间部分。

    Business process visibility at real time
    8.
    发明授权
    Business process visibility at real time 有权
    业务流程实时可见性

    公开(公告)号：US08600792B2

    公开(公告)日：2013-12-03

    申请号：US12977064

    申请日：2010-12-23

    申请人： Bernhard Drittler ,  Ralf Ehret ,  Jens-Christoph Nolte ,  Bernd Schmitt

    发明人： Bernhard Drittler ,  Ralf Ehret ,  Jens-Christoph Nolte ,  Bernd Schmitt

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/063

    摘要： Various embodiments of systems and methods for providing business process visibility at real time are described herein. One or more business activity events are received at a local business activity event manager. Further, business process binding information associated with the one or more business activity events is retrieved at the business activity manager from a business process model manager. A relationship of the one or more business activity events with a business process using the business process binding is identified at the business activity event manager. Upon determination, a business process log manager is triggered for logging a business activity log of a business process instance at real time. Furthermore, the business activity log is extracted to monitor and analyze the business process instance at real time.

    摘要翻译： 这里描述了用于实时提供业务过程可视性的系统和方法的各种实施例。 一个或多个业务活动事件在本地业务活动事件管理器处收到。 此外，业务活动管理器从业务流程模型管理器检索与一个或多个业务活动事件相关联的业务流程绑定信息。 业务活动事件管理器识别一个或多个业务活动事件与使用业务流程绑定的业务流程的关系。 一旦确定，触发业务流程日志管理器即可实时记录业务流程实例的业务活动日志。 此外，提取业务活动日志以实时监控和分析业务流程实例。

    DEVICE FOR PERFORMING ANALYSIS ON CELL CULTURES
    9.
    发明申请
    DEVICE FOR PERFORMING ANALYSIS ON CELL CULTURES 有权

    公开(公告)号：US20080145922A1

    公开(公告)日：2008-06-19

    申请号：US11952219

    申请日：2007-12-07

    申请人： Mirko Lehmann ,  Martin Brischwein ,  Werner Baumann ,  Ralf Ehret ,  Ingo Freund

    发明人： Mirko Lehmann ,  Martin Brischwein ,  Werner Baumann ,  Ralf Ehret ,  Ingo Freund

    IPC分类号： C12M1/00

    CPC分类号： C12M41/46 ,  C12M27/02 ,  C12M33/04

    摘要： A device (1) for the carrying out of investigations on cell cultures (2) which take place in a liquid culture medium (4). The device possesses at least a receptacle (3) to contain the culture medium (4) including the cell culture (2), wherein one or more sensors (6) for measurement of the cell culture activities is provided and wherein the receptacle (3) has at least an opening for the adding and the removal of liquid culture medium (4) and the like. A separating element (7) can be introduced into the open upper part of the receptacle (3) and can be brought within the said receptacle (3) in a position close to the bottom (5), in which the said separating element (7) makes a boundary forming a partial space (8) which has a small volume in relation to the entire volume of the receptacle (3). Further, a flow channel (9) is provided, which first, communicates with the small volume partial space (8), and second, communicates with the said reservoir (14). This flow channel (9) and/or the sensors (6) are placed in the area of the small volume partial space (8). By means of the capability for adjustment of the separating element (7) as to its distance from the bottom of the receptacle (3), in the neighborhood of the cell culture (2) a microreaction volume exactly fitting the current requirements can be adjusted. By means of the flow channel (9), the cell culture (2) in the small volume partial space (8) stands in fluid communication with that in the reservoir. For the regeneration of the cell culture solution in the small volume partial space, the separating element (7) can be elevated and depressed, or it is possible, to inject into the small volume partial space of the receptacle (3) a quantity of liquid and by means of a through-flow channel. In this case, a convective mixing of fresh and spent medium takes place through the flow channel (9) between the small volume partial space and the reservoir (14).