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1.发明申请Oligonucleotides which inhibit expression of the OB-RGRP protein and method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor 有权抑制OB-RGRP蛋白表达的寡核苷酸和用于检测修饰OB-RGRP家族的蛋白质与瘦蛋白受体之间的相互作用的化合物的方法公开(公告)号：US20050009042A1
公开(公告)日：2005-01-13
申请号：US10774721
申请日：2004-02-09
申请人： Ralf Jockers , Cyril Couturier , Eugen Uhlmann
发明人： Ralf Jockers , Cyril Couturier , Eugen Uhlmann
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2310/53 , G01N2333/715 , C12N2310/3521
摘要： The present application relates to oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions. It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
摘要翻译： 本申请涉及抑制OB-RGRP蛋白表达的寡核苷酸及其用于预防和/或治疗瘦素相关病理状况的用途。 它还涉及用于检测修饰OB-RGRP家族的蛋白质与瘦蛋白受体之间的相互作用的化合物的方法。 该检测可以通过测量由这些蛋白质组成的融合蛋白质和能量供体和受体蛋白质之间的能量转移来进行。
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公开(公告)号：US07884084B2
公开(公告)日：2011-02-08
申请号：US10774721
申请日：2004-02-09
申请人： Ralf Jockers , Cyril Couturier , Eugen Uhlmann
发明人： Ralf Jockers , Cyril Couturier , Eugen Uhlmann
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2310/53 , G01N2333/715 , C12N2310/3521
摘要： The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions.It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
摘要翻译： 本申请涉及抑制OB-RGRP蛋白表达的反义寡核苷酸及其用于预防和/或治疗瘦素相关病理状况的用途。 它还涉及用于检测修饰OB-RGRP家族的蛋白质与瘦蛋白受体之间的相互作用的化合物的方法。 该检测可以通过测量由这些蛋白质组成的融合蛋白质和能量供体和受体蛋白质之间的能量转移来进行。
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公开(公告)号：US07618818B2
公开(公告)日：2009-11-17
申请号：US11697907
申请日：2007-04-09
申请人： Ralf Jockers , Cyril Couturier
发明人： Ralf Jockers , Cyril Couturier
CPC分类号： C07K14/715 , C07K2319/00 , G01N33/6893 , G01N33/74 , G01N2500/00
摘要： The present invention relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins comprising a leptin receptor and an energy donor protein or an energy acceptor acceptor protein proteins. The present invention also relates to fusion proteins for implementing said method.
摘要翻译： 本发明涉及通过测量包含瘦蛋白受体和能量供体蛋白或能量受体蛋白的融合蛋白之间的能量转移来检测瘦蛋白受体配体的方法。 本发明还涉及用于实现所述方法的融合蛋白。
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公开(公告)号：US20070178560A1
公开(公告)日：2007-08-02
申请号：US11697907
申请日：2007-04-09
申请人： Ralf JOCKERS , Cyril COUTURIER
发明人： Ralf JOCKERS , Cyril COUTURIER
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/04 , A61K31/704
CPC分类号： C07K14/715 , C07K2319/00 , G01N33/6893 , G01N33/74 , G01N2500/00
摘要： The present application relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins composed of leptin receptors and of energy donor and acceptor proteins. It also relates to fusion proteins for implementing this method.
摘要翻译： 本申请涉及通过测量由瘦素受体和能量供体和受体蛋白组成的融合蛋白之间的能量转移来检测瘦蛋白受体配体的方法。 它还涉及用于实现该方法的融合蛋白。
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公开(公告)号：US07211399B2
公开(公告)日：2007-05-01
申请号：US10373624
申请日：2003-02-25
申请人： Ralf Jockers , Cyril Couturier
发明人： Ralf Jockers , Cyril Couturier
CPC分类号： C07K14/715 , C07K2319/00 , G01N33/6893 , G01N33/74 , G01N2500/00
摘要： The present invention relates to a method for detecting leptin receptor ligands using resonance energy transfer between fusion proteins comprising a leptin receptor and energy donor protein and a leptin receptor and energy acceptor protein. The present invention also relates to the fusion proteins for implementing said method.
摘要翻译： 本发明涉及使用包含瘦蛋白受体和能量供体蛋白的融合蛋白与瘦蛋白受体和能量受体蛋白之间的共振能量转移来检测瘦素受体配体的方法。 本发明还涉及用于实现所述方法的融合蛋白。
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