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公开(公告)号：US20120222980A1
公开(公告)日：2012-09-06
申请号：US13368781
申请日：2012-02-08
CPC分类号： B65D55/08 , B65D51/18 , B65D55/14 , B65D63/10 , B65D2255/00 , Y10S206/807
摘要： Tamper-evident package comprises a container, a primary cap, and a secondary cap. The container comprises a sidewall defining a chamber and a rim defining a mouth to the chamber. The primary cap is removably-attachable to the rim of the container to selectively close the mouth of the container. The secondary cap is positioned over the primary cap to prevent removal of the primary cap when positioned thereover. The secondary cap includes a single-use lock, such as a cable tie, to secure the secondary cap in position over the primary cap. The package thus provides evidence that someone has tampered with or attempted to tamper with the container if the single-use lock is removed or damaged. Method of using the tamper-evident package is also disclosed.
摘要翻译： 防篡改的包装包括容器，初级帽和次级帽。 容器包括侧壁，该侧壁限定腔室和限定到腔室的口的边缘。 主帽可拆卸地附接到容器的边缘以选择性地关闭容器的口部。 次级盖定位在主帽上方，以防止在其上定位时移除主帽。 辅助盖包括一次性使用的锁，例如电缆扎带，以将副盖固定在主帽上的适当位置。 因此，该包装提供了证据，证明如果一次性使用的锁被移除或损坏，有人已经篡改或试图篡改集装箱。 还公开了使用防窃启包装的方法。
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公开(公告)号：US07192735B2
公开(公告)日：2007-03-20
申请号：US10261049
申请日：2002-09-30
IPC分类号： C12P21/02 , C12P1/00 , C12P39/00 , C12N9/10 , C12N1/19 , C12N1/21 , C12N5/04 , C12N5/06 , A61K38/04 , C07H21/04
CPC分类号： C12N9/1258 , C12N9/1029 , C12Q1/48 , G01N33/5005 , G01N33/569
摘要： The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, or synthetically. Accordingly, the invention provides compositions and kits including phosphopantetheinyl transferases and host cells expressing phosphopantetheinyl transferases. The invention also provides nucleic acids encoding phosphopantetheinyl transferases and vectors comprising such nucleic acids. The invention further provides methods for phosphopantetheinylating a substrate in vitro or in vivo and methods for producing antibiotics in vitro or in vivo.
摘要翻译： 本发明涉及分离的磷酸二氢乙烯基转移酶，例如大肠杆菌酰基载体蛋白合成酶，其将磷酸泛酰乙烯基转移到基底上。 该酶可以从天然来源纯化，重组产生或合成产生。 因此，本发明提供了组合物和试剂盒，其包括磷酸泛酰乙酰转移酶和表达磷酸聚乙二炔转移酶的宿主细胞。 本发明还提供了编码磷酸泛酰乙酰转移酶的核酸和包含此类核酸的载体。 本发明进一步提供了体外或体内磷酸化乙酰化底物的方法以及在体外或体内生产抗生素的方法。
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公开(公告)号：US09033153B2
公开(公告)日：2015-05-19
申请号：US13368781
申请日：2012-02-08
CPC分类号： B65D55/08 , B65D51/18 , B65D55/14 , B65D63/10 , B65D2255/00 , Y10S206/807
摘要： Tamper-evident package comprises a container, a primary cap, and a secondary cap. The container comprises a sidewall defining a chamber and a rim defining a mouth to the chamber. The primary cap is removably-attachable to the rim of the container to selectively close the mouth of the container. The secondary cap is positioned over the primary cap to prevent removal of the primary cap when positioned thereover. The secondary cap includes a single-use lock, such as a cable tie, to secure the secondary cap in position over the primary cap. The package thus provides evidence that someone has tampered with or attempted to tamper with the container if the single-use lock is removed or damaged. Method of using the tamper-evident package is also disclosed.
摘要翻译： 防篡改的包装包括容器，初级帽和次级帽。 容器包括侧壁，该侧壁限定腔室和限定到腔室的口的边缘。 主帽可拆卸地附接到容器的边缘以选择性地关闭容器的口部。 次级盖定位在主帽上方，以防止在其上定位时移除主帽。 辅助盖包括一次性使用的锁，例如电缆扎带，以将副盖固定在主帽上的适当位置。 因此，该包装提供了证据，证明如果一次性使用的锁被移除或损坏，有人已经篡改或试图篡改集装箱。 还公开了使用防窃启包装的方法。
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公开(公告)号：US06579695B1
公开(公告)日：2003-06-17
申请号：US08728742
申请日：1996-10-11
IPC分类号： C12P1926
CPC分类号： C12N9/1258 , C12N9/1029 , C12Q1/48 , G01N33/5005 , G01N33/569
摘要： The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, or synthetically. Accordingly, the invention provides compositions and kits including phosphopantetheinyl transferases and host cells expressing phosphopantetheinyl transferases. The invention also provides nucleic acids encoding phosphopantetheinyl transferases and vectors comprising such nucleic acids. The invention further provides methods for phosphopantetheinylating a substrate in vitro or in vivo and methods for producing antibiotics in vitro or in vivo.
摘要翻译： 本发明涉及分离的磷酸二氢乙烯基转移酶，例如大肠杆菌酰基载体蛋白质合酶，其将磷酸泛酰乙烯基转移到基底上。 该酶可以从天然来源纯化，重组产生或合成产生。 因此，本发明提供了组合物和试剂盒，其包括磷酸泛酰乙酰转移酶和表达磷酸聚乙二炔转移酶的宿主细胞。 本发明还提供了编码磷酸泛酰乙酰转移酶的核酸和包含此类核酸的载体。 本发明进一步提供了体外或体内磷酸化乙酰化底物的方法以及在体外或体内生产抗生素的方法。
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