公开(公告)号：US6124597A

公开(公告)日：2000-09-26

申请号：US889017

申请日：1997-07-07

申请人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

发明人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/64

CPC分类号： G01N21/6486 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  A61B5/0071 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N2021/6484 ,  G01N2201/06193

摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

摘要翻译： 激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光 样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测 返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

公开(公告)号：USRE39672E1

公开(公告)日：2007-06-05

申请号：US10056335

申请日：2002-01-23

申请人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

发明人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

IPC分类号： G01N21/64

CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

摘要翻译： 激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光 样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测 返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

公开(公告)号：US07264592B2

公开(公告)日：2007-09-04

申请号：US10607878

申请日：2003-06-27

申请人： Ramez E. N. Shehada

发明人： Ramez E. N. Shehada

IPC分类号： A61B8/00

CPC分类号： A61B8/0825 ,  A61B8/406 ,  Y10S128/915

摘要： A breast tomography scanner including a stationary chamber configured to hold fluid, a movable chamber within the stationary chamber configured to hold fluid, and breast scanning apparatus. Various configurations for housing the ultrasonic transducers are disclosed, along with filling and draining apparatus, leakage protections turbulence-reduction configurations and control systems.

摘要翻译： 一种乳房断层摄影扫描器，包括被配置为保持流体的静止室，在被配置为保持流体的固定室内的可动腔和乳房扫描装置。 公开了用于容纳超声波换能器的各种配置，以及填充和排放装置，泄漏保护湍流减少配置和控制系统。

公开(公告)号：US06697657B1

公开(公告)日：2004-02-24

申请号：US09605176

申请日：2000-06-28

申请人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

发明人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

IPC分类号： A61B500

CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

摘要： Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

摘要翻译： 激光诱导荧光衰减激光诱导荧光衰减光谱法（LIFAS）的方法和装置，特别是用于检测生物组织缺血和缺氧的方法和装置。 LIFAS方法和装置优选地包括适于发射针对样品中的样品体积的辐射的源，以产生来自样品的返回光，这种返回光包括由样品的调制产生的调制的返回光，第一传感器，位移 距离样品体积的第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，与样品体积相距离第二距离，用于监测返回光，并产生指示的第二信号 的返回光的强度，以及与第一传感器和第二传感器相关联的处理器并且适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。