公开(公告)号：US08909004B2

公开(公告)日：2014-12-09

申请号：US13892274

申请日：2013-05-11

申请人： Claudio Oliveira Egalon

发明人： Claudio Oliveira Egalon

IPC分类号： G02B6/00 ,  G01F23/292 ,  G01N21/17 ,  G01N21/64 ,  G01D5/353 ,  G01N21/77 ,  G01N21/63

CPC分类号： G01N21/251 ,  G01D5/353 ,  G01D5/35345 ,  G01D5/35387 ,  G01F23/2927 ,  G01N21/17 ,  G01N21/64 ,  G01N21/645 ,  G01N21/648 ,  G01N21/76 ,  G01N21/7703 ,  G01N2021/635 ,  G01N2021/6484 ,  G01N2021/7736 ,  G01N2201/06193 ,  G01N2201/062 ,  G01N2201/088 ,  G02B6/00

摘要： A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.

摘要翻译： 提供不需要敏感涂层的侧面照明多点多参数光纤传感器。 该传感器包括具有至少一个去除的包层部分作为敏感区域的光纤，该侧面照射光纤的至少一个探测光源，电源，检测器，信号处理器和显示器。 敏感光纤受到可以荧光，磷光吸收，吸收和/或散射探测光的被测量介质的存在的光学影响。 该探测光由光纤芯引向测量光强度的检测器，该光强度与被测量相关。

公开(公告)号：US08728399B2

公开(公告)日：2014-05-20

申请号：US13486399

申请日：2012-06-01

申请人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

IPC分类号： G01N21/64 ,  G01N21/66

CPC分类号： G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

摘要： The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

摘要翻译： 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

公开(公告)号：US20130003043A1

公开(公告)日：2013-01-03

申请号：US13540001

申请日：2012-07-02

申请人： Joachim Hoenes ,  Frederic Wehowski ,  Reinhold Mischler ,  Herbert Harttig

发明人： Joachim Hoenes ,  Frederic Wehowski ,  Reinhold Mischler ,  Herbert Harttig

IPC分类号： G01N21/59

CPC分类号： G01N21/3151 ,  G01N21/8483 ,  G01N2021/3155 ,  G01N2201/06193 ,  G01N2201/0696

摘要： A measuring system for determining blood glucose includes a photometric measuring unit with a light source and a detector, and an analytical test element, to which a body fluid sample can be applied, and which can be placed in a beam path between the light source and the detector for optical detection of an analyte. For an improved multi-wavelength measurement, it is proposed that the light source includes a first emitter that can be actuated in a first wavelength range to emit pulsating alternating light and a second emitter that can be excited in a second wavelength range to emit fluorescent light.

摘要翻译： 一种用于测定血糖的测量系统包括具有光源和检测器的测光单元以及能够施加体液样品的分析测试元件，并且其可以放置在光源和 用于光学检测分析物的检测器。 对于改进的多波长测量，提出了光源包括能够在第一波长范围内致动以发射脉动交替光的第一发射器和可在第二波长范围内被激发以发射荧光的第二发射极 。

公开(公告)号：US20110057118A1

公开(公告)日：2011-03-10

申请号：US12869788

申请日：2010-08-27

申请人： Yan Zheng ,  Jingyu Bian ,  Shufan Geng ,  Ruifu Yang ,  Lei Zhou ,  Huijie Huang ,  Youbao Zhang ,  Lihua Huang

发明人： Yan Zheng ,  Jingyu Bian ,  Shufan Geng ,  Ruifu Yang ,  Lei Zhou ,  Huijie Huang ,  Youbao Zhang ,  Lihua Huang

IPC分类号： G01J1/58

CPC分类号： G01N21/6428 ,  B82Y15/00 ,  B82Y20/00 ,  G01N2021/6441 ,  G01N2201/06193

摘要： A method of indirect emission by nano-materials includes providing an infrared up-conversion phosphor 1 (weight ratio) and a long-wave ultraviolet phosphor 0.01-10 (weight ratio); treating both surfaces of the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; mixing the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; exciting the infrared up-conversion phosphor by a near-infrared laser with a wavelength of 980 mn to emit blue light as a secondary excitation lightsource; exciting the long-wave ultraviolet phosphor by the blue light to emit a visible light. Biological reactions can be conveniently detected by detecting the visible light.

摘要翻译： 纳米材料间接发射的方法包括提供红外线上转换荧光体1（重量比）和长波紫外线荧光粉0.01-10（重量比）; 处理红外线上变换荧光体和长波紫外线荧光体的两面; 混合红外线上转换荧光体和长波紫外线荧光体; 通过波长980nm的近红外激光激发红外上转换荧光体，发射蓝光作为次级激发光源; 通过蓝光激发长波紫外线荧光体发出可见光。 通过检测可见光可以方便地检测生物反应。

公开(公告)号：US07589329B1

公开(公告)日：2009-09-15

申请号：US12108446

申请日：2008-04-23

申请人： Daniel W. Youngner

发明人： Daniel W. Youngner

IPC分类号： G01N21/64

CPC分类号： G01L9/002 ,  G01N2201/06193

摘要： An optical-based sensor system that detects emitted light. An exemplary embodiment of an optical-based sensor has a substrate with a surface and an internal region; a shell disposed above the substrate surface, the shell operable to receive incident light characterized by a first wavelength; a beam disposed below the shell; a photodiode on the substrate surface below the beam, and in response to receiving a first portion of the incident light, the photodiode is operable to generate a charge such that a motion is induced to resonate at a resonate frequency; and a phosphor in the substrate internal region and operable to receive a second portion of the incident light, the phosphor further operable to emit light characterized by at least one second wavelength that is different from the first wavelength of the incident light, the phosphor emitted light transmitted through the photodiode, the beam, and the shell.

摘要翻译： 一种检测发射光的光学传感器系统。 光学传感器的示例性实施例具有具有表面和内部区域的基板; 壳体，其设置在所述衬底表面上方，所述壳体可操作以接收以第一波长为特征的入射光; 设置在壳体下方的梁; 在光束下面的衬底表面上的光电二极管，并且响应于接收到入射光的第一部分，光电二极管可操作地产生电荷，使得运动被感应为谐振频率谐振; 以及在所述基板内部区域中的荧光体，并且可操作以接收所述入射光的第二部分，所述荧光体还可操作以发射特征在于与所述入射光的第一波长不同的至少一个第二波长的光，所述荧光体发射光 透过光电二极管，光束和外壳。

公开(公告)号：US20070281322A1

公开(公告)日：2007-12-06

申请号：US11805185

申请日：2007-05-21

申请人： Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

发明人： Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

IPC分类号： G01N33/53 ,  G01J3/427

CPC分类号： G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

摘要： The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

摘要翻译： 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

公开(公告)号：US20070249917A1

公开(公告)日：2007-10-25

申请号：US11811083

申请日：2007-06-08

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： A61B5/00

CPC分类号： A61B5/0066 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/4795 ,  G01N21/6428 ,  G01N2021/1787 ,  G01N2201/06193 ,  Y10S436/805 ,  Y10T436/144444

摘要： There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and/or, in particular, the substance within the layer(s), may be measured, evaluated and/or analyzed.

公开(公告)号：USRE39672E1

公开(公告)日：2007-06-05

申请号：US10056335

申请日：2002-01-23

申请人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

发明人： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

IPC分类号： G01N21/64

CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

摘要： The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

摘要翻译： 激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光 样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测 返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

公开(公告)号：US5039868A

公开(公告)日：1991-08-13

申请号：US439943

申请日：1989-11-22

申请人： Shigeki Kobayashi ,  Hideaki Takahara

发明人： Shigeki Kobayashi ,  Hideaki Takahara

IPC分类号： G01N21/956

CPC分类号： G01N21/95684 ,  G01N2021/6439 ,  G01N2021/8887 ,  G01N2021/95646 ,  G01N2201/06193

摘要： Disclosed is a substrate inspecting method in which light is projected to a part (21) mounted on a substrate (20) from a ring-shaped light source (29), reflected light form the surface of a soldered portion (44) is imaged by an imaging unit (32) and the nature of the soldered portion is inspected by its imaged pattern, characterized by applying fluorescent agents (70) to at least the periphery of the soldered portion of the mounted part on the surface of the substrate, exposing the surface coated with the fluorescent agents to light from the ring-shaped light source to excite the fluorescent agents, exposing the surface of the soldered portion to secondary illuminating light produced by the fluorescent agents to image its reflected light.

摘要翻译： 公开了一种基板检查方法，其中光从环形光源（29）投射到安装在基板（20）上的部分（21）上，形成焊接部分（44）的表面的反射光通过 成像单元（32）和焊接部分的性质通过其成像图案进行检查，其特征在于将荧光剂（70）至少施加到基板表面上的安装部分的焊接部分的周边， 将荧光剂表面涂覆到来自环形光源的光以激发荧光剂，将焊接部分的表面暴露于由荧光剂产生的二次照明光以对其反射光进行成像。

公开(公告)号：US20240328946A1

公开(公告)日：2024-10-03

申请号：US18267586

申请日：2022-10-13

申请人： Xiamen University

发明人： Donghui LI ,  Yan ZHANG ,  Ping HUANG ,  Yabin DENG

IPC分类号： G01N21/64

CPC分类号： G01N21/643 ,  G01N2201/06193 ,  G01N2201/127

摘要： The present disclosure provides a fluorescence analysis method for lithium ion determination using free-base phthalocyanine (FBPc) as a molecular probe, and relates to the technical field of fluorescent probes. The method includes the following steps: adding an alkaline organic medium separately into a plurality of reaction vessels, and adding a phthalocyanine organic solution having a same volume as that of the alkaline organic medium; adding lithium ion organic solutions with increasing concentrations in sequence; diluting an obtained reaction system, allowing to stand to conduct a reaction, scanning a fluorescence spectrum of the reaction system, and determining a relative fluorescence intensity at a fluorescence peak. A determination principle is that in organic media, especially an alkaline organic medium, lithium ions can react with the FBPc to emit strong red fluorescence, and generation of the fluorescence has the remarkable characteristics of ultra-sensitivity and high specificity.