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31 条记录 (耗时 0.025 秒)

    Hydroxy-aryl metal chelates for diagnostic NMR imaging
    3.
    发明授权
    Hydroxy-aryl metal chelates for diagnostic NMR imaging 失效
    用于诊断NMR成像的羟基 - 芳基金属螯合物

    公开(公告)号：US5422096A

    公开(公告)日：1995-06-06

    申请号：US254963

    申请日：1994-06-07

    申请人： Randall B. Lauffer ,  Scott K. Larsen

    发明人： Randall B. Lauffer ,  Scott K. Larsen

    IPC分类号： A61K49/06 ,  A61K49/00

    CPC分类号： A61K49/06 ,  Y10T436/24

    摘要： An NMR contrast agent composition contains a complex of a selected metal ion and a selected ligand. The ion is selected from the group consisting of gadolinium (III), iron (III), manganese (II), manganese (III), chromium (III), copper (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), and europium (III); and the ligand is a linear two-nitrogen compound having one 2-hydroxy-aryl group at one of the nitrogens; or the ligand is a linear two-nitrogen compound having one or two 2-hydroxy-aryl groups at each of the nitrogens; or the ligand is a linear three-, four-, or five-nitrogen compound having one or two 2-hydroxy-aryl substituents at each of one or more of the nitrogens, or the ligand is a heterocyclic compound having a ring containing three or four nitrogens, and having a 2-hydroxy-aryl substitent at one or more of the nitrogens; or the ligand is a heterocyclic compound having a ring containing 4 nitrogens, and having a carboxyl group at two of the nitrogens and an aromatic substituent at the other two of the nitrogens.

    摘要翻译： NMR造影剂组合物含有所选择的金属离子和所选择的配体的络合物。 离子选自钆（III），铁（III），锰（II），锰（III），铬（III），铜（II），镝（III），铽（III），钬 （III），铒（III），铕（II）和铕（III）; 并且配位体是在一个氮原子上具有一个2-羟基 - 芳基的直链二氮化合物; 或者配体是在每个氮原子上具有一个或两个2-羟基 - 芳基的线性二氮化合物; 或者配体是在一个或多个氮的每一个上具有一个或两个2-羟基 - 芳基取代基的线性三，四或五氮化合物，或者配体是具有环的三价或 四个氮，并且在一个或多个氮上具有2-羟基 - 芳基取代基; 或者配体是具有含有4个氮的环的杂环化合物，并且在两个氮原子处具有羧基，在另外两个氮原子具有芳香族取代基。

    Vivo enhancement of NMR relaxivity
    4.
    发明授权
    Vivo enhancement of NMR relaxivity 失效
    体内增强核磁共振弛豫度

    公开(公告)号：US4880008A

    公开(公告)日：1989-11-14

    申请号：US860540

    申请日：1986-05-07

    申请人： Randall B. Lauffer

    发明人： Randall B. Lauffer

    IPC分类号： A61K49/06

    CPC分类号： A61K49/06

    摘要： A method of decreasing the NMR relaxation times (T.sub.1 or T.sub.2) of water protons in contact with a biological tissue, the method involving administering to a human patient an NMR contrast agent comprising a paramagnetic ion complexed with a chelating substance, the contrast agent being characterized in that it is capable of binding non-covalently and non-immunologically to a component of the tissue, and as a result of such binding is capable of enhancing relaxivity of the water protons by a factor of at least 2, compared to the relaxivity induced by the paramagnetic substance alone free in solution, and subjecting the patient to NMR imaging.

    摘要翻译： 一种降低与生物组织接触的水质子的NMR松弛时间（T1或T2）的方法，该方法涉及向人类患者施用包含与螯合物质复合的顺磁离子的NMR造影剂，所述造影剂被表征 因为其能够非共价和非免疫学地结合组织的组分，并且作为这种结合的结果，与诱导的松弛度相比，能够将水质的松弛性提高至少2倍 通过单独的顺磁性物质在溶液中游离，并对患者进行NMR成像。

    Diagnostic imaging contrast agents with extended blood retention
    6.
    发明授权
    Diagnostic imaging contrast agents with extended blood retention 失效
    具有延长血液保留性的诊断成像造影剂

    公开(公告)号：US08017105B2

    公开(公告)日：2011-09-13

    申请号：US11472842

    申请日：2006-06-22

    申请人： Thomas J. McMurry ,  Hironao Sijiki ,  Daniel M. Scott ,  Randall B. Lauffer

    发明人： Thomas J. McMurry ,  Hironao Sijiki ,  Daniel M. Scott ,  Randall B. Lauffer

    IPC分类号： A61B5/055

    CPC分类号： A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

    摘要翻译： 本发明涉及用于具有延长血液保留的诊断成像的造影剂。 特别地，本发明涉及以图像增强部分（IEM）为特征的新化合物; 蛋白质血浆结合部分（PPBM）; 和血液半衰期延长部分（BHEM）。 本发明还涉及包含这些化合物的药物组合物以及使用化合物和组合物用于诊断成像的血液半衰期延长和对比度增强的方法。

    Systems and methods for targeted magnetic resonance imaging of the vascular system
    8.
    发明授权
    Systems and methods for targeted magnetic resonance imaging of the vascular system 失效
    用于血管系统靶向磁共振成像的系统和方法

    公开(公告)号：US07412279B2

    公开(公告)日：2008-08-12

    申请号：US10209416

    申请日：2002-07-30

    申请人： Robert M. Weisskoff ,  Peter D. Caravan ,  Sonia Witte ,  Randall B. Lauffer ,  Alan P. Carpenter, Jr.

    发明人： Robert M. Weisskoff ,  Peter D. Caravan ,  Sonia Witte ,  Randall B. Lauffer ,  Alan P. Carpenter, Jr.

    IPC分类号： A61B5/05

    CPC分类号： A61B5/416 ,  A61B5/055

    摘要： This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.

    摘要翻译： 本发明涉及基于MRI的方法和系统，其可用于诊断和临床评估血管系统内心血管疾病相关的静止目标（例如血栓和动脉粥样硬化病变）的存在，位置和大小。 本发明的方法和系统允许从MRI图像获得改进的解剖信息，并允许临床医生开发更有效的治疗计划。 一方面，本发明提供一种确定哺乳动物血管系统中静止靶的存在或不存在的方法，其中在施用靶向MRI对比后获取表示血管系统和静止靶的图像的两个MRI数据集 代理商 在另一个实施方案中，向哺乳动物施用靶向MRI造影剂和血管MRI造影剂，并且获取血管MRI和靶向MRI数据组。

    Diagnostic imaging contrast agents with extended blood retention
    9.
    发明授权
    Diagnostic imaging contrast agents with extended blood retention 有权
    具有延长血液保留性的诊断成像造影剂

    公开(公告)号：US07229606B2

    公开(公告)日：2007-06-12

    申请号：US10755507

    申请日：2004-01-12

    申请人： Thomas J. McMurry ,  Hironao Sijiki ,  Daniel M. Scott ,  Randall B. Lauffer

    发明人： Thomas J. McMurry ,  Hironao Sijiki ,  Daniel M. Scott ,  Randall B. Lauffer

    IPC分类号： A61B5/055

    CPC分类号： A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

    摘要翻译： 本发明涉及用于具有延长血液保留的诊断成像的造影剂。 特别地，本发明涉及以图像增强部分（IEM）为特征的新化合物; 蛋白质血浆结合部分（PPBM）; 和血液半衰期延长部分（BHEM）。 本发明还涉及包含这些化合物的药物组合物以及使用化合物和组合物用于诊断成像的血液半衰期延长和对比度增强的方法。