公开(公告)号：US20080319344A1

公开(公告)日：2008-12-25

申请号：US11954994

申请日：2007-12-12

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

IPC分类号： A61B5/00

CPC分类号： A61M39/10

摘要： The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device.A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises:a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; anda male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.According to the invention, this second line is formed from a flexible microtube pushed right through the male connector beyond the male end, the free end of the second line pressing in a sealed manner against the female end so as to minimize the dead volume between the first line and the male connector.

摘要翻译： 本发明涉及流体连接装置以及使用该装置采集流体微样品的连续自动化系统和方法。 根据本发明的装置（20），其旨在经由第一开口连接到第一线（21）并且包括第二线（28）经过的第二开口，包括：阴性流体连接器（22） ），其限定所述第一开口并且具有终止于所述第一线打开的阴端（24）中的内部配合表面（23） 以及限定所述第二开口的阳性流体连接器（25），所述第二开口经由其外表面（26）装配到所述阴连接器中并且经由所述阴连接器内部的阳性径向端部（27）终止。 根据本发明，该第二线由柔性微型管形成，该柔性微型管直接通过阳型连接器推动超过阳端，第二线的自由端以密封的方式压靠阴性端，从而最小化 第一行和公连接器。

公开(公告)号：US08092445B2

公开(公告)日：2012-01-10

申请号：US11954994

申请日：2007-12-12

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

IPC分类号： A61M25/16

CPC分类号： A61M39/10

摘要： The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device.A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector. According to the invention, this second line is formed from a flexible microtube pushed right through the male connector beyond the male end, the free end of the second line pressing in a sealed manner against the female end so as to minimize the dead volume between the first line and the male connector.

摘要翻译： 本发明涉及流体连接装置以及使用该装置采集流体微样品的连续自动化系统和方法。 根据本发明的装置（20），其旨在经由第一开口连接到第一线（21）并且包括第二线（28）经过的第二开口，包括：阴性流体连接器（22） ），其限定所述第一开口并且具有终止于所述第一线打开的阴端（24）中的内部配合表面（23） 以及限定所述第二开口的阳性流体连接器（25），所述第二开口经由其外表面（26）装配到所述阴连接器中并且经由所述阴连接器内部的阳性径向端部（27）终止。 根据本发明，该第二线由柔性微型管形成，该柔性微型管直接通过阳型连接器推动超过阳端，第二线的自由端以密封的方式压靠在阴端上，以便最小化 第一行和公连接器。

公开(公告)号：US20110044899A1

公开(公告)日：2011-02-24

申请号：US12865059

申请日：2009-01-28

申请人： Jean-Michel Chezal ,  Frederic Dolle ,  Jean-Claude Madelmont ,  Aurelie Maisonial ,  Elisabeth Miot-Noirault ,  Nicole Moins ,  Janine Papon ,  Bertrand Kuhnast ,  Bertrand Tavitian ,  Raphael Boisgard

发明人： Jean-Michel Chezal ,  Frederic Dolle ,  Jean-Claude Madelmont ,  Aurelie Maisonial ,  Elisabeth Miot-Noirault ,  Nicole Moins ,  Janine Papon ,  Bertrand Kuhnast ,  Bertrand Tavitian ,  Raphael Boisgard

IPC分类号： A61K51/00 ,  C07D401/12 ,  A61K31/498 ,  C07D241/44 ,  A61K31/4709 ,  C07D213/65 ,  A61K31/44 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/473 ,  C07F7/22 ,  A61K31/555 ,  A61P43/00 ,  A61P35/00

CPC分类号： A61K49/0002 ,  C07D213/65 ,  C07D213/76 ,  C07D215/54 ,  C07D241/44 ,  C07D401/12 ,  C07D487/04

摘要： A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4) alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (β) or (δ): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6) alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a N+R5R6R7X− group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.

摘要翻译： 式（I）化合物：其中R 1表示氢原子，任选标记的卤素，放射性核素或Sn [（C 1 -C 4）烷基] 3基团，Ar表示芳基或杂芳基，R 9表示 氢原子，（C1-C4）烷基或与基团R1-Ar一起形成与Ar基团稠合的环，A表示式（bgr）或（δ）的基团：R 3和R 4独立地表示氢 原子，（C1-C6）烷基，（C1-C6）烯基或式（y）的基团：其中R11表示任选标记的卤素，放射性核素，芳基或杂芳基， 卤素，放射性核素，-NO 2基，-NR 5 R 6基，N + R 5 R 6 R 7 X基或-OSO 2 R 12基，以及它们与药学上可接受的酸的加成盐。