公开(公告)号：US20080317630A1

公开(公告)日：2008-12-25

申请号：US11963171

申请日：2007-12-21

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

IPC分类号： G01N33/49

CPC分类号： G01N1/28 ,  B04B5/0414 ,  B04B2011/046 ,  G01N2035/00495

摘要： The present invention relates in particular to a continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored.An extraction system (10) according to the invention comprises a centrifuge (13) provided with a plurality of microholders (12), at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion.According to the invention, the or each holder thus filled has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

摘要翻译： 本发明特别涉及一种用于物理提取一系列液体微样品的至少一个液相的连续自动提取系统和方法，它们在空间和时间上预先以离散分组的形式被采集并被存储。 根据本发明的提取系统（10）包括设置有多个微型承载器（12）的离心机（13），其中至少一个微型存储器充满相应的微型样品，并且包括一个填充上部分， 部分的截面比上部小。 根据本发明，如此填充的或每个保持器的质量大于该微型样品的质量的十倍，使得可以在给定时刻通过离心提取仅含有一个微量样品 在单个微量元素中，或者这些微量元素的一些或全部中包含的几个微样品，随着后者被填充而逐渐变化。

公开(公告)号：US20080319344A1

公开(公告)日：2008-12-25

申请号：US11954994

申请日：2007-12-12

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

IPC分类号： A61B5/00

CPC分类号： A61M39/10

摘要： The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device.A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises:a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; anda male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.According to the invention, this second line is formed from a flexible microtube pushed right through the male connector beyond the male end, the free end of the second line pressing in a sealed manner against the female end so as to minimize the dead volume between the first line and the male connector.

摘要翻译： 本发明涉及流体连接装置以及使用该装置采集流体微样品的连续自动化系统和方法。 根据本发明的装置（20），其旨在经由第一开口连接到第一线（21）并且包括第二线（28）经过的第二开口，包括：阴性流体连接器（22） ），其限定所述第一开口并且具有终止于所述第一线打开的阴端（24）中的内部配合表面（23） 以及限定所述第二开口的阳性流体连接器（25），所述第二开口经由其外表面（26）装配到所述阴连接器中并且经由所述阴连接器内部的阳性径向端部（27）终止。 根据本发明，该第二线由柔性微型管形成，该柔性微型管直接通过阳型连接器推动超过阳端，第二线的自由端以密封的方式压靠阴性端，从而最小化 第一行和公连接器。

公开(公告)号：US07821248B2

公开(公告)日：2010-10-26

申请号：US11963156

申请日：2007-12-21

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

IPC分类号： G01N15/00 ,  G01N33/48

CPC分类号： A61B6/508 ,  A61B5/150022 ,  A61B5/150229 ,  A61B5/15087 ,  A61B5/155 ,  A61B6/4258 ,  A61B6/481 ,  A61B2503/40

摘要： The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid.A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.

摘要翻译： 本发明涉及一种用于对由流体发射的基本粒子进行计数的装置和方法，该装置包括用于传送流体的管线，并且在管线外部，检测装置（6a）用于检测由壁的壁衰减的颗粒 线和/或这种流体。 根据本发明的计数装置包括至少一个长圆形横截面的计数部分（4a），其连接在具有较大流动部分的线的两个相邻部分上，并具有[内部高度（h）/内部宽度（l） ]比率为20％以下，其中内部高度和内部宽度分别表示该部分的最小和最大的横向尺寸，它们沿两个大致垂直的方向测量，所述检测装置横向于该部分横向延伸，面向其整个 内部宽度和其两侧。

公开(公告)号：US08092445B2

公开(公告)日：2012-01-10

申请号：US11954994

申请日：2007-12-12

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot ,  Raphael Boisgard

IPC分类号： A61M25/16

CPC分类号： A61M39/10

摘要： The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device.A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector. According to the invention, this second line is formed from a flexible microtube pushed right through the male connector beyond the male end, the free end of the second line pressing in a sealed manner against the female end so as to minimize the dead volume between the first line and the male connector.

摘要翻译： 本发明涉及流体连接装置以及使用该装置采集流体微样品的连续自动化系统和方法。 根据本发明的装置（20），其旨在经由第一开口连接到第一线（21）并且包括第二线（28）经过的第二开口，包括：阴性流体连接器（22） ），其限定所述第一开口并且具有终止于所述第一线打开的阴端（24）中的内部配合表面（23） 以及限定所述第二开口的阳性流体连接器（25），所述第二开口经由其外表面（26）装配到所述阴连接器中并且经由所述阴连接器内部的阳性径向端部（27）终止。 根据本发明，该第二线由柔性微型管形成，该柔性微型管直接通过阳型连接器推动超过阳端，第二线的自由端以密封的方式压靠在阴端上，以便最小化 第一行和公连接器。

公开(公告)号：US20080315860A1

公开(公告)日：2008-12-25

申请号：US11963156

申请日：2007-12-21

申请人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

发明人： Jean-Marc Reymond ,  Sophie Kerhoas-Cavata ,  Philippe Mangeot

IPC分类号： G01N15/00

CPC分类号： A61B6/508 ,  A61B5/150022 ,  A61B5/150229 ,  A61B5/15087 ,  A61B5/155 ,  A61B6/4258 ,  A61B6/481 ,  A61B2503/40

摘要： The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid.A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.

摘要翻译： 本发明涉及一种用于对由流体发射的基本粒子进行计数的装置和方法，该装置包括用于传送流体的管线，并且在管线外部，检测装置（6a）用于检测由壁的壁衰减的颗粒 线和/或这种流体。 根据本发明的计数装置包括至少一个长圆形横截面的计数部分（4a），其连接在具有较大流动部分的线的两个相邻部分上，并具有[内部高度（h）/内部宽度（l） ]比率为20％以下，其中内部高度和内部宽度分别表示该部分的最小和最大的横向尺寸，它们沿两个大致垂直的方向测量，所述检测装置横向于该部分横向延伸，面向其整个 内部宽度和其两侧。