公开(公告)号：US20110196002A1

公开(公告)日：2011-08-11

申请号：US13034192

申请日：2011-02-24

申请人： Ashok Kumar GANGOPADHYAY ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

发明人： Ashok Kumar GANGOPADHYAY ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

IPC分类号： A61K31/4245 ,  C07D413/02 ,  A61K31/428 ,  C07D275/02 ,  A61K31/42 ,  C07D271/06 ,  A61P3/00 ,  A61P9/00 ,  A61P19/00 ,  A61P17/00 ,  A61P1/00

CPC分类号： C07D417/12 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D271/06 ,  C07D277/56 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.

摘要翻译： 本发明涉及异恶唑，噻唑和氧化噻唑衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，特别涉及这些化合物在预防和治疗由二酰基甘油酰基转移酶介导的疾病或病症（DGAT ），特别是DGAT1。

公开(公告)号：US20120214854A1

公开(公告)日：2012-08-23

申请号：US13505917

申请日：2010-11-01

申请人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

发明人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

IPC分类号： A61K31/426 ,  C07D277/02 ,  C07D263/02 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00 ,  A61P19/02 ,  A61P19/10 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P21/00 ,  A61P17/10 ,  A61P37/02 ,  A61P17/06 ,  A61P1/00 ,  A61K31/421

CPC分类号： C07D263/34 ,  C07D277/56 ,  C07D277/82 ,  C07D417/12

摘要： Heteroaryl compounds, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or disorders mediated by Diacylglycerol acyltransferase (DGAT) enzyme, particularly DGAT-1 is described.

摘要翻译： 描述了杂芳基化合物，其制备方法，含有它们的药物组合物及其在治疗由二酰基甘油酰基转移酶（DGAT）酶，特别是DGAT-1介导的疾病或病症中的用途。

公开(公告)号：US20130158075A1

公开(公告)日：2013-06-20

申请号：US13820240

申请日：2011-08-31

申请人： Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Shivaji Sadashiv Kandre ,  Amol Gupte

发明人： Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Shivaji Sadashiv Kandre ,  Amol Gupte

IPC分类号： C07D417/04 ,  C07D285/12 ,  C07D263/32 ,  C07D231/12 ,  C07D271/107 ,  C07D277/587

CPC分类号： C07D417/04 ,  C07D207/32 ,  C07D231/12 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D271/107 ,  C07D277/28 ,  C07D277/30 ,  C07D277/56 ,  C07D277/587 ,  C07D285/12 ,  C07D417/06 ,  C07D417/08 ,  C07D417/10 ,  C07D417/12

摘要： The present invention relates to heterocyclic compounds of formula 1, in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, carboxylic acid isosteres and N-oxides. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

摘要翻译： 本发明涉及所有其立体异构和互变异构形式的式1的杂环化合物; 及其药学上可接受的盐，溶剂合物，多晶型物，前药，羧酸等体积和N-氧化物。 本发明还涉及制备杂环化合物的方法和含有它们的药物组合物。 所述化合物及其药物组合物可用于预防和治疗由二酰基甘油酰基转移酶（DGAT）介导的疾病或病症，特别是DGAT1。 本发明还提供了通过向有需要的哺乳动物施用治疗有效量的所述化合物或其药物组合物来治疗这些疾病或病症的方法。

公开(公告)号：US08835428B2

公开(公告)日：2014-09-16

申请号：US13034192

申请日：2011-02-24

申请人： Ashok Kumar Gangopadhyay ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

发明人： Ashok Kumar Gangopadhyay ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

IPC分类号： C07D261/14 ,  C07D417/12 ,  C07D417/14 ,  C07D277/56 ,  A61K31/422 ,  A61K31/427 ,  C07D271/06 ,  C07D413/12 ,  C07D413/14 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/426 ,  C07D261/18 ,  A61K31/428 ,  C07D261/08 ,  A61K31/4439

CPC分类号： C07D417/12 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D271/06 ,  C07D277/56 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.

摘要翻译： 本发明涉及异恶唑，噻唑和氧化噻唑衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，特别涉及这些化合物在预防和治疗由二酰基甘油酰基转移酶介导的疾病或病症（DGAT ），特别是DGAT1。

公开(公告)号：US08748426B2

公开(公告)日：2014-06-10

申请号：US13519910

申请日：2010-12-30

申请人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma

发明人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma

IPC分类号： A61K31/4035 ,  C07D257/12 ,  C07D251/12 ,  C07D403/04 ,  C07D401/04

CPC分类号： C07D209/46 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to heterocyclic compounds in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of the compounds or their pharmaceutical compositions, to a mammal in need thereof.

摘要翻译： 本发明涉及所有其立体异构和互变异构形式的杂环化合物; 及其药学上可接受的盐，药学上可接受的溶剂化物和药学上可接受的多晶型物。 本发明还涉及制备杂环化合物的方法和含有它们的药物组合物。 化合物及其药物组合物可用于预防和治疗由二酰基甘油酰基转移酶（DGAT）介导的疾病或病症，特别是DGAT1。 本发明还提供了通过向有需要的哺乳动物施用治疗有效量的化合物或其药物组合物来治疗这些疾病或病症的方法。

公开(公告)号：US08722901B2

公开(公告)日：2014-05-13

申请号：US13505917

申请日：2010-11-01

申请人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

发明人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

IPC分类号： A61K31/426 ,  A61K31/421 ,  C07D277/30 ,  C07D263/32

CPC分类号： C07D263/34 ,  C07D277/56 ,  C07D277/82 ,  C07D417/12

摘要： Heteroaryl compounds, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or disorders mediated by Diacylglycerol acyltransferase (DGAT) enzyme, particularly DGAT-1 is described.

摘要翻译： 描述了杂芳基化合物，其制备方法，含有它们的药物组合物及其在治疗由二酰基甘油酰基转移酶（DGAT）酶，特别是DGAT-1介导的疾病或病症中的用途。

公开(公告)号：US20120289505A1

公开(公告)日：2012-11-15

申请号：US13519910

申请日：2010-12-30

申请人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma

发明人： Ravindra Dnyandev Jadhav ,  Rajiv Sharma

IPC分类号： A61K31/4035 ,  C07D405/12 ,  C07D401/12 ,  A61K31/455 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/496 ,  A61K31/4439 ,  C07D403/12 ,  A61K31/501 ,  A61K31/497 ,  C07D413/12 ,  A61K31/422 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4196 ,  C07D417/14 ,  A61K31/4709 ,  A61K31/506 ,  C07D209/48 ,  A61P3/04 ,  A61P3/10 ,  A61P25/00 ,  A61P27/02 ,  A61P3/06 ,  A61P1/18 ,  A61P3/00 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P17/10 ,  A61P15/08 ,  A61P31/14 ,  A61P13/12 ,  C07D209/44

CPC分类号： C07D209/46 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to heterocyclic compounds in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

摘要翻译： 本发明涉及所有其立体异构和互变异构形式的杂环化合物; 及其药学上可接受的盐，药学上可接受的溶剂化物和药学上可接受的多晶型物。 本发明还涉及制备杂环化合物的方法和含有它们的药物组合物。 所述化合物及其药物组合物可用于预防和治疗由二酰基甘油酰基转移酶（DGAT）介导的疾病或病症，特别是DGAT1。 本发明还提供了通过向有需要的哺乳动物施用治疗有效量的所述化合物或其药物组合物来治疗这些疾病或病症的方法。