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    Lipid bilayers on nanotextured solid surfaces
    2.
    发明申请
    Lipid bilayers on nanotextured solid surfaces 审中-公开
    纳米纹理固体表面上的脂质双层

    公开(公告)号：US20080160313A1

    公开(公告)日：2008-07-03

    申请号：US11796038

    申请日：2007-04-26

    Applicant: Gabriel Lopez ,  Reema Zeineldin ,  Darryl Sasaki ,  Julie Last

    Inventor： Gabriel Lopez ,  Reema Zeineldin ,  Darryl Sasaki ,  Julie Last

    IPC: B32B9/00 ,  B05D1/18

    CPC classification number: B05D1/185 ,  B05D1/204 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/31

    Abstract: The present disclosure provides various novel suspended planar lipid bilayer assemblies made from bicellar mixtures containing long and short chain phospholipids and methods of making the same. Such bilayer assemblies may additionally incorporate biomolecules such as proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such lipid bilayer assemblies including proteomics, membrane study, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.

    Abstract translation: 本公开提供由包含长链和短链磷脂的双组分混合物制备的各种新颖的悬浮平面脂质双层组件及其制备方法。 这样的双层组件可另外掺入生物分子，例如蛋白质，多肽，生物复合物，跨膜蛋白和其它膜相关化合物。 本公开进一步提供了用于包括蛋白质组学，膜研究，用于医学诊断和环境监测的生物传感，化学和生物战剂螯合，致动器开发和生物燃料电池开发的这种脂质双层组件的用途。

    Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
    3.
    发明授权
    Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers 有权
    腹膜内施用的纳米载体，其基于癌症的炎症环境释放其治疗负荷

    公开(公告)号：US09532949B2

    公开(公告)日：2017-01-03

    申请号：US14233527

    申请日：2012-07-18

    Applicant: Reema Zeineldin

    Inventor： Reema Zeineldin

    IPC: A61K9/51 ,  A61K9/127 ,  A61K31/704 ,  A61K9/00

    CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5153 ,  A61K31/704 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/911

    Abstract: In one embodiment, the invention provides a new design of nanocarrier compositions that release their therapeutic load specifically at intraperitoneal cancers' site. These nanocarriers are administered intraperitoneally and comprise a plurality of porous nanoparticulates that (a) are loaded with one or more pharmaceutically-active agents alone or in combination with imaging agents thus providing a theranostic value and (b) that are encapsulated by and that support a lipid bilayer which is disrupted upon contact with a reactive oxygen species generated within the environment of the cancer. In other embodiments, the invention provides methods of treatment and pharmaceutical compositions comprising nanocarriers as described herein.

    Abstract translation: 在一个实施方案中，本发明提供纳米载体组合物的新设计，其特别在腹膜内癌症部位释放其治疗负荷。 这些纳米载体被腹膜内施用并且包含多个多孔纳米颗粒，其（a）单独或与成像剂组合加载一种或多种药物活性剂，从而提供神经元值，并且（b）被包囊并支持 脂质双层在与癌症环境中产生的活性氧物质接触时被破坏。 在其它实施方案中，本发明提供了治疗方法和包含如本文所述的纳米载体的药物组合物。

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