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    MAGNETICALLY CONTROLLED VALVE FOR FLOW MANIPULATION IN POLYMER MICROFLUIDIC DEVICES
    3.
    发明申请
    MAGNETICALLY CONTROLLED VALVE FOR FLOW MANIPULATION IN POLYMER MICROFLUIDIC DEVICES 审中-公开
    聚合物微流体装置中用于流动控制的磁控制阀

    公开(公告)号：US20080163946A1

    公开(公告)日：2008-07-10

    申请号：US11966958

    申请日：2007-12-28

    申请人： Frank A. Gomez ,  Attila Gaspar ,  Menake E. Piyasena

    发明人： Frank A. Gomez ,  Attila Gaspar ,  Menake E. Piyasena

    IPC分类号： F16K15/14 ,  F16K31/06

    CPC分类号： F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0046 ,  F16K2099/0078 ,  Y10T137/7879 ,  Y10T137/8593

    摘要： A simple, external in-line valve for use in microfluidic devices constructed of elastomer such as polydimethylsiloxane (PDMS) is described. The actuation of the valve is based on the principle that flexible polymer walls of a liquid channel can be pressed together by the aid of a permanent magnet and a small metal bar. In the presence of a small NdFeB magnet lying below the channel of interest, the metal bar is pulled downward simultaneously pushing the thin layer of PDMS down thereby closing the channel stopping any flow of fluid. The operation of the valve is dependent on the thickness of the PDMS layer, the height of the channel, the gap between the chip and the magnet and the strength of the magnet. The microfluidic channels are completely closed to fluid flows commonly used in microfluidic applications. The valve allows for fabrication of a “thin chip” that allows for detection of chromophoric species within the microchannel via an external fiber optics detection system. C18-Modified reverse phase silica particles are packed into the microchannel using a temporary taper created by the magnetic valve and separations using both pressure and electrochromatographic driven methods is detailed.

    摘要翻译： 描述了用于由诸如聚二甲基硅氧烷（PDMS）的弹性体构成的微流体装置的简单的外部在线阀。 阀的致动基于以下原理：液体通道的柔性聚合物壁可以借助于永磁体和小金属棒被压在一起。 在存在位于感兴趣通道下方的小型钕铁硼磁体的同时，向下拉金属棒同时将PDMS的薄层向下拉，从而封闭通道，阻止任何流体流动。 阀的操作取决于PDMS层的厚度，通道的高度，芯片和磁体之间的间隙以及磁体的强度。 微流体通道完全封闭在微流体应用中通常使用的流体流动。 该阀允许制造“薄芯片”，其允许经由外部光纤检测系统检测微通道内的发色物质。 C18-改性反相二氧化硅颗粒使用由磁阀产生的临时锥形装入微通道，并且使用压力和电色谱驱动方法进行分离。

    MAGNETICALLY CONTROLLED VALVE FOR FLOW MANIPULATION IN POLYMER MICROFLUIDIC DEVICES
    4.
    发明申请
    MAGNETICALLY CONTROLLED VALVE FOR FLOW MANIPULATION IN POLYMER MICROFLUIDIC DEVICES 审中-公开
    聚合物微流体装置中用于流动控制的磁控制阀

    公开(公告)号：US20120118410A1

    公开(公告)日：2012-05-17

    申请号：US13297250

    申请日：2011-11-15

    申请人： Frank A. GOMEZ ,  Attila Gaspar ,  Menake E. Piyasena

    发明人： Frank A. GOMEZ ,  Attila Gaspar ,  Menake E. Piyasena

    IPC分类号： F15D1/00

    CPC分类号： F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0046 ,  F16K2099/0078 ,  Y10T137/7879 ,  Y10T137/8593

    摘要： An external in-line valve for use in microfluidic devices constructed of elastomer such as polydimethylsiloxane (PDMS) is described. The valve is actuated by a permanent magnet and a metal bar that press together the polymer walls of a channel. The metal bar is pulled downward by a small NdFeB magnet below the channel, simultaneously pushing the thin layer of PDMS down, closing the channel, and stopping flow of fluid. Operation of the valve is dependent on thickness of the PDMS layer, height of the channel, the gap between chip and magnet, and magnet strength. The valve allows for fabrication of a “thin chip” that allows for detection of chromophoric species within the microchannel via an external fiber optics detection system. C18-Modified reverse phase silica particles are packed into the microchannel using a temporary taper created by the magnetic valve. Separations using both pressure and electrochromatographic driven methods are detailed.

    摘要翻译： 描述了用于由诸如聚二甲基硅氧烷（PDMS）的弹性体构成的微流体装置的外部在线阀。 阀由永久磁铁和将通道的聚合物壁压在一起的金属棒致动。 金属棒由通道下方的小型钕铁硼磁体向下拉，同时将PDMS的薄层向下推动，关闭通道并阻止流体流动。 阀的操作取决于PDMS层的厚度，通道的高度，芯片和磁体之间的间隙以及磁体强度。 该阀允许制造“薄芯片”，其允许经由外部光纤检测系统检测微通道内的发色物质。 使用由磁阀产生的临时锥形将C18-改性的反相二氧化硅颗粒包装到微通道中。 详细介绍了使用压力和电色谱驱动方法的分离。