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    Biological control of nematodes
    1.
    发明申请
    Biological control of nematodes 有权
    线虫的生物防治

    公开(公告)号：US20040170609A1

    公开(公告)日：2004-09-02

    申请号：US10792434

    申请日：2004-03-03

    申请人： Regents of the University of Minnesota, a Minnesota corporation

    发明人： Senyu Chen

    IPC分类号： A01N063/04 ,  A01N063/00

    CPC分类号： A01N63/04 ,  C12R1/645

    摘要： The present invention provides a novel isolated and purified fungus Hirsutella minnesotensis. The present invention also provides a pesticidal composition of an effective amount of an isolated and purified fungal strain of Hirsutella rhossiliensis or Hirsutella minnesotensis that is capable of controlling nematode infestation and a carrier. Further, the present invention provides methods of controlling nematode infestation.

    摘要翻译： 本发明提供了一种新颖的分离和纯化的真菌Hirsutella minnesotensis。 本发明还提供了有效量的能够控制线虫侵染和携带者的分离和纯化的Hirsutella rhossiliensis或Hirsutella minnesotensis的真菌菌株的杀虫组合物。 此外，本发明提供了控制线虫侵染的方法。

    Transgenic non-human mammals with progressive neurologic disease
    3.
    发明申请
    Transgenic non-human mammals with progressive neurologic disease 审中-公开
    具有进行性神经系统疾病的转基因非人哺乳动物

    公开(公告)号：US20030229907A1

    公开(公告)日：2003-12-11

    申请号：US10271314

    申请日：2002-10-15

    申请人： John Hopkins University, a Maryland corporation ,  Regents of the University of Minnesota, a Minnesota corporation

    发明人： Karen Hsiao ,  David R. Borchelt ,  Sangram S. Sisodia

    IPC分类号： A01K067/027

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0318 ,  A01K2267/0343 ,  A01K2267/0356 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/4711 ,  C12N2830/008

    摘要： Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage. In mice, an age-related CNS disorder characterized by agitation, neophobia, seizures, inactivity, diminished cerebral glucose utilization, cortico-limbic gliosis, and death, develops. An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins (APP) produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression. In transgenic mice the disorder develops in direct relationship to brain levels of transgenic APP, but mutant APP confers the phenotype at lower levels of expression than wild-type APP. The disorder occurs in the absence of extracellular amyloid deposition, indicating that some pathogenic activities of APP are dissociated from amyloid formation.

    摘要翻译： 提供了一种转基因非人类真核动物，其生殖细胞和体细胞在胚胎期含有引入动物或动物祖先的淀粉样蛋白前体蛋白质序列。 在小鼠中，发展为以激动，恐惧症，癫痫发作，不活动，脑葡萄糖利用减少，皮层边缘胶质增生和死亡为特征的年龄相关的中枢神经系统疾病。 这种疾病的加速发生在使用赋予与位置无关的拷贝数依赖性表达的仓鼠朊蛋白基因衍生的粘粒载体产生的表达人和小鼠阿尔茨海默氏淀粉样蛋白前体蛋白（APP）的转基因小鼠中。 在转基因小鼠中，病症与转基因APP的脑水平直接相关，但是突变体APP赋予表型低于野生型APP的表型。 该疾病发生在没有细胞外淀粉样蛋白沉积的情况下，表明APP的一些致病活性与淀粉样蛋白形成分离。