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1.发明授权Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect 失效双功能尿激酶变体具有改善的纤维蛋白溶解特征和凝血酶抑制作用
公开(公告)号：US5747291A
公开(公告)日：1998-05-05
申请号：US720012
申请日：1996-09-27
申请人： Gerd J. Steffens , Stephan Wnendt , Johannes Schneider , Regina Heinzel-Wieland , Derek John Saunders
发明人： Gerd J. Steffens , Stephan Wnendt , Johannes Schneider , Regina Heinzel-Wieland , Derek John Saunders
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/49 , A61K38/55 , A61P7/02 , C07K14/81 , C07K19/00 , C12N9/72 , C12N15/58 , C12N15/62 , C12R1/19 , A61K38/48 , C12N15/70
CPC分类号： C12N9/6462 , C12Y304/21073 , A61K38/00
摘要： Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.
摘要翻译： 描述了具有改善的纤维蛋白溶解性质和凝血酶抑制活性的双功能尿激酶变体，用于制备这些多肽的质粒，以及含有双功能尿激酶变体作为活性成分的溶栓剂。
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2.发明授权
公开(公告)号：US6133011A
公开(公告)日：2000-10-17
申请号：US967024
申请日：1997-11-10
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/475 , C07K14/81 , C07K14/815 , C07K19/00 , C12N9/64 , C12N9/72 , C12N15/12 , C12N15/58 , C12P21/02 , C12R1/19 , A61K38/36 , C12N15/62
CPC分类号： C12N9/6456 , C07K14/815 , A61K38/00 , C07K2319/00
摘要： Chimeric proteins with fibrinolytic and thrombin-inhibiting properties having a plasminogen-activating amino acid sequence which is linked at its C-terminal end to a thrombin-inhibiting amino acid sequence.
摘要翻译： 具有纤维蛋白溶解和凝血酶抑制性质的嵌合蛋白质具有纤溶酶原激活氨基酸序列，其在C末端与凝血酶抑制性氨基酸序列连接。
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公开(公告)号：US5976841A
公开(公告)日：1999-11-02
申请号：US560098
申请日：1995-11-17
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/475 , C07K14/815 , C07K19/00 , C12N9/64 , C12N9/72 , C12N15/58 , C12P21/02 , C12R1/19 , C12N15/62 , A61K37/00
CPC分类号： C12N9/6456 , C07K14/815 , A61K38/00 , C07K2319/00
摘要： Proteins having fibrinolytic and coagulation-inhibiting properties which are linked at the N- and/or C-terminal end of the plasminogen-activating amino acid sequence to a thrombin- or factor Xa-inhibiting amino acid sequence. The proteins, which are produced by genetic engineering, are useful as thrombolytic agents.
摘要翻译： 在纤溶酶原激活氨基酸序列的N-末端和/或C末端与凝血酶或因子Xa抑制性氨基酸序列连接的具有纤维蛋白溶解和凝固抑制性质的蛋白质。 通过遗传工程产生的蛋白质可用作溶栓剂。
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4.发明授权Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect 失效双功能尿激酶变体具有改善的纤维蛋白溶解特征和凝血酶抑制作用
公开(公告)号：US5681721A
公开(公告)日：1997-10-28
申请号：US093741
申请日：1993-07-20
申请人： Gerd J. Steffens , Stephan Wnendt , Johannes Schneider , Regina Heinzel-Wieland , Derek John Saunders
发明人： Gerd J. Steffens , Stephan Wnendt , Johannes Schneider , Regina Heinzel-Wieland , Derek John Saunders
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/49 , A61K38/55 , A61P7/02 , C07K14/81 , C07K19/00 , C12N9/72 , C12N15/58 , C12N15/62 , C12R1/19 , A61K38/36
CPC分类号： C12N9/6462 , C12Y304/21073 , A61K38/00
摘要： Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.
摘要翻译： 描述了具有改善的纤维蛋白溶解性质和凝血酶抑制活性的双功能尿激酶变体，用于制备这些多肽的质粒，以及含有双功能尿激酶变体作为活性成分的溶栓剂。
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