公开(公告)号：US20060187410A1

公开(公告)日：2006-08-24

申请号：US10549590

申请日：2004-03-25

申请人： Takao Sato ,  Rei Uchida ,  Kenji Uno

发明人： Takao Sato ,  Rei Uchida ,  Kenji Uno

IPC分类号： G02C7/04

CPC分类号： G02B1/041 ,  A61F2/16 ,  A61F9/0017 ,  A61F2250/0067 ,  C08F230/02 ,  C08L43/02 ,  G02B1/043 ,  C08L33/00 ,  C08L2666/02

摘要： An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained drug releasability can regulate the amount of the drug included therein, depending on the efficacy of the drug used, and storing solution for a practical ophthalmic lens. The present invention relates to a drug delivery ophthalmic lens comprising a cationic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer having a hydroxyl group in its molecule, at least one member selected from specific phosphate group-containing methacrylates a monomer having a nitrogen atom in its side chain, and a monomer copolymerizable with these components, and also relates to a drug delivery ophthalmic lens comprising an anionic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer, cationic and anionic monomers, and a monomer copolymerizable with these components, wherein the copolymer contains the anionic monomer in a ratio of 30 to 90 mol % to the cationic monomer, and also relates to storing solution for a practical ophthalmic lens.

摘要翻译： 本发明的目的是提供一种实用的眼用透镜，其具有有效地保持和持续释放药物的效果，并且在药物释放之前和之后具有形式稳定性，其中具有持续药物释放性的离子聚合物凝胶可调节量 包括在内的药物，取决于所用药物的功效，以及用于实际眼科镜片的储存溶液。 本发明涉及一种药物输送眼用透镜，其在由分子中具有羟基的亲水性单体组成的共聚物的内部含有含阳离子基团的药物，至少一种选自特定的含磷酸酯基的甲基丙烯酸酯，单体 在其侧链中具有氮原子，以及可与这些组分共聚的单体，还涉及在由亲水性单体，阳离子和阴离子单体构成的共聚物的内部含有含阴离子基团的药物的药物输送眼用透镜， 和可与这些组分共聚的单体，其中共聚物含有与阳离子单体的比率为30至90mol％的阴离子单体，并且还涉及用于实际眼用透镜的溶液。

公开(公告)号：US07811601B2

公开(公告)日：2010-10-12

申请号：US10549590

申请日：2004-03-25

申请人： Takao Sato ,  Rei Uchida ,  Kenji Uno

发明人： Takao Sato ,  Rei Uchida ,  Kenji Uno

IPC分类号： A61K9/00 ,  A61K9/14 ,  G02B1/04 ,  C08F30/02 ,  C08F130/02 ,  C08F230/02 ,  C08F12/28 ,  C08F20/52 ,  C08F20/70 ,  C08F22/40 ,  C08F120/52 ,  C08F120/70 ,  C08F122/40 ,  C08F220/52 ,  C08F222/40

CPC分类号： G02B1/041 ,  A61F2/16 ,  A61F9/0017 ,  A61F2250/0067 ,  C08F230/02 ,  C08L43/02 ,  G02B1/043 ,  C08L33/00 ,  C08L2666/02

摘要： An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained drug releasability can regulate the amount of the drug included therein, depending on the efficacy of the drug used, and storing solution for a practical ophthalmic lens.The present invention relates to a drug delivery ophthalmic lens comprising a cationic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer having a hydroxyl group in its molecule, at least one member selected from specific phosphate group-containing methacrylates a monomer having a nitrogen atom in its side chain, and a monomer copolymerizable with these components, and also relates to a drug delivery ophthalmic lens comprising an anionic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer, cationic and anionic monomers, and a monomer copolymerizable with these components, wherein the copolymer contains the anionic monomer in a ratio of 30 to 90 mol % to the cationic monomer, and also relates to storing solution for a practical ophthalmic lens.

摘要翻译： 本发明的目的是提供一种实用的眼用透镜，其具有有效地保持和持续释放药物的效果，并且在药物释放之前和之后具有形式稳定性，其中具有持续药物释放性的离子聚合物凝胶可调节量 包括在内的药物，取决于所用药物的功效，以及用于实际眼科镜片的储存溶液。 本发明涉及一种药物输送眼用透镜，其在由分子中具有羟基的亲水性单体组成的共聚物的内部含有含阳离子基团的药物，至少一种选自特定的含磷酸酯基的甲基丙烯酸酯，单体 在其侧链中具有氮原子，以及可与这些组分共聚的单体，还涉及在由亲水性单体，阳离子和阴离子单体构成的共聚物的内部含有含阴离子基团的药物的药物输送眼用透镜， 和可与这些组分共聚的单体，其中共聚物含有与阳离子单体的比率为30至90mol％的阴离子单体，并且还涉及用于实际眼用透镜的溶液。