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公开(公告)号：US4873087A
公开(公告)日：1989-10-10
申请号：US355887
申请日：1982-03-08
CPC分类号： A61K9/02 , A61K47/183 , A61K47/42 , Y10S514/946 , Y10S514/947 , Y10S514/966 , Y10S514/967
摘要： A preparation containing an absorption promoter selected from N-acyl amino acid derivatives or N-acyl peptide derivatives represented by the formula: R-CO-A (R is an aliphatic hydrocarbon group, an aromatic hydrocarbon group or an aryl-substituted lower hydrocarbon group which may optionally be substituted, and A is an amino acid residue or a peptide residue), preferably in the presence of a salt at a concentation exhibiting higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon and rectum, and through the vagina.
摘要翻译： 含有选自N-酰基氨基酸衍生物或由下式表示的N-酰基肽衍生物的吸收促进剂的制剂：R-CO-A（R为脂族烃基，芳族烃基或芳基取代的低级烃基 其可以任选被取代，A是氨基酸残基或肽残基），优选在与等渗氯化钠溶液相比表现出较高渗透压浓度的盐存在下，发现药物促进药物的吸收 通过胃肠器官如结肠和直肠，并通过阴道。
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公开(公告)号：US4609640A
公开(公告)日：1986-09-02
申请号：US342080
申请日：1982-01-25
IPC分类号： A61K47/30 , A61K9/00 , A61K9/02 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , B01F5/24 , C07K7/10 , C07K7/36
CPC分类号： A61K47/42 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/0031 , A61K9/0034 , B01F5/24
摘要： A preparation containing an absorption promoter selected from specific classes of water-soluble macromolecular compounds having chelating activity, preferably in the presence of a salt at a concentration such that the composition exhibits higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon, rectum, or vagina.
摘要翻译： 含有选自具有螯合活性的具体类型的水溶性大分子化合物的吸收促进剂的制剂，优选在盐浓度使组合物表现出比等渗氯化钠溶液更高的渗透压的浓度，并且发现药物 促进药物通过胃肠器官如结肠，直肠或阴道吸收。
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