公开(公告)号：US06645212B2

公开(公告)日：2003-11-11

申请号：US10273166

申请日：2002-10-18

申请人： Jörg Goldhahn ,  Reto Frei ,  Jörn Seebeck

发明人： Jörg Goldhahn ,  Reto Frei ,  Jörn Seebeck

IPC分类号： A61B1758

CPC分类号： A61B17/8625 ,  A61B17/68 ,  A61B17/8052 ,  A61B17/864

摘要： The present invention concerns a fastening element for use in bone, and in particular to a device for fixating implants on or in bone. The device may have a longitudinal axis for anchoring in bone and may comprise a core and at least one wing extending from the core. The wing may have an enlarged peripheral portion adapted to contact bone. A cross-section of the device transverse to the longitudinal axis may have first and second portions, the first portion comprising the core and defining a first cross-sectional area, the second portion comprising the enlarged peripheral portion of the at least one wing and defining a second cross-sectional area, and the second cross-sectional area preferably is greater than the first cross-sectional area. The ratio of the second portion to the first portion preferably being at least about 3:1

摘要翻译： 本发明涉及一种用于骨骼的紧固元件，特别涉及用于固定植入物或骨骼中的植入物的装置。 该装置可以具有用于锚定在骨中的纵向轴线，并且可以包括芯部和从芯部延伸的至少一个翼片。 翼可以具有适于接触骨的扩大的周边部分。 横向于纵向轴线的装置的横截面可以具有第一和第二部分，第一部分包括芯并且限定第一横截面区域，第二部分包括至少一个翼的扩大的周边部分并且限定 第二横截面积和第二横截面面积优选地大于第一横截面面积。 第二部分与第一部分的比例优选为至少约3:1

公开(公告)号：US08753379B1

公开(公告)日：2014-06-17

申请号：US10240526

申请日：2000-03-07

申请人： Reto Frei ,  Markus Hehli ,  Georg Duda

发明人： Reto Frei ,  Markus Hehli ,  Georg Duda

IPC分类号： A61B17/80

CPC分类号： A61B17/8047 ,  A61B17/1728 ,  A61B17/1735 ,  A61B17/1739 ,  A61B17/1778 ,  A61B17/1796 ,  A61B17/8052 ,  A61B17/8057 ,  A61B17/8085 ,  A61B17/82 ,  A61B17/8635 ,  A61B2017/00004

摘要： A guide body is designed to receive longitudinal fixation elements such as wires nails, pegs or screws which are to be anchored within bone. The guide body includes a top surface, a bottom surface, and a number of openings connecting the top surface with the bottom surface. The central axes of at least two of the openings are transverse to each other. The guide body permits the insertion of fixation elements at various angles with respect to each other. The guide body may prevent fixation elements which extend into the intramedullary region or the spongiosa from being displaced either in the proximal or in the distal direction.

摘要翻译： 引导体设计成接收要锚定在骨骼内的纵向固定元件，例如电线钉，钉或螺钉。 引导体包括顶表面，底表面和连接顶表面与底表面的多个开口。 至少两个开口的中心轴线彼此横向。 引导体允许相对于彼此以各种角度插入固定元件。 引导体可以防止延伸到髓内区域或海绵体的固定元件在近端或远端方向上移位。

公开(公告)号：US06780185B2

公开(公告)日：2004-08-24

申请号：US10267872

申请日：2002-10-10

申请人： Reto Frei ,  Markus Hehli

发明人： Reto Frei ,  Markus Hehli

IPC分类号： A61B1774

CPC分类号： A61B17/746 ,  A61B17/7266

摘要： The invention relates to an osteosynthetic anchoring member comprising a longitudinal shaft extending along a longitudinal axis having a front shaft portion and a rear shaft portion, the front shaft portion insertable into a bone and comprising anchoring means for fixating the shaft in the bone and the rear shaft portion comprising anti-rotation means for permitting the rear shaft portion to be received in an implantable bone plate or a connecting member and to be secured against rotating about the longitudinal axis. The anchoring means are capable of being extended orthogonally with respect to the longitudinal axis of the shaft, and the rear shaft portion comprises tension means for extending the anchoring means to enable the anchoring member to be fixated within the bone. Also disclosed is a fixation device including such an anchoring member for fixating fractured femoral heads comprising the anchoring member to be fixated within the fractured femoral head, a plate to be screwed to the main part of the femur including a sleeve in which the anchoring member may be received and wherein it is displaceable coaxially to the longitudinal axis, and a compression bone screw to be screwed into the internal screw thread of a spindle.

摘要翻译： 本发明涉及一种骨接合锚固构件，其包括沿着具有前轴部分和后轴部分的纵向轴线延伸的纵向轴，所述前轴部分可插入骨骼中，并且包括用于将轴固定在骨骼中的固定装置和后部 轴部分包括防旋转装置，用于允许后轴部分被容纳在可植入骨板或连接构件中并且被固定以防止围绕纵向轴线旋转。 锚固装置能够相对于轴的纵向轴线正交延伸，并且后轴部分包括用于延伸锚固装置的张紧装置，以使锚固构件能够固定在骨骼内。 还公开了一种固定装置，其包括用于固定骨折股骨头的固定构件，该股骨头包括固定在股骨头骨折头内的锚定构件，待固定在股骨主体部分上的板，该板包括套筒，锚固构件 被接收并且其可以与纵向轴线同轴移位，以及压缩骨螺钉，其被拧入主轴的内螺纹中。

公开(公告)号：US20130136782A1

公开(公告)日：2013-05-30

申请号：US13669368

申请日：2012-11-05

申请人： Helen BLACKWELL ,  Reto Frei ,  Anthony Breitbach ,  David M. Lynn ,  Adam H. Broderick

发明人： Helen BLACKWELL ,  Reto Frei ,  Anthony Breitbach ,  David M. Lynn ,  Adam H. Broderick

IPC分类号： A01N43/52 ,  A61K31/416 ,  A61K45/00 ,  C07D235/30

CPC分类号： A01N43/52 ,  A61K31/416 ,  A61K31/4184 ,  A61K45/00 ,  C07D235/02 ,  C07D235/30

摘要： Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

摘要翻译： 本文所述的化合物抑制生物膜形成或分散革兰阴性菌的预先形成的生物膜。 生物膜抑制化合物可以被包封或包含在聚合物基质中用于控制释放。 还提供了涂层，膜，多层膜，水凝胶，微球和纳米球以及含有生物膜抑制化合物的药物组合物和消毒组合物。 提供了抑制生物膜形成或分散已形成生物膜的方法。 用于治疗形成生物膜的革兰氏阴性细菌感染的方法，特别是假单胞菌，特别是铜绿假单胞菌的感染的方法。

公开(公告)号：US07862596B2

公开(公告)日：2011-01-04

申请号：US10314406

申请日：2002-12-09

申请人： Markus Hehli ,  Reto Frei ,  Georg Duda

发明人： Markus Hehli ,  Reto Frei ,  Georg Duda

IPC分类号： A61B17/80

CPC分类号： A61B17/72 ,  A61B17/1728 ,  A61B17/1778 ,  A61B17/80 ,  A61B17/8061 ,  A61B17/8635 ,  A61B17/8645 ,  A61B2017/00004

摘要： The invention relates to an osteosynthesis implant (1) that preferably consists of a bioresorbable plastic material. The inventive implant receives the longitudinal fixation elements (10) to be anchored in the bone, especially in the form of wires, nails, pins or screws. The openings destined to receive the fixation elements (10) do not completely extend through the implant (1) like in conventional bone plates or intramedullary nails but are degenerated to indents (2) in the surface of the implant (1) so that they may serve as a guide for the fixation elements (10) to be guided through the implant (1). The inventive implant (1) allows insertion of the fixation elements (10) in the bone diverging angles and crossing one another, so that the fixation elements (10) extending intramedullarly or in the spongiosa are primarily prevented from migrating in a proximal or distal direction.

摘要翻译： 本发明涉及一种优选由生物可再吸收的塑料材料组成的骨接合植入物（1）。 本发明的植入物容纳要锚固在骨骼中的纵向固定元件（10），特别是以电线，钉子，销钉或螺钉的形式。 注入接收固定元件（10）的开口不像传统骨板或髓内钉那样完全延伸通过植入物（1），而是在植入物（1）的表面中退化为凹陷（2），使得它们可以 用作通过植入物（1）引导的固定元件（10）的引导件。 本发明的植入物（1）允许固定元件（10）插入骨发散角度并且彼此交叉，使得主要或在海绵状体中延伸的固定元件（10）主要被防止在近端或远端方向上移动 。

公开(公告)号：US20110071574A1

公开(公告)日：2011-03-24

申请号：US12952926

申请日：2010-11-23

申请人： Markus Hehli ,  Reto Frei ,  Georg Duda

发明人： Markus Hehli ,  Reto Frei ,  Georg Duda

IPC分类号： A61B17/80

CPC分类号： A61B17/72 ,  A61B17/1728 ,  A61B17/1778 ,  A61B17/80 ,  A61B17/8061 ,  A61B17/8635 ,  A61B17/8645 ,  A61B2017/00004

摘要： The invention relates to an osteosynthesis implant (1) that preferably consists of a bioresorbable plastic material. The inventive implant receives the longitudinal fixation elements (10) to be anchored in the bone, especially in the form of wires, nails, pins or screws. The openings destined to receive the fixation elements (10) do not completely extend through the implant (1) like in conventional bone plates or intramedullary nails but are degenerated to indents (2) in the surface of the implant (1) so that they may serve as a guide for the fixation elements (10) to be guided through the implant (1). The inventive implant (1) allows insertion of the fixation elements (10) in the bone diverging angles and crossing one another, so that the fixation elements (10) extending intramedullarly or in the spongiosa are primarily prevented from migrating in a proximal or distal direction.

摘要翻译： 本发明涉及一种优选由生物可再吸收的塑料材料组成的骨接合植入物（1）。 本发明的植入物容纳要锚固在骨骼中的纵向固定元件（10），特别是以电线，钉子，销钉或螺钉的形式。 注入接收固定元件（10）的开口不像传统骨板或髓内钉那样完全延伸通过植入物（1），而是在植入物（1）的表面中退化为凹陷（2），使得它们可以 用作通过植入物（1）引导的固定元件（10）的引导件。 本发明的植入物（1）允许固定元件（10）插入骨发散角度并且彼此交叉，使得主要或在海绵状体中延伸的固定元件（10）主要被防止在近端或远端方向上移动 。