公开(公告)号：US20180292305A1

公开(公告)日：2018-10-11

申请号：US15764030

申请日：2016-09-27

申请人： Shana KELLEY ,  Edward SARGENT ,  Mahla POUDINEH ,  Reza MOHAMADI ,  Peter ALDRIDGE

发明人： Shana KELLEY ,  Edward SARGENT ,  Mahla POUDINEH ,  Reza MOHAMADI ,  Peter ALDRIDGE

IPC分类号： G01N15/14 ,  G01N33/49 ,  G01N33/574 ,  B01L3/00 ,  B03C1/28 ,  B03C1/033 ,  B03C1/30

CPC分类号： G01N15/1484 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  G01N15/1475 ,  G01N33/491 ,  G01N33/57492 ,  G01N2015/1006 ,  G01N2015/149

摘要： Methods and devices for magnetic profiling of target particles in a flow. There are a plurality of flow rate-reducing structures in a flow chamber. Each flow rate-reducing structure is provided with a localized magnetic attractive force, the magnetic attractive force defining a capture zone in the vicinity of the flow rate-reducing structure. The size of capture zones may be variable for different locations within the device. The magnetic attractive force, in the capture zone, is sufficiently high to overcome the drag force on a given subset of the target particles to promote capture of any particles belonging to the subset of the target particles in the capture zone. Different target particles having different magnetic susceptibility are captured in different capture zones.