摘要:
The characteristic voltage-versus-time curve for a nickel-cadmium battery on a fast charge, e.g., being charged at the C/1 rate, increases to a peak voltage and thereafter decreases. To ensure that the battery is fully charged, the fast charge is discontinued on the decreasing portion of the voltage-versus-time curve. The fast charge may be stopped when a predetermined negative rate of change of the voltage is obtained. Or the fast charge may be cut off when the battery voltage decreases a predetermined amount below the peak, that is, when the difference between the maximum measured battery voltage and the present battery voltage exceeds a setpoint. After the fast charge is discontinued, a trickle charge, e.g., a C/10 charge or less, may be instituted or the charging current may be interrupted altogether, i.e., the battery charging circuit may be opened.
摘要:
The present invention relates to immunogenic peptides derived from human prostate cancer antigen (PSA-derived peptides) and their use as vaccines to treat or prevent prostate cancer. The invention is also related to dendritic cells from a patient having prostate cancer, which dendritic cells have been exposed to one or more PSA-derived peptides, and their use to treat or prevent prostate cancer in the patient. The invention is also directed to T-cells from a patient which cells are specific for PSA-activated peptide(s), and their uses to treat or prevent prostate cancer.
摘要:
The present invention provides a superior method of diagnosing Chronic Pelvic Pain Syndrome in men comprising measuring levels of cytokines in semen or components or fractions of semen. The invention also provides a method of treating a condition associated with elevated levels of a cytokine, such as TNF-&agr;, in semen or a component or fraction thereof, comprising administering a therapeutically effective amount of an ant-cytokine compound or composition, such as an anti-TNF-&agr; compound or composition.
摘要:
The present invention relates to immunogenic peptides derived from human prostate cancer antigen (PSA-derived peptides) and their use as vaccines to treat or prevent prostate cancer. The invention is also related to dendritic cells from a patient having prostate cancer, which dendritic cells have been exposed to one or more PSA-derived peptides, and their use to treat or prevent prostate cancer in the patient. The invention is also directed to T-cells from a patient which cells are specific for PSA-activated peptide(s), and their uses to treat or prevent prostate cancer.
摘要:
A nucleic acid molecule comprising at least one nucleotide sequence encoding SEQ ID NO: 14, 15, 19, 41, or a sequence that is at least about 95% identical thereto; a composition comprising same and a method of administering same to induce an immune response; a polypeptide consisting of SEQ ID NO: 14, 15, 19, 41, or a sequence that is at least about 95% identical thereto; a composition comprising same and a method of administering same to induce an immune response; a composition comprising APC, which have been exposed to the polypeptide, and a method of administering same to treat prostate cancer; a composition comprising T-cells, which are specific for an epitope in a polypeptide consisting of SEQ ID NO: 14, 15, 19, or 41 and a method of administering same to treat prostate cancer; a composition comprising an anti-idiotypic antibody having an internal image of an epitope of a polypeptide consisting of SEQ ID NO: 14, 15, 19, or 41 and a method of administering same to treat prostate cancer; and an immortal B-cell line that produces an anti-idiotypic monoclonal antibody having an internal image of an epitope of a polypeptide consisting of SEQ ID NO: 14, 15, 19, or 41.
摘要翻译:核酸分子,其包含至少一个编码SEQ ID NO:14,15,19,41的核苷酸序列或与其至少约95%同一性的序列; 包含其组合物的组合物和施用其以诱导免疫应答的方法; 由SEQ ID NO:14,15,19,41组成的多肽或与其至少约95%同一性的序列; 包含其组合物的组合物和施用其以诱导免疫应答的方法; 已经暴露于多肽的包含APC的组合物以及其治疗前列腺癌的方法; 包含T细胞的组合物,其对由SEQ ID NO:14,15,19或41组成的多肽中的表位是特异性的,以及其给予治疗前列腺癌的方法; 包含具有由SEQ ID NO:14,15,19或41组成的多肽的表位的内部图像的抗独特型抗体的组合物及其治疗前列腺癌的方法; 以及产生具有由SEQ ID NO:14,15,19或41组成的多肽的表位的内部图像的抗独特型单克隆抗体的不朽B细胞系。