公开(公告)号：US08673323B2

公开(公告)日：2014-03-18

申请号：US13343869

申请日：2012-01-05

申请人： Stavros Thomopoulos ,  Shelly Sakiyama-Elbert ,  Matthew Silva ,  Richard Gelberman ,  Younan Xia ,  Andrea Schwartz ,  Jingwei Xie

发明人： Stavros Thomopoulos ,  Shelly Sakiyama-Elbert ,  Matthew Silva ,  Richard Gelberman ,  Younan Xia ,  Andrea Schwartz ,  Jingwei Xie

IPC分类号： A61F2/02 ,  A61K35/12 ,  A61K38/18 ,  A61F2/28 ,  A61F2/08

CPC分类号： A61L27/54 ,  A61F2002/30766 ,  A61K38/00 ,  A61L27/18 ,  A61L27/26 ,  C07K14/47 ,  C07K14/475 ,  C07K14/75 ,  C12N9/6429 ,  Y10T156/10

摘要： A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

摘要翻译： 生长因子递送支架将基于肝素/纤维蛋白的递送系统（HBDS）与基于用于组织（例如肌腱和韧带）修复的聚合物纳米纤维的骨架组合。 与现有技术的HBDS系统的凝胶状稠度相比，支架具有改善的手术处理性质，并且保留了递送间充质细胞并控制生长因子释放的能力。 支架的一个应用是用于屈肌腱修复的间充质干细胞（MSC）治疗。 支架可以以持续的方式输送生长因子，可以植入用于屈肌腱修复，是生物相容的，并且不是细胞毒性的。 生长因子递送支架也可用于外科手术修复对骨，肌肉，软骨或其他组织的损伤。

公开(公告)号：US20130004541A1

公开(公告)日：2013-01-03

申请号：US13343869

申请日：2012-01-05

申请人： Stavros Thomopoulos ,  Shelly Sakiyama-Elbert ,  Matthew Silva ,  Richard Gelberman ,  Younan Xia ,  Andrea Schwartz ,  Jingwei Xie

发明人： Stavros Thomopoulos ,  Shelly Sakiyama-Elbert ,  Matthew Silva ,  Richard Gelberman ,  Younan Xia ,  Andrea Schwartz ,  Jingwei Xie

IPC分类号： A61F2/02 ,  A61F2/08 ,  A61F2/28 ,  A61K35/12 ,  A61K38/18

CPC分类号： A61L27/54 ,  A61F2002/30766 ,  A61K38/00 ,  A61L27/18 ,  A61L27/26 ,  C07K14/47 ,  C07K14/475 ,  C07K14/75 ,  C12N9/6429 ,  Y10T156/10

摘要： A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.

摘要翻译： 生长因子递送支架将基于肝素/纤维蛋白的递送系统（HBDS）与基于用于组织（例如肌腱和韧带）修复的聚合物纳米纤维的骨架组合。 与现有技术的HBDS系统的凝胶状稠度相比，支架具有改善的手术处理性质，并且保留了递送间充质细胞并控制生长因子释放的能力。 支架的一个应用是用于屈肌腱修复的间充质干细胞（MSC）治疗。 支架可以以持续的方式输送生长因子，可以植入用于屈肌腱修复，是生物相容的，并且不是细胞毒性的。 生长因子递送支架也可用于外科手术修复对骨，肌肉，软骨或其他组织的损伤。